Research Journal of Pharmacology and Pharmacodynamics

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2321-5836 (Online)
0975-4407 (Print)


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Amelioration of Gastric Lesions by Avocado (Persea americana) fruit extract on Indomethacin as well as Ethanol induced Ulcerated Experimental rats

Author(s): U.S. Mahadeva Rao, Bizuneh Adinew

Email(s): raousm@gmail.com

DOI: Not Available

Address: U.S. Mahadeva Rao and Bizuneh Adinew
Department of Chemistry, Mizan-Tepi University, P. O. No 121, Tepi, Ethiopia, East Africa
*Corresponding Author

Published In:   Volume - 2,      Issue - 4,     Year - 2010

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ABSTRACT:
In the present study, anti-ulcerogenic potential of Avocado fruit extract was evaluated using two different models of gastric lesions induced in experimental rats; 1) Indomethacin-induced gastric lesions and 2) Ethanol-induced gastric lesions. Pretreatment with oral administration of the extract of Avocado fruit extract (300mg/kg) prevented the formation of acute gastric lesion induced by both the experimental models: further, treatment with the ethanolic extract of Avocado fruit extract for a period of 15 days significantly reduced the ulcer index, ulcerated surface and significantly elevated the levels of glycoprotein contents in gastric juice.


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Cite this article:
U.S. Mahadeva Rao and Bizuneh Adinew. Amelioration of Gastric Lesions by Avocado (Persea americana) fruit extract on Indomethacin as well as Ethanol induced Ulcerated Experimental rats. Research J. Pharmacology and Pharmacodynamics. 2010; 2(4): 303-308.

Cite(Electronic):
U.S. Mahadeva Rao and Bizuneh Adinew. Amelioration of Gastric Lesions by Avocado (Persea americana) fruit extract on Indomethacin as well as Ethanol induced Ulcerated Experimental rats. Research J. Pharmacology and Pharmacodynamics. 2010; 2(4): 303-308.   Available on: https://rjppd.org/AbstractView.aspx?PID=2010-2-4-22


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Research Journal of Pharmacology and Pharmacodynamics (RJPPD) (ISSN: print-0975-4407, online- 2321-5836) is an international, peer-reviewed journal, devoted to Pharmacology, Pharmacodynamics and Medical Sciences. The aim of RJPPD is to increase the impact of pharmacological research both in academia and industry, with strong emphasis on quality and originality. RJPPD publishes Original research Articles, Short Communications, Review Articles in all areas of pharmacology, pharmacokinetics and human physiology.

The journal is published quaterly every year in last week of March, June, September and December (i.e. 4 issues in each calendar year).    
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