Author(s): Juna Thomas, Veeresh Babu D, Anjan Kumar, Narayana Swamy V B.

Email(s): veeresan111@gmail.com

DOI: 10.5958/2321-5836.2016.00009.4   

Address: Juna Thomas1*,Veeresh Babu. D1, Anjan Kumar1, Narayana Swamy V.B2
1Department of Pharmacology, Karavali College of Pharmacy, Mangalore.
2Department of Pharmacognosy, Karavali College of Pharmacy, Mangalore.
*Corresponding Author

Published In:   Volume - 8,      Issue - 2,     Year - 2016


ABSTRACT:
Aim: The present study was designed to evaluate the anti depressant activity of a Poly herbal formulation “PERMENT” in experimental animal models. Method: Anti depressant activity was evaluated in experimental different either sex animal models. The degree of anti depressant activity was determined by measuring the immobility time in Forced swim test and Tail suspension test, by counting the number of failure to escape and number of avoidance response in Learned helplessness test, Reserpine induced test the rectal temperature is determined and the number of passages of rodents through the hole from one chamber to another in Hole cross as a confirmatory test. Result: Animals treated with all three doses of PERMENT (53.85, 102.77 and 154.16mg/kg) witnessed a decrease in their immobility times in FST and TST which was significant when compared with control. Similarly, animals treated with Imipramine (15mg/kg), as expected showed a significant decrease in the immobility time. In learned Helplessness Test, the PERMENT treated rats showed significant increase in avoidance response and decreased in escape failure in response to shock treatment. In Reserpine Induced Test the initial rectal temperature is determined by electronic thermometer. Hole cross test utilizes the number of passages of rodents through the hole from one chamber to another . Conclusion: The study revealed that the “PERMENT” possess a significant anti depressant activity.


Cite this article:
Juna Thomas, Veeresh Babu. D, Anjan Kumar, Narayana Swamy V B. Studies on Anti-Depressant Activity of Perment-A Polyherbal Formulation in Experimental Animal Models. Research J. Pharmacology & Pharmacodynamics. 2016; 8(2): 45-54. doi: 10.5958/2321-5836.2016.00009.4


Recomonded Articles:

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, GC Bhuyna, BK Das, MM Rao.

DOI: 10.5958/2321-5836.2016.00008.2         Access: Open Access Read More

Author(s): Shameer Pasha, Mohamed Khaleel, Sukhen Som.

DOI: Not Available         Access: Open Access Read More

Author(s): Chunendra Kumar, Shiv Shankar Shukla, Ravindra Kumar Pandey

DOI: 10.5958/2321-5836.2017.00016.7         Access: Open Access Read More

Author(s): Aswani P. S., Kshirod Kumar Ratha, Dighe Dattatray Pandurang, M. M. Rao, Remya Vijayan

DOI: 10.5958/2321-5836.2018.00008.3         Access: Open Access Read More

Author(s): Jeevanagouda Patil, Kuppast I.J, Kishan Kumar M A, Kishan K G

DOI: 10.5958/2321-5836.2016.00032.X         Access: Open Access Read More

Author(s): Kishan K G, Shekshavali. T, Kuppast I.J, Kishan Kumar MA, Jeevanagouda Patil

DOI: 10.5958/2321-5836.2016.00030.6         Access: Open Access Read More

Author(s): M. Vanajakshi, J.H. Virupaksha, Shilpa Maria

DOI: 10.5958/2321-5836.2016.00033.1         Access: Open Access Read More

Author(s): Sudhanshu Kumar Meher, Banmali Das, Purnendu Panda, GC Bhuyan, MM Rao.

DOI: 10.5958/2321-5836.2016.00006.9         Access: Open Access Read More

Author(s): Nikhil P. Varghese, Shekshavali T. , Prathib B., I.J. Kuppast

DOI: 10.5958/2321-5836.2017.00007.6         Access: Open Access Read More

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, Das, GC Nanda.

DOI: Not Available         Access: Open Access Read More

Author(s): Banamali Das, Purnendu Panda, SK Meher, GC Bhuyan, DS Sahu, Bikartan Das, G Ch D Nagalakshmi, MM Rao.

DOI: 10.5958/2321-5836.2015.00010.5         Access: Open Access Read More

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, BK Das, MM Rao, GChD Naga Lakshmi.

DOI: 10.5958/2321-5836.2015.00011.7         Access: Open Access Read More

Author(s): T. Shekshavali, S. Roshan

DOI: 10.5958/2321-5836.2016.00031.8         Access: Open Access Read More

Author(s): Manasa K.S, Kuppast I.J, Kishan Kumar M.A , Akshara K

DOI: 10.5958/2321-5836.2016.00034.3         Access: Open Access Read More

Author(s): Lubna Azmi, Shyam Sundar Gupta, Ila Shukla, Padam Kant, O. P. Sidhu, Ch. V. Rao

DOI: 10.5958/2321-5836.2017.00001.5         Access: Open Access Read More

Author(s): Dipti Phadtare, Rajashri Kulkarni

DOI: 10.5958/2321-5836.2016.00016.1         Access: Open Access Read More

Author(s): Sudhanshu Kumar Meher, P K Mukherjee, S K Banarjee Chaudhury, Bani Marjit, B PShaw.

DOI: 10.5958/2321-5836.2016.00014.8         Access: Open Access Read More

Author(s): Nadiminti Satish Reddy, Vidyasabbani, B. Pravanthi, B. Vijaya Laxmi, B. Harika.

DOI: 10.5958/2321-5836.2016.00023.9         Access: Open Access Read More

Author(s): U. S. Jijith , C. R. Sudhakaran Nair, K. Pramod

DOI: 10.5958/2321-5836.2016.00001.X         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags