Author(s): Sanjay Kumar Chintakayala, Aalekhya Ravipati, Vinod Kumar Mugada, Srinivasa Rao Yarguntla

Email(s): sanjaykumarchintakayala@gmail.com

DOI: 10.52711/2321-5836.2023.00033   

Address: Sanjay Kumar Chintakayala1*, Aalekhya Ravipati1, Vinod Kumar Mugada1, Srinivasa Rao Yarguntla2
1Department of Pharmacy Practice, Vignan Institute of Pharmaceutical Technology, Duvvada, AP, India.
2Department of Pharmaceutics, Vignan Institute of Pharmaceutical Technology, Duvvada, AP, India.
*Corresponding Author

Published In:   Volume - 15,      Issue - 4,     Year - 2023


ABSTRACT:
PDB is a long-standing pathological stateillustrated by aberrant bone remodeling and metabolism arising in structural anomalies of the bone tissue. While this disease may remain asymptomatic, mild symptoms such as joint and bone discomfort may be present. However, an early warning sign is intense nocturnal bone pain. Moreover, PDB may result in complications such as deafness, fractures, compression of cranial nerves or the spinal cord, and hydrocephalus. This disease is more frequently observed in individuals above the age of 50, affecting individuals of all races and ethnicities, with a slightly higher prevalence in males. Diagnosis of PDB involves comprehensive clinical assessment, patient history, and specialized tests. Pharmacological treatments such as bisphosphonates, calcitonin, and surgical intervention may be employed to manage the disease. Supplementation is essential to prevent hypocalcemia. PDB may lead to rare complications, including sarcomatous conversion of the pagetic lesion and high-output congestive heart failure which concerns healthcare professionals.


Cite this article:
Sanjay Kumar Chintakayala, Aalekhya Ravipati, Vinod Kumar Mugada, Srinivasa Rao Yarguntla. A Comprehensive Guide to Paget’s Disease of Bone. Research Journal of Pharmacology and Pharmacodynamics.2023;15(4):186-0. doi: 10.52711/2321-5836.2023.00033

Cite(Electronic):
Sanjay Kumar Chintakayala, Aalekhya Ravipati, Vinod Kumar Mugada, Srinivasa Rao Yarguntla. A Comprehensive Guide to Paget’s Disease of Bone. Research Journal of Pharmacology and Pharmacodynamics.2023;15(4):186-0. doi: 10.52711/2321-5836.2023.00033   Available on: https://rjppd.org/AbstractView.aspx?PID=2023-15-4-7


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