Ch. Nagabhushanam, P Ramesh babu, NK Durga Devi, A Vasu, Devala Rao.
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Ch. Nagabhushanam*1, P Ramesh babu2, NK Durga Devi1, A Vasu2 and G Devala Rao1
1K.V.S.R Siddhartha College of pharmaceutical sciences, Vijayawada-10
2P.Ramesh babu Citi Cardiac centre,Vijayawada-8.
Volume - 2,
Issue - 2,
Year - 2010
Obesity is an important health hazard a known risk factor for several diseases like coronary heart disease (CHD), angina pectoris hypertension, cardiac failure etc... Recent investigations and national cholesterol education program, adult treatment panel-III (NCEP, ATP-III) guidelines stating that the LDL-cholesterol is the primary target of treatment in clinical lipid management. In this manuscript to evaluate the safety and efficacy of Googol and Atorvastatin after excluding patients with exclusion criteria, thirty adult patients were allotted to study the medication. Randomly atorvastatin (20mg) was allotted to fifteen patients and guggulu (250mg) for fifteen patients for six weeks were allotted, before and after the treatment lipoprotein profile estimation was done. Weekly once checked for side effects. Out of thirty patients only twenty five were available for efficacy analysis (14 in guggulu group and 11 in atorvastatin group) the rest were dropouts. There is a satisfactory 7 significant reduction in LDL-cholesterol from the basic line value in atorvastatin group (29.5%) in comparison with guggul group (7%). HDL- cholesterol levels were raised in Atorvastatin group (4%) but there is no change in guggul group etc. By these results we can conclude that Atorvastatin is superior to guggul in lowering LDL-cholesterol and raising HDL-cholesterol.
Cite this article:
Ch. Nagabhushanam, P Ramesh babu, NK Durga Devi, A Vasu , Devala Rao.
A Comparative Randomized Study of Guggulu and Atorvastatin Hypercholesterolemia Patients. Research J. Pharmacology and Pharmacodynamics. 2010; 2(2):187-189.