Author(s): Purva Raju Kesarkar, Sarika Ajinath Bhise, Pranita Narayan Khot, Mahesh Babaso Kolap

Email(s): kolapmb@gmail.com

DOI: 10.52711/2321-5836.2025.00036   

Address: Purva Raju Kesarkar1, Sarika Ajinath Bhise1, Pranita Narayan Khot1, Mahesh Babaso Kolap2
1Department of Pharmacology, Womens College of Pharmacy, Peth Vadgaon, Kolhapur, Maharashtra, India, 416112.
2Associate Professor, Department of Pharmacology, Womens College of Pharmacy, Peth Vadgaon, Kolhapur, Maharashtra, India, 416112.
*Corresponding Author

Published In:   Volume - 17,      Issue - 3,     Year - 2025


ABSTRACT:
Headaches, particularly primary headaches like migraines and tension-type headaches are among the most prevalent neurological disorders globally. These conditions, though often overlooked due to their episodic nature and lack of mortality, significantly impact public health by reducing quality of life and increasing healthcare costs. The review explores the etiology, pathophysiology, and therapeutic approaches for primary headaches, emphasizing the mechanisms underlying tension-type headaches and migraines. Furthermore, the paper examines the pharmacological and herbal treatments used for headache relief, highlighting the role of ssynthetic drugs such as NSAIDs and serotonin receptor agonists, alongside traditional remedies like Clitoria ternatea. This plant, rich in anthocyanins and other bioactive compounds, offers anti-inflammatory, antioxidant, and neuroprotective properties, which make it a potential adjunctive treatment for headache management. By integrating both modern and traditional approaches, the review underscores the complexity of headache disorders and the necessity for multifaceted therapeutic strategies.


Cite this article:
Purva Raju Kesarkar, Sarika Ajinath Bhise, Pranita Narayan Khot, Mahesh Babaso Kolap. Evaluating Clitoria ternatea: A Natural Remedy for Headache Management. Research Journal of Pharmacology and Pharmacodynamics.2025;17(3):220-6. doi: 10.52711/2321-5836.2025.00036

Cite(Electronic):
Purva Raju Kesarkar, Sarika Ajinath Bhise, Pranita Narayan Khot, Mahesh Babaso Kolap. Evaluating Clitoria ternatea: A Natural Remedy for Headache Management. Research Journal of Pharmacology and Pharmacodynamics.2025;17(3):220-6. doi: 10.52711/2321-5836.2025.00036   Available on: https://rjppd.org/AbstractView.aspx?PID=2025-17-3-11


REFERENCES:
1.    Goadsby PJ, Schoenen J, Ferrari MD, Silberstein SD, Dodick D. Towards a definition of intractable headache for use in clinical practice and trials. Cephalalgia. 2006 Sep; 26(9): 1168-70.
2.    Rasmussen BK. Epidemiology of headache. Cephalalgia. 2001 Sep; 21(7): 774-7.
3.    Multisona RR, Shirodkar S, Arnold M, Gramza-Michalowska A. Clitoria ternatea flower and its bioactive compounds: Potential use as microencapsulated ingredient for functional foods. Applied Sciences. 2023 Feb 7; 13(4): 2134.
4.    Mukherjee PK, Kumar V, Kumar NS, Heinrich M. The Ayurvedic medicine Clitoria ternatea—From traditional use to scientific assessment. Journal of Ethnopharmacology. 2008 Dec 8; 120(3): 291-301.
5.    Wang Y, Liu T, Xie Y, Li N, Liu Y, Wen J, Zhang M, Feng W, Huang J, Guo Y, Junior TK. Clitoria ternatea blue petal extract protects against obesity, oxidative stress, and inflammation induced by a high-fat, high-fructose diet in C57BL/6 mice. Food Research International. 2022 Dec 1; 162: 112008.
6.    Ahmed F. Headache disorders: differentiating and managing the common subtypes. British journal of pain. 2012 Aug; 6(3): 124-32.
7.    May A. Hints on diagnosing and treating headache. Deutsches Ärzteblatt International. 2018 Apr; 115(17): 299.
8.    Jensen R. Peripheral and central mechanisms in tension-type headache: an update. Cephalalgia. 2003 May; 23(1_suppl): 49-52.
9.    Hernandez J, Molina E, Rodriguez A, Woodford S, Nguyen A, Parker G, Lucke-Wold B. Headache disorders: differentiating primary and secondary etiologies. Journal of Integrative Neuroscience. 2024 Feb 20; 23(2): 43.
10.    Charles A. The evolution of a migraine attack–a review of recent evidence. Headache: The Journal of Head and Face Pain. 2013 Feb; 53(2): 413-9.
11.    Leroux E, Ducros A. Cluster headache. Orphanet Journal of Rare Diseases. 2008 Dec; 3 :1-1.
12.    Gibson KF, Santos AD, Lund N, Jensen R, Stylianou IM. Genetics of cluster headache. Cephalalgia. 2019 Sep; 39(10): 1298-312.
13.    Palmieri A, Valentinis L, Zanchin G. Update on headache and brain tumors. Cephalalgia. 2021 Apr; 41(4): 431-7.
14.    Lin SH, Ho CY. Paranasal sinus pathologies in patients presenting with headache as the primary symptom. Cephalalgia. 2006 Apr; 26(4): 423-7.
15.    Gupta VK. Systemic hypertension, headache, and ocular hemodynamics: a new hypothesis. Medscape General Medicine. 2006; 8(3): 63.
16.    Toom K, Braschinsky M, Obermann M, Katsarava Z. Secondary headache attributed to exposure to or overuse of a substance. Cephalalgia. 2021 Apr; 41(4): 443-52.
17.    Jensen R. Pathophysiological mechanisms of tension-type headache: a review of epidemiological and experimental studies. Cephalalgia. 1999 Jul; 19(6): 602-21.
18.    Wagh, Mahesh and Mane, Dhananjay. (2022). Migraine-the periodic attacks and impact of medications. 
19.    Fumal A, Schoenen J. Tension-type headache: current research and clinical management. The Lancet Neurology. 2008 Jan 1; 7(1): 70-83.
20.    Alstadhaug KB, Ofte HK. Klasehodepine. Tidsskrift for Den norske legeforening. 2015 Aug 25.
21.    Lijon MB, Meghla NS, Jahedi E, Rahman MA, Hossain I. Phytochemistry and pharmacological activities of Clitoria ternatea. International Journal of Natural and Social Sciences. 2017 Jan; 4(1): 1-0.
22.    Oguis GK, Gilding EK, Jackson MA, Craik DJ. Butterfly pea (Clitoria ternatea), a cyclotide-bearing plant with applications in agriculture and medicine. Frontiers in Plant Science. 2019 May 28; 10: 645.
23.    Ali Z, Ganie SH, Narula A, Sharma MP, Srivastava PS. Intra-specific genetic diversity and chemical profiling of different accessions of Clitoria ternatea L. Industrial Crops and Products. 2013 May 1; 43: 768-73.
24.    Chayaratanasin P, Caobi A, Suparpprom C, Saenset S, Pasukamonset P, Suanpairintr N, Barbieri MA, Adisakwattana S. Clitoria ternatea flower petal extract inhibits adipogenesis and lipid accumulation in 3T3-L1 preadipocytes by downregulating adipogenic gene expression. Molecules. 2019 May 17; 24(10): 1894.
25.    M Calderon-Montano J, Burgos-Morón E, Pérez-Guerrero C, López-Lázaro M. A review on the dietary flavonoid kaempferol. Mini Reviews in Medicinal Chemistry. 2011 Apr 1; 11(4): 298-344.
26.    Comalada M, Ballester I, Bailón E, Sierra S, Xaus J, Gálvez J, de Medina FS, Zarzuelo A. Inhibition of pro-inflammatory markers in primary bone marrow-derived mouse macrophages by naturally occurring flavonoids: analysis of the structure–activity relationship. Biochemical Pharmacology. 2006 Oct 16; 72(8): 1010-21.
27.    Boots AW, Haenen GR, Bast A. Health effects of quercetin: from antioxidant to nutraceutical. European Journal of Pharmacology. 2008 May 13; 585(2-3): 325-37.
28.    Farhan M, Zafar A, Chibber S, Khan HY, Arif H, Hadi SM. Mobilization of copper ions in human peripheral lymphocytes by catechins leading to oxidative DNA breakage: A structure activity study. Archives of Biochemistry and Biophysics. 2015 Aug 15; 580: 31-40.
29.    Loke WM, Hodgson JM, Proudfoot JM, McKinley AJ, Puddey IB, Croft KD. Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men. The American Journal of Clinical Nutrition. 2008 Oct 1; 88(4): 1018-25.
30.    Wyss D, Bonneau O, Trifilieff A. Mast cell involvement in the adenosine mediated airway hyper-reactivity in a murine model of ovalbumin-induced lung inflammation. British Journal of Pharmacology. 2005 Aug 8; 145(7): 845.
31.    Lakshan SA, Jayanath NY, Abeysekera WP, Abeysekera WK. A commercial potential blue pea (Clitoria ternatea L.) flower extract incorporated beverage having functional properties. Evidence‐Based Complementary and Alternative Medicine. 2019; 2019(1): 2916914.
32.    Swathi KP, Jayaram S, Sugumar D, Rymbai E. Evaluation of anti-inflammatory and anti-arthritic property of ethanolic extract of Clitoria ternatea. Chinese Herbal Medicines. 2021 Apr 1; 13(2): 243-9.
33.    Alok S, Gupta N, Malik AK. An update on ayurvedic herb vishnukanta (Clitoria ternatea Linn.): A.
34.    Al-Snafi AE. Pharmacological importance of Clitoria ternatea–A review. IOSR Journal of Pharmacy. 2016 Mar; 6(3): 68-83.
35.    Jeyaraj EJ, Lim YY, Choo WS. Antioxidant, cytotoxic, and antibacterial activities of Clitoria ternatea flower extracts and anthocyanin-rich fraction. Scientific Reports. 2022 Sep 1; 12(1): 14890.

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