Author(s): Ruchita I. Patil, Ruchika R. Patil, Nikhil N. Patil, Azam Z. Shaikh, Akash S. Jain, Divakar R. Patil, Sameer R. Shaikh, Hamid S. Hasani

Email(s): azamph46@gmail.com

DOI: 10.52711/2321-5836.2024.00055   

Address: Ruchita I. Patil*, Ruchika R. Patil, Nikhil N. Patil, Azam Z. Shaikh, Akash S. Jain, Divakar R. Patil, Sameer R. Shaikh, Hamid S. Hasani
Department of pharmaceutics P.S.G.V.P.Mandal’s College of Pharmacy, Shahada, Maharashtra - 425409, India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 4,     Year - 2024


ABSTRACT:
Medicinal plants have been valued for millennia for their therapeutic properties in preventing various ailments. Kidney stones and urinary calculi are increasingly prevalent due to changes in lifestyle such as industrialization and poor nutrition. In India, calcium oxalate kidney stones are the most common. This article examines the prevalence, types, and treatments for kidney stones, with a focus on the use of medicinal herbs. Medicinal herbs have been used for centuries because they are safer, more effective, culturally acceptable, and have fewer adverse effects compared to manufactured medications. Patients with kidney stones are advised to consume a low-fat diet and incorporate fibers from naturally occurring plants and herbal treatments into their regimen. The article outlines steps to maximize the potential of medicinal plants in dissolving kidney stones. Combining herbal remedies with allopathic treatments is suggested as an effective approach to address all issues associated with kidney stones. This integrated treatment method can leverage the strengths of both systems, providing a holistic and effective solution for kidney stone patients. The purpose of this article is to emphasize the benefits and applications of herbs in the treatment of urinary stones, advocating for their use alongside conventional medical treatments.


Cite this article:
Ruchita I. Patil, Ruchika R. Patil, Nikhil N. Patil, Azam Z. Shaikh, Akash S. Jain, Divakar R. Patil, Sameer R. Shaikh, Hamid S. Hasani. Formation and Herbal Prevention for Kidney Stone. Research Journal of Pharmacology and Pharmacodynamics. 2024;16(4):321-7. doi: 10.52711/2321-5836.2024.00055

Cite(Electronic):
Ruchita I. Patil, Ruchika R. Patil, Nikhil N. Patil, Azam Z. Shaikh, Akash S. Jain, Divakar R. Patil, Sameer R. Shaikh, Hamid S. Hasani. Formation and Herbal Prevention for Kidney Stone. Research Journal of Pharmacology and Pharmacodynamics. 2024;16(4):321-7. doi: 10.52711/2321-5836.2024.00055   Available on: https://rjppd.org/AbstractView.aspx?PID=2024-16-4-11


REFERENCE:
1.    Kidneys and the Urinary System: A Vital Network." Medical Journal, Volume 34, Issue 5, 2024; 34(5): 233-245. Published by the American Medical Association.
2.    Stamatelou KK, Francis ME, Jones CA, et al. Time trends in reported
3.    JM, Thun MJ, Coates RJ, et al. Demographic and geographic Variability of kidney stones in the United States. Kidney Int. 1994; 46(3): 893–899.
4.    Lee YH, Huang WC, Tsai JY, et al. Epidemiological studies on the Prevalence of upper urinary calculi in Taiwan. Urol Int. 2002; 68(3): 172–177.
5.    Safarinejad MR. Adult urolithiasis in a populationbased study in Iran: prevalence, incidence, and associated risk factors. Urol Res. 2007; 35(2): 73– 82.
6.    Scales CD Jr, Smith AC, Hanley JM, et al. Prevalence of kidney stones in The United States. Eur Urol. 2012; 62(1): 160165.
7.    Trinchieri A, Coppi F, Montanari E. Increase in the prevalence of Symptomatic upper urinary tract stones during the last ten years. Eur Urol. 2000; 37(11): 23–27.
8.    Daudon M, Frochot V, Bazin D and Jungers P: Drug induced Kidney stones and crystalline nephropathy: Pathophysiology, Prevention and treatment. Drugs 78: 163 201, 2018.
9.    Rodgers AL: Physicochemical mechanisms of stone formation. Urolithiasis 45: 27 32, 2017. 2
10.    Wang Z, Zhang JW, Zhang Y, Zhang SP, Hu QY and Liang H: Analyses of long non coding RNA and mRNA profiling using RNA sequencing in calcium oxalatemonohydrate stimulated Renal tubular epithelial cells. Urolithiasis 47: 225 234, 2019.
11.    Thongboonkerd V: Proteomics of crystal cell interactions: A model for kidney stone research. Cells 8: 1076, 2019.
12.    Wang Z, Li MX, Xu CZ, Zhang Y, Deng Q, Sun R, Hu QY, Zhang SP, Zhang JW and Liang H: Comprehensive study of Altered proteomic landscape in proximal renal tubular epithelial Cells in response to calcium oxalate monohydrate crystals. BMC Urol 20: 136, 2020.
13.    Fong Ngern K, Sueksakit K and Thongboonkerd V: Surface Heat shock protein 90 serves as a potential receptor for calcium Oxalate crystal on apical membrane of renal tubular epithelial Cells. J Biol Inorg Chem 21: 463 474, 2016.
14.    Kumar V, Farell G, Deganello S and Lieske JC: Annexin II Is present on renal epithelial cells and binds calcium oxalate Monohydrate crystals. J Am Soc Nephrol 14: 289 297, 2003.
15.    Anan G, Yoneyama T, Noro D, Tobisawa Y, Hatakeyama S, Sutoh Yoneyama M, Yamamoto H, Imai A, Iwamura H, Kohada Y, et al: The impact of glycosylation of osteopontin on Urinary stone formation. Int J Mol Sci 21: 93, 2019.
16.    Vezzoli G, Macrina L, Magni G and Arcidiacono T: Calcium sensing receptor: Evidence and hypothesis for its role In nephrolithiasis. Urolithiasis 47: 23 33, 2019.
17.    Farell G, Huang E, Kim SY, Horstkorte R and Lieske JC: Modulation of proliferating renal epithelial cell affinity for Calcium oxalate monohydrate crystals. J Am Soc Nephrol 15: 3052 3062, 2004.
18.    Gao J, Xue JF, Xu M, Gui BS, Wang FX and Ouyang JM: Nanouric acid or nanocalcium phosphate as central nidus to Induce calcium oxalate stone formation: A high resolution trans Mission electron microscopy study on urinary nanocrystallites. Int J Nanomedicine 9: 4399 4409, 2014. 3
19.    Shekarriz B and Stoller ML: Uric acid nephrolithiasis: Current Concepts and controversies. J Urol 168: 1307 1314, 2002.
20.    Song L and Maalouf NM: Nephrolithiasis. In: Endotext. Feingold KR, Anawalt B, Boyce A, Chrousos G, de Herder WW, Dungan K, Grossman A, Hershman JM, Hofland HJ, Kaltsas G, Et al (eds). MDText.com, Inc., South Dartmouth, MA, 2000.
21.    Farmanesh S, Chung J, Sosa RD, Kwak JH, Karande P and Rimer JD: Natural promoters of calcium oxalate monohydrate Crystallization. J Am Chem Soc 136: 12648 12657, 2014.
22.    Worcester EM: Urinary calcium oxalate crystal growth inhibitors. J Am Soc Nephrol 5 (Suppl 1): S46 S53, 1994.
23.    Schepers MS, van der Boom BG, Romijn JC, Schroder FH and Verkoelen CF: Urinary crystallization inhibitors do not prevent Crystal binding. J Urol 167: 1844 1847, 2002.
24.    Khan SR and Kok DJ: Modulators of urinary stone formation. Front Biosci 9: 1450 1482, 2004.
25.    Hess B, Jordi S, Zipperle L, Ettinger E and Giovanoli R: Citrate Determines calcium oxalate crystallization kinetics and crystal Morphology studies in the presence of Tamm Horsfall protein of A healthy subject and a severely recurrent calcium stone former. Nephrol Dial Transplant 15: 366 374, 2000.
26.    Kim D, Rimer JD and Asplin JR: Hydroxycitrate: A potential New therapy for calcium urolithiasis. Urolithiasis 47: 311 320, 2019.
27.    Chung J, Granja I, Taylor MG, Mpourmpakis G, Asplin JR and RimerJD: Molecular modifiers reveal a mechanism of pathological Crystal growth inhibition. Nature 536: 446 450, 2016. 4
28.    Ryall RL, Harnett RM and Marshall VR: The effect of urine, Pyrophosphate, citrate, magnesium and glycosaminoglycans on The growth and aggregation of calcium oxalate crystals in vitro. Clin Chim Acta 112: 349 356, 1981.
29.    Grases F, Rodriguez A and Costa Bauza A: Efficacy of mixtures of Magnesium, citrate and phytate as calcium oxalate crystallization Inhibitors in urine. J Urol 194: 812 819, 2015.
30.    Randall A: The origin and growth of renal calculi. Ann Surg 105: 1009 1027, 1937.
31.    Wiener SV, Chen L, Shimotake AR, Kang M, Stoller ML and Ho SP: Novel insights into renal mineralization and stone forma Tion through advanced imaging modalities. Connect Tissue Res 59: S102 S110, 2018.
32.    Daudon M, Bazin D and Letavernier E: Randall’s plaque as the Origin of calcium oxalate kidney stones. Urolithiasis 43 (Suppl 1) S5 S11, 2015.
33.    Khan SR, Canales BK and Dominguez Gutierrez PR: Randall’s Plaque and calcium oxalate stone formation: Role for immunity and inflammation. Nat Rev Nephrol 17: 417 433, 2021.
34.    Bouderlique E, Tang E, Perez J, Coudert A, Bazin D, Verpont MC, Duranton C, Rubera I, Haymann JP, Leftheriotis G, et al: Vitamin D And calcium supplementation accelerates Randall’s plaque forma Tion in a murine model. Am J Pathol 189: 2171 2180, 2019
35.    Fan J, Chandhoke PS and Grampsas SA: Role of sex hormones in experimental calcium oxalate nephrolithiasis. J Am Soc Nephrol 10 (Suppl 14): S376 S380, 1999
36.    Yoshihara H, Yamaguchi S and Yachiku S: Effect of sex Hormones on oxalate synthesizing enzymes in male and female Rat livers. J Urol 161: 668 673, 1999.
37.    Liang L, Li L, Tian J, Lee SO, Dang Q, Huang CK, Yeh S, Erturk E, Bushinsky D, Chang LS, et al: Androgen receptor Enhances kidney stone CaOx crystal formation 5 via modulation of oxalate biosynthesis & oxidative stress. Mol Endocrinol 28:1291 1303, 2014.
38.    Bichler KH, Eipper E, Naber K, Braun V, Zimmermann R and Lahme S: Urinary infection stones. Int J Antimicrob Agents 19: 488 498, 2002.
39.    Espinosa Ortiz EJ, Eisner BH, Lange D and Gerlach R: Current Insights into the mechanisms and management of infection Stones. Nat Rev Urol 16: 35 53, 2019.
40.    Marien T and Miller NL: Treatment of the Infected Stone. Urol Clin North Am 42: 459 472, 2015.
41.    De Cógáin MR, Lieske JC, VrtiskaTJ, Tosh PK and Krambeck AE: Secondarily infected nonstruvite urolithiasis: A prospectiveEvaluation. Urology 84: 1295 1300, 2014.
42.    Flannigan R, Choy WH, Chew B and Lange D: Renal struvite Stones pathogenesis, microbiology, and management strategies. Nat Rev Urol 11: 333 341, 2014.
43.    Nikolic Paterson DJ, Wang S and Lan HY: Macrophages Promote renal fibrosis through direct and indirect mechanisms. Kidney Int Suppl (2011) 4: 34 38, 2014.
44.    Okada A, Yasui T, Fujii Y, Niimi K, Hamamoto S, Hirose M, Kojima Y, Itoh Y, Tozawa K, Hayashi Y and Kohri K: Renal Macrophage migration and crystal phagocytosis via inflammation Matory related gene expression during kidney stone formation and elimination in mice: Detection by association analysis of Stone related gene expression and microstructural observation. J Bone Miner Res 25: 2701 2711, 2010.
45.    Singhto N, Kanlaya R, Nilnumkhum A and Thongboonkerd V: Roles of macrophage exosomes in immune response to calcium Oxalate monohydrate crystals. Front Immunol 9: 316, 2018. 6
46.    Dominguez Gutierrez PR, Kusmartsev S, Canales BK and Khan SR: Calcium oxalate differentiates human monocytes into Inflammatory M1 macrophages. Front Immunol 9: 1863, 2018.
47.    https:// my – cleveland clinic.org/health / diseases / 15604 kidney stones. 48)Ettinger B, Citron JT, Livermore B, et al. Chlorthalidone reduces calcium Oxalate calculous recurrence but magnesium hydroxide does not. J Urol.1988; 139(4): 679–984.
48.    Ettinger B, Citron JT, Livermore B, et al. Chlorthalidone reduces calcium Oxalate calculous recurrence but magnesium hydroxide does not. J Urol. 1988; 139(4): 679–984
49.    Bashir, S., Gilani, A.H., et al, Berberis vulgaris Root Bark Extract Prevents Hyperoxaluria Induced Urolithiasis in Rats, Phytother Res, 2004; 1250-55
50.    Hadizadeh, M.A., Khoei, A., et al, Ethanolic Extract of Nigella Sativa L. Seeds on Glycol-Induced Kidney Calculi in Rats, Urol J., 2007; 4(2): 86-90
51.    Barros, M., Lima, R., et al, Effect of Extract of Phyllanthus niruri On Crystal Deposition in Experimental Urolithiasis, Urol Res., 2006; 34: 51-357
52.    Rodgers, A., Lewandowski, S., et al, Evening Primrose Oil Supplementation Increases Citraturia and Decreases Other Urinary Risk Factors for Calcium Oxalate Urolithiasis, J Urol, 2009; 182(6): 2956-63
53.    Grases, F., Prieto, R.M., et al, Phytotherapy and Renal Stones: The Role of Antioxidants. A Pilot Study in Wistar Rats, Urol Res., 2009; 37(1): 35-40
54.    Laroubi, A., Touhami, M., et al, Prophylaxis Effect of Trigonella Foenum graecum L. Seeds on Renal Stone Formation in Rats, Phytotherapy Research, 2007; 21, 921-925
55.    Williamson, E., Major Herbs of Ayurveda, Churchill Livingstone, Edinborough, 2002
56.    Aggarwal, A., Tandon, S., et al, Diminution of Oxalate Induced Renal Tubular Epithelial Cell Injury and Inhibition Of Calcium Oxalate Crystallization In Vitro by Aqueous Extract of Tribulus terrestris, International Braz J Urol, 2010; 36(4): 480- 489
57.    Woottisin, S., Hossain, R.Z., et al, Effects of Orthosiphon Grandiflorus, Hibiscus sabdariffa and Phyllanthus amarus Extracts on Risk Factors for Urinary Calcium Oxalate Stones In Rats, J Urol, 2011; 185: 323-328
58.    Prasongwatana, V., Woottisin, S., et al, Uricosuria Effect of Roselle (Hibiscus sabdariffa) in Normal and Renal-Ston
59.    Hirayama, H., Wang, Z, et al, Effect of Desmodium styracifolium-Triterpenoid on Calcium Oxalate Renal Stones, Br J Urol,1993;71(2):143-7
60.    Grases, F., Masarova, L., et al, Effect of “Rosa canina” Infusion And Magnesium on The Urinary Risk Factors of Calcium Oxalate Urolithiasis, Planta Med, 1992; 58(6): 509-12
61.    Atmani, F., Slimani, Y., et al, Effect of Aqueous Extract From Herniaria hirsuta L. on Experimentally Nephrolithiasic Rats,J Ethmopharmacol, 2004; 95(1): 87-93
62.    Christina, A.J., Ashok, K., et al, Antilithiatic Effect of Asparagus Racemosus Willd on Ethylene Glycol-Induced Lithiasis in Male Albino Wistar Rats, Methods Find Exp Clin Pharmacol, 2005; 27(9): 633-8
63.    Prasad, K.V.S.R.G., Sujatha, D. et al, Herbal Drugs in Urolithiasis-A Review, Phcog Rev., 2007; 1(1): 175-179 8
64.    Cao, Z.G., Liu, J.H., et al, An Experimental Study of Effect of Different Extracts of Alisma orientalis on Urinary Calcium Oxalate Stones Formation in Rats [In Chinese], Zhongguo Zhong Yao Za Zi, 2003; 28(11): 1072-5
65.    Chou-Huang, T., Yu-Cheng, C., et al, A Traditional Herbal Antilithic Formula, Wulingsan, Effectively Prevents the Renal Deposition of Calcium Oxalate Crystal in Ethylene Glycol-Fed Rats, Urol Res, 2008; 36:17-2

Recomonded Articles:

Author(s): Upadhyay SU, Jain VC, Upadhyay UM.

DOI: 10.5958/2321-5836.2015.00021.X         Access: Open Access Read More

Author(s): R Badmanaban, CN Patel, P Devi, DJ Sen, KM Modh.

DOI: Not Available         Access: Open Access Read More

Author(s): K Geetha, R Manavalan, D Venkappaya

DOI: Not Available         Access: Open Access Read More

Author(s): Krupasagar P.N., Shekshavali T., Chethan M.L., Ganesh D.S.

DOI: 10.52711/2321-5836.2024.00041         Access: Open Access Read More

Author(s): Ruchita I. Patil, Ruchika R. Patil, Nikhil N. Patil, Azam Z. Shaikh, Akash S. Jain, Divakar R. Patil, Sameer R. Shaikh, Hamid S. Hasani

DOI: 10.52711/2321-5836.2024.00055         Access: Closed Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 

Journal Policies & Information




Recent Articles




Tags