Author(s): Kale Rupali C, Gadgil Swati S, Borole Kanchan D, Wele Asmita A

Email(s): vd.swatigadgil@gmail.com

DOI: 10.5958/2321-5836.2015.00030.0   

Address: Kale Rupali C.1, Gadgil Swati S.2*, Borole Kanchan D.3, Wele Asmita A.4
1Ayurved Practitioner, Pune
2Assistant Professor, Department of Rasashastra Bhaishajyakalpana, College of Ayurved, Bharati Vidyapeeth Deemed University, Pune.
3Assistant Professor, Pharmacology Dept., Bharati Vidyapeeth Deemed University, Medical College, Pune.
4Professor and HOD, Department of Rasashastra Bhaishajyakalpana and Dean, Bharati Vidyapeeth Deemed University, College of Ayurved, Pune.
*Corresponding Author

Published In:   Volume - 7,      Issue - 4,     Year - 2015


ABSTRACT:
Amalakyadi Ghrita (AG) a ghee based formulation is recommended for the treatment of Apasmar (Epilepsy) in Ayurved. Present study has been designed to prepare standard Amalakyadi Ghrita and evaluate it’s antiepileptic activity using animal models namely Maximal Electricshock Seizures (MES) and Pentelenetetrazole (PTZ) induced seizure. It has been prepared, standardised using analytical tests and subjected to preliminary phytochemical analysis. Control drug, i.e. Cow ghee 5gm/kg, Standard drug, i.e. Phenytoin 25mg/kg and AG at three dose levels 2.5gm/kg, 5gm/kg and 10gm/kg. were administered orally in all the models. Mean values and standard error of mean was determined for all models and data was analyzed by one-way ANOVA, followed by Dunnett’s test. Preliminary phytochemical analysis of AG showed presence of alkaloids, phenols, tannins and flavonoids. AG at medium and higher dose exhibited significant antiepileptic activity in MES model by decreasing the duration of tonic extensor phase (p<0.001). In PTZ model, AG at higher dose, significantly delayed the onset of convulsions (p<0.05). AG has shown significant anticonvulsant activity in both the study models. The presence of different phyto constituents in the formulation may singularly or in combination be responsible for this activity.


Cite this article:
Kale Rupali C, Gadgil Swati S, Borole Kanchan D, Wele Asmita A . Experimental Evaluation of Antiepileptic Activity of Amalakyadi Ghrita. Research Journal of Pharmacology and Pharmacodynamics. 2015; 7(4): 155-160. doi: 10.5958/2321-5836.2015.00030.0


Recomonded Articles:

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, GC Bhuyna, BK Das, MM Rao.

DOI: 10.5958/2321-5836.2016.00008.2         Access: Open Access Read More

Author(s): Aswani P. S., Kshirod Kumar Ratha, Dighe Dattatray Pandurang, M. M. Rao, Remya Vijayan

DOI: 10.5958/2321-5836.2018.00008.3         Access: Open Access Read More

Author(s): Jeevanagouda Patil, Kuppast I.J, Kishan Kumar M A, Kishan K G

DOI: 10.5958/2321-5836.2016.00032.X         Access: Open Access Read More

Author(s): M. Vanajakshi, J.H. Virupaksha, Shilpa Maria

DOI: 10.5958/2321-5836.2016.00033.1         Access: Open Access Read More

Author(s): Sudhanshu Kumar Meher, Banmali Das, Purnendu Panda, GC Bhuyan, MM Rao.

DOI: 10.5958/2321-5836.2016.00006.9         Access: Open Access Read More

Author(s): Nikhil P. Varghese, Shekshavali T. , Prathib B., I.J. Kuppast

DOI: 10.5958/2321-5836.2017.00007.6         Access: Open Access Read More

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, Das, GC Nanda.

DOI: Not Available         Access: Open Access Read More

Author(s): Banamali Das, Purnendu Panda, SK Meher, GC Bhuyan, DS Sahu, Bikartan Das, G Ch D Nagalakshmi, MM Rao.

DOI: 10.5958/2321-5836.2015.00010.5         Access: Open Access Read More

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, BK Das, MM Rao, GChD Naga Lakshmi.

DOI: 10.5958/2321-5836.2015.00011.7         Access: Open Access Read More

Author(s): Sudhanshu Kumar Meher, P K Mukherjee, S K Banarjee Chaudhury, Bani Marjit, B PShaw.

DOI: 10.5958/2321-5836.2016.00014.8         Access: Open Access Read More

Author(s): M Lavanya, Asish Bhaumik, A Gopi Reddy, Ch Manasa, B Kalyani, S Sushmitha

DOI: 10.5958/2321-5836.2016.00012.4         Access: Open Access Read More

Author(s): Srinibash Sahoo, BCS Rao, AK Das, Kamadev Das.

DOI: Not Available         Access: Open Access Read More

Author(s): Sanjib Kumar Das, Anuradha Das, Banamali Das, Purnendu Panda, G. C. Bhuyan, Bipin Bihari Khuntia

DOI: 10.5958/2321-5836.2017.00036.2         Access: Open Access Read More

Author(s): Madhavi Sahu, S. Prakash Rao

DOI: 10.5958/2321-5836.2018.00031.9         Access: Closed Access Read More

Author(s): Juna Thomas, Veeresh Babu D, Anjan Kumar, Narayana Swamy V B.

DOI: 10.5958/2321-5836.2016.00009.4         Access: Open Access Read More

Author(s): Syed Shafeeq. R, Shekshavali. T, Syed Sulthan Ahamed. S N

DOI: 10.5958/2321-5836.2018.00026.5         Access: Open Access Read More

Author(s): Ajay Kumar Meena, Himanshu Sehgal, MM Rao, P Panda, MM Padhi.

DOI: Not Available         Access: Open Access Read More

Author(s): D. Benito Johnson, Faisal N.V, Rashid. K, Mohammed Haleel, V. Venkatanarayanan

DOI: 10.5958/2321-5836.2016.00018.5         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags