Ambika Nand Jha, Dhaval M. Patel, Jignesh S Patel, Upama N. Trivedi, Akshay H. Shah
Ambika Nand Jha1*, Dhaval M. Patel2, Jignesh S Patel3, Upama N. Trivedi4, Akshay H. Shah4
1Doctor of Pharmacy, Department of Pharmacy Practice, Indubhai Patel College of Pharmacy and Research Centre, Dharmaj Anand Gujarat. 388430.
2Department of Pharmacology, SAL Institute of Pharmacy, Ahmedabad, Gujarat 380060.
3Department of Pharmaceutics Indubhai Patel College of Pharmacy and Research Centre, Dharmaj Anand Gujarat. 388430.
4Department of Pharmacology, Indubhai Patel College of Pharmacy and Research Centre, Dharmaj Anand Gujarat. 388430.
Volume - 13,
Issue - 2,
Year - 2021
The Cord blood is the blood from the baby that is left in the umbilical cord and placenta postpartum. Cord blood contains all the normal elements of blood-red blood cells, white blood cells, platelets and plasma. But it is also rich in haematopoietic stem cells, similar to those found in the bone marrow. Haematopoietic stem cell cells that can be used to treat some types of diseases. The first successful transplantation using haematopoietic stem cells from cord blood was performed in 1988 by a team lead by Dr E. Gluckman to treat a five-year-old boy suffering from Fanconi’s anaemia. It has been estimated that more than 35,500 transplants have been performed in children and adults for the correction of inborn errors of metabolism, hematopoietic malignancies, and genetic disorders of the blood and immune system. The umbilical cord is a narrow tube-like structure that connects the growing baby to the placenta. The cord is sometimes called the baby's “supply line” because it carries the baby's blood back and forth, between the baby and the placenta. It delivers nutrients and oxygen to the baby and excretes the baby's waste products. Three cord blood banking options are available public, private and direct donation banks. The protocols and standards for screening collections and storage of cord blood have now been established worldwide for both public and private cord blood banks. The use of cord blood provides viable options for paediatric patients with malignant conditions, hemoglobinopathies, metabolic disorders, immune deficiencies and regenerative applications.
Cite this article:
Ambika Nand Jha, Dhaval M. Patel, Jignesh S Patel, Upama N. Trivedi, Akshay H. Shah. Umbilical Cord Blood banking and its Therapeutic uses: A Review. Research Journal of Pharmacology and Pharmacodynamics. 2021; 13(2):55-8. doi: 10.52711/2321-5836.2021.00012
Ambika Nand Jha, Dhaval M. Patel, Jignesh S Patel, Upama N. Trivedi, Akshay H. Shah. Umbilical Cord Blood banking and its Therapeutic uses: A Review. Research Journal of Pharmacology and Pharmacodynamics. 2021; 13(2):55-8. doi: 10.52711/2321-5836.2021.00012 Available on: https://rjppd.org/AbstractView.aspx?PID=2021-13-2-6
1. Sadler, T. a. (2006). Langman's medical embryology (12 ed.). Philadelphia: Wolters Kluwer Health / Lippincott Williams and Wilkin.https: //www.ncbi.nlm.nih.gov/nlmcatalog/101562744
2. Phuc Van Pham, N. B.-B.-T.-T. Good manufacturing practice-compliant isolation and culture of human umbilical cord blood-derived mesenchymal stem cells. Journal of Translational Medicine, 2014:12(56). https://translationalmedicine. biomedcentral.com/articles/10.1186/1479-5876-12-56
3. Carroll, P. a. New and underutilized uses of umbilical cord blood in neonatal care. MaternalHealth, Neonatology and Perinatology. 2015.
4. Umbilical cord blood banking. ACOG Committee Opinion No. 771.American College of Obstetricians and Gynecologists. Obstet Gynecol 2019;133:e249–53. https://www.acog.org/clinical/ clinicalguidance/committeeopinion/articles/2019/03/umbilical-cord-blood-banking
5. Advantages and Disadvantages of Cord Blood Treatment. (2017). Retrieved December 20,2017, from Disabled World:https://www.disabledworld.com/news/research/stemcells/cord-bloodtreatment.php
6. Maslova, O. N. (2015). Umbilical Cord Tissue-Derived Cells as Therapeutic Agents. Stem CellsInternational, 1-10.
7. Are there and unfavorable aspects of cord blood? - National Cord Blood Program. Retrieved December 20, 2017, from ationalcordbloodprogram.org:http://www.nationalcordbloodprogram.org/qa/how_is_it_collected.html
8. Lauber S, Latta M, Kluter H, Muller-Steinhardt M. The Mannheim cord blood bank: experiences and perspectives for the future. Transfus Med Hemother. 2010; 37: 90–7.
9. Bizzetto R, Bonfim C, Rocha V. Outcomes after related andunrelated umbilical cord blood transplantation for heredity bonemarrow failure syndromes other than Fanconi anemia. Haematologica. 2011; 96:134–41.
10. Cohen YC, Scaradavou A, Stevens CE. Factors affecting mortalityfollowing myeloablative cord blood transplantation in adults: apooled analysis of three international registries. Bone Marrow Transplant. 2011; 46: 70–6.
11. Eapen M, Rocha R, Sanz G, Scaradavou A, Zhang M, Arcese W,et al. Effect of graft source on unrelated donor haemopoietic stem-cell transplantation in adults with acute leukaemia: a retrospectiveanalysis. Lancet Oncol. 2010; 11: 653–60.
12. O’Connor MA, Samuel G, Jordens CF, Kerrodge IH. Umbilical cord blood banking: beyond the public-privatedivide. J Law Med. 2012; 19: 512-6.
13. Public cord blood banking in India. Available from: https://parentsguidecordblood.org/en/public-banking/india. Accessed January 21, 2018.
14. Butler, M. a. Umbilical cord blood banking: an update. ournal of Assisted Reproduction and Genetics, 2011; 28(8): 669-676. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3170109/
15. Lubin BH, S. W. Cord blood banking for potential future transplantation. Pediatrics, 2007; 119 (1):165-70. https://www.ncbi.nlm.nih.gov/pubmed/17200285
16. Roura, S. P.-M.-G. The role and potential of umbilical cord blood in an era of new therapies: a review. Stem Cell Research And Therap, 2015; 6(123). https://www.ncbi.nlm.nih.gov/pmc/articles/ PMC4489204/
17. Moghul, S. N. Importance Of Umbilical Cord Blood. Retrieved June 29, 2017, from https://www.indiatimes.com/health/ healthyliving/importance-ofumbilical-cord-blood240702.html
18. Waller-Wise, R. Umbilical Cord Blood. Journal of Perinatal Education, 2011; 20(1): 54-60. https://www.ncbi.nlm.nih.gov/pmc/ articles/PMC3209739/
19. G.H. Mamoury, A. H. Cord Hemoglobin in Newborns in Correlation with Maternal Hemoglobin in Northeastern Iran. International Journal of Molecular Sciences, 2003; 28 (3): 166-168.