Author(s): R. Sathish, G. Jeyabalan

Email(s): rsvsathish2000@yahoo.co.in

DOI: 10.5958/2321-5836.2018.00001.0   

Address: R. Sathish*, G. Jeyabalan
Department of Pharmacy, Sunrise University, Alwar, Rajasthan, India.
*Corresponding Author

Published In:   Volume - 10,      Issue - 1,     Year - 2018


ABSTRACT:
The present day medical management of lithiasis is either costly or not without side effects, hence the search for anti lithiatic drugs from natural sources has assumed greater importance. The anti-lithiatic activity of Ipomoea batatas leaves and tuberous roots at 200 and 400mg/kg doses in curative and preventive regimens were evaluated on ethylene glycol induced lithiasis in male wistar rats. Lithiasis was induced in rats by 0.75% ethylene glycolated water ad libitum for 28 days. On 28th day urinary excretion of calcium, oxalate, phosphate, uric acid and protein were significantly (p<0.01) decreased and magnesium excretion was significantly (p<0.01) increased in both curative and preventive regimens of I.batatas leaves and tuberous roots when compared with lithiatic control animals. The significant reduction (p<0.01) of serum creatinine, uric acid, blood urea nitrogen levels and significant increase (p<0.01) in creatinine clearance were also produced by I.batatas leaves and roots in both curative and preventive regimens. The I. batatas leaves and roots supplementation also caused significant (p<0.01) diuresis in rats accompanied by increased diuretic index. The maximum responses were produced by ethanolic extract of I.batatas tuberous roots and the effects were significantly (p<0.01) more than that of ethanolic extract of I.batatas leaves in both preventive and curative regimens. These observations concluded that the I.batatas roots (sweet potato) can be used as a herbal remedy in the treatment of lithiasis.


Cite this article:
R. Sathish, G. Jeyabalan. Anti- Lithiatic Effect of Ipomoea batatas (L) Leaves and Tuberous Roots on Ethylene Glycol Induced Urolithiasis in Rats. Res. J. Pharmacology and Pharmacodynamics.2018; 10(1): 01-07. doi: 10.5958/2321-5836.2018.00001.0


Recomonded Articles:

Author(s): Upadhyay SU, Jain VC, Upadhyay UM.

DOI: 10.5958/2321-5836.2015.00021.X         Access: Open Access Read More

Author(s): Ajay Kr Meena, Brijendra Singh, Uttam Singh, Ajay Kr. Yadav, Amit Nagariya, Kiran Sharma.

DOI: Not Available         Access: Open Access Read More

Author(s): K Geetha, R Manavalan, D Venkappaya

DOI: Not Available         Access: Open Access Read More

Author(s): Bhagwan Gamaji Ambhore, Kavita Ambhore, Dilip N Dhekale.

DOI: Not Available         Access: Open Access Read More

Author(s): Jhakeshwar Prasad, S. Prakash Rao, Ashish Kumar Netam, Trilochan Satapathy

DOI: 10.5958/2321-5836.2018.00024.1         Access: Open Access Read More

Author(s): Patel Hirenkumar R.

DOI: Not Available         Access: Open Access Read More

Author(s): G. Swapna, J. Poojitha, B. Pravallika

DOI: 10.5958/2321-5836.2019.00027.2         Access: Closed Access Read More

Author(s): Aathira Menon, Apthadevi, Roshni P R

DOI: 10.5958/2321-5836.2019.00021.1         Access: Closed Access Read More

Author(s): Arya B, Krishnaveni K, Sambathkumar R

DOI: 10.5958/2321-5836.2020.00005.1         Access: Closed Access Read More

Author(s): G. Swapna, B. Pravallika, J. Poojitha

DOI: 10.5958/2321-5836.2019.00026.0         Access: Closed Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags