Author(s): Madhuri Yadav

Email(s): yadavmadhurigr8@gmail.com

DOI: 10.5958/2321-5836.2018.00027.7   

Address: Madhuri Yadav
Department of Zoology, School of Life Sciences, Khandari Campus, Dr. B. R. Ambedkar University, Agra
*Corresponding Author

Published In:   Volume - 10,      Issue - 4,     Year - 2018


ABSTRACT:
Air pollution has become a serious environmental issue and a threat to all over the world. SO2 is considered as the most poisonous and irritant gas as it penetrates deeper in the vitals hence alters the physiology, biochemistry and behavior of the living individuals. The present study has been designed to explore out the protective effect of Aloe vera against SO2 induced hepatotoxicity in albino rats. The twenty albino rats were grouped in four sets-control set (1) were kept in control conditions, while, experimental set (2) was exposed to 80ppm of SO2 gas 1h/d for 30 and 60 days, experimental set (3) were exposed to 80ppm of SO2 gas 1h/d with oral administration of Aloe vera fruits extracts (200mg/kg b.wt.) for 30 and 60 days respectively. The findings of the present investigation have indicated that SO2 causes significant increase in total bilirubin (p<0.05), conjugated bilirubin (p<0.05) but non-significant increase in unconjugated bilirubin level in liver as well as significant decrease in serum total protein (p<0.001), serum albumin (p<0.05), globulin (p<0.05), besides, significant increase in serum enzymes AST(p<0.01), ALT(p<0.001), GGT(p<0.01) and ALP (p<0.001) in liver of albino rats. Oral administration of Aloe vera recovers all these alterations at their normal level which is an indication of remedial effect of A. vera on SO2 induced hepatotoxicity.


Cite this article:
Madhuri Yadav. Detrimental effects of Sulphur Dioxide Gas on Liver Parameters and its Modulation by Aloe Vera. Res. J. Pharmacology & Pharmacodynamics.2018; 10(4): 149-155. doi: 10.5958/2321-5836.2018.00027.7


Recomonded Articles:

Author(s): Shameer Pasha, Mohamed Khaleel, Sukhen Som.

DOI: Not Available         Access: Open Access Read More

Author(s): Aswani P. S., Kshirod Kumar Ratha, Dighe Dattatray Pandurang, M. M. Rao, Remya Vijayan

DOI: 10.5958/2321-5836.2018.00008.3         Access: Open Access Read More

Author(s): Nadiminti Satish Reddy, Vidyasabbani, B. Pravanthi, B. Vijaya Laxmi, B. Harika.

DOI: 10.5958/2321-5836.2016.00023.9         Access: Open Access Read More

Author(s): U. S. Jijith , C. R. Sudhakaran Nair, K. Pramod

DOI: 10.5958/2321-5836.2016.00001.X         Access: Open Access Read More

Author(s): Kadiri Sunil Kumar, S Mounica, Rajesh Behera, K Vijay Kumar, Y Shanmukh Sai, R Suthakaran

DOI: 10.5958/2321-5836.2016.00013.6         Access: Open Access Read More

Author(s): Palaksha M. N., Ravishankar K, Vijaya Nandini

DOI: 10.5958/2321-5836.2017.00008.8         Access: Open Access Read More

Author(s): MA Halkai, Arun Patil, MD Akhil Ahmed, AK Beknal .

DOI: 10.5958/2321-5836.2016.00004.5         Access: Open Access Read More

Author(s): Kimbi, RB Ambola, Nabila VS Ajong, Emmanuel N Tufon

DOI:         Access: Open Access Read More

Author(s): Rohit J. Bhor, Harshala Damdhar, Geeta Kokate, Maduri Salve, Swati Andhale

DOI: 10.5958/2321-5836.2016.00025.2         Access: Open Access Read More

Author(s): Suneel Kumar A, Venkatarathanamma. V, Naga Saibabu V, Nageswara Rao Tentu, Pavan Kumar Kota, K. Suneel Kumar, A. Vijayalakshmi

DOI: 10.5958/2321-5836.2017.00009.X         Access: Open Access Read More

Author(s): Jadhav Anil G, Narkhede Sachin B, Patil Mrutyunjay B, Vidyasagar G.

DOI: Not Available         Access: Open Access Read More

Author(s): Satish Narra, Bandenawaz Ramadurg, Saraswathi C D.

DOI: Not Available         Access: Open Access Read More

Author(s): Suryawanshi CP, Patil VR, Chaudhari RY, Kale MK, Firake SD, Pimprikar RB, Patil MD, Yeshwante SB, Saindanem DS.

DOI: Not Available         Access: Open Access Read More

Author(s): Sathyaseelan Thennarasan, Subbiah Murugesan, Vajiravelu Sivamurugan

DOI: 10.5958/2321-5836.2017.00011.8         Access: Open Access Read More

Author(s): Kuchake VG, Patil PH, Mahajan HS, Ingle PV, Surana SJ, Thakare MM, S Sudharshini.

DOI: Not Available         Access: Open Access Read More

Author(s): Olukayode Olugbenga Orole, Gerard O. Uyi, Ayofemi F. Gbadeyan

DOI: 10.5958/2321-5836.2016.00027.6         Access: Open Access Read More

Author(s): Kashnia AR, KL Senthilkumar, T Karthiyayini, K Senthilkumar

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags