Author(s): Ganesh G. Dhakad, Megha S. Nannaware, Gauri V. Wagh, Abhijit V. Shrirao, N.I. Kochar, A.V. Chandewar

Email(s): ganeshdhakad552@gmail.com

DOI: 10.52711/2321-5836.2023.00012   

Address: Ganesh G. Dhakad, Megha S. Nannaware, Gauri V. Wagh, Abhijit V. Shrirao, N.I. Kochar, A.V. Chandewar
Pataldhamal Wadhwani College of Pharmacy, Yavatmal.
*Corresponding Author

Published In:   Volume - 15,      Issue - 2,     Year - 2023


ABSTRACT:
The pumpkin belongs to the family of Cucurbitaceae, is a well-known edible plant that has been frequently used as functional food or herbal medicine. Pumpkins contain rich unsaturated fatty acids, phytoestrogens and vitamins E in their seeds that have potential pharmaceutical, nutraceutical, and cosmeceutical properties. Information regarding their nutritional components and therapeutic properties of pumpkin seeds has expanded dynamically in the recent years and this review focus on the three main components of pumpkin seeds that described before. Several types of unsaturated fatty acids are the dominant component in pumpkin seeds which can play a role in the disease prevention and promote health. Pumpkin seeds also contain the important phytoestrogen compounds, i.e., secoisolariciresinol and lariciresinol that have estrogenic-like effect such as preventing hyperlipidemia and osteoporosis for menopausal women. Phytoestrogens in pumpkin seeds also could be related to a reduced hormone-dependent tumor. Pumpkin seeds are rich in vitamin E contents as an emerging free radical scavenger, anti-aging and antioxidant such as a-tocopherol and g-tocopherol. Findings of these studies prove that patents field for the innovation product of pumpkin seeds holds promise for the future along with their immense nutraceutical properties.


Cite this article:
Ganesh G. Dhakad, Megha S. Nannaware, Gauri V. Wagh, Abhijit V. Shrirao, N.I. Kochar, A.V. Chandewar. Review on medicinal Use of Pumpkin Seed on Human Health. Research Journal of Pharmacology and Pharmacodynamics.2023;15(2):59-5. doi: 10.52711/2321-5836.2023.00012

Cite(Electronic):
Ganesh G. Dhakad, Megha S. Nannaware, Gauri V. Wagh, Abhijit V. Shrirao, N.I. Kochar, A.V. Chandewar. Review on medicinal Use of Pumpkin Seed on Human Health. Research Journal of Pharmacology and Pharmacodynamics.2023;15(2):59-5. doi: 10.52711/2321-5836.2023.00012   Available on: https://rjppd.org/AbstractView.aspx?PID=2023-15-2-4


REFERENCE:
1.    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8681145/
2.    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4032845/
3.    Lee YK, WI Chung, H Ezura (2003) Efficient Plant Regeneration via Organogenesis in Winter Squash (Cucurbita maxima Duch). Plant Sciences 164 (3): 413-418
4.    Jia W, W Gao, L Tang (2003) Antidiabetic herbal drugs officially approved In China. Phytotherapy Research 17(10): 1127-1134.
5.    Adolfo AC, H Michael (2005) Mexican plants with hypoglycemic effect Used in the treatment of diabetes. Journal of Ethnopharmacology 99: 325-348.
6.    Yadav M, S Jain, R Tomar, GBKS Prasad, H Yadav (2010) Medicinal and Biological potential of pumpkin. Nutrition Research Review 23(2): 184-190.
7.    Seema Patel (2013) Pumpkin (Cucurbita sp) seeds as nutraceutic: a Review on status quo and Scopes. Mediterranean Journal of Nutrition Metabolism 6(3): 183-189.
8.    Naghii MR, M Mofid (2007) Impact of daily consumption of iron fortified Ready-to-eat cereal and pumpkin seed kernels (Cucurbita pepo) on Serum iron in adult women. Biofactors 30(1): 19-26.
9.    Ardabili, AG, R Farhoosh, M HH Khodaparast (2011) Chemical Composition and Physicochemical Properties of Pumpkin Seeds (Cucurbita pepo Subsp pepo Var Styriaka) Grown in Iran. Journal of Agriculture Sciences and Technology 13: 1053-1063.
10.    Ryan E, K Galvin, TP Connor, AR Maguire, NM Brien (2007) Phytosterol, Squalene, tocopherol content and fatty acid profile of selected seeds,
11.    9. Kim MY, EJ Kim, YN Kim, C Choi, BH Lee (2012) Comparison of the Chemical compositions and nutritive values of various pumpkin (Cucurbitaceae) species and parts. Nutrition Research Practices 6(1): 21-27.
12.    Andjelkovic M, J Van Camp, A Trawka, R Verhe (2010) Phenolic Compounds and some parameters of pumpkin seed oil. Euorpian Journal Of Lipid Science 112(2): 208-217.
13.    Nkosi CZ, AR Opoku, SE Terblanche (2006) Antioxidative effects of Pumpkin seed (Cucurbita pepo) protein isolate in CCl4- induced liver
14.    Injury in low-protein fed rats. Journal of Phytotherapy Research 20(11): 935-940.
15.    El Boghdady NA (2011) Protective effect of ellagic acid and pumpkin Seed oil against methotrexate-induced small intestine damage in rats. Indian Journal of Biochemistry and Biophysiology 48(6): 380-387.
16.    Ward D, P Ainsworth (1998) The development of a nutritious low cost Weaning food for Kenya infants. African Journal of Health Sciences 5(1-2): 89-95.
17.    Makni M, H Fetoui, NK Gargouri, M Garoui, H Jaber, et al. (2008) Hypolipidemic and hepatoprotective effects of flax and pumpkin seed Mixture rich in omega-3 and omega-6 fatty acids in hypercholesterolemic Rats. Food Chemistry Toxicology 46(12): 3714-3720.
18.    Gossell Williams M, C Hyde, T Hunter, D Simms Stewart, H Fletcher, et Al. (2011) Improvement in HDL cholesterol in postmenopausal women Supplemented with pumpkin seed oil: pilot study. Climacteric 14(5): 558-564.
19.    Barakat LA, RH Mahmoud (2011) The anti-atherogenic, renal protective And immunomodulatory effects of purslane, pumpkin and flax seeds on Hypercholesterolemic rats. North American Journal of Medical Sciences 3(9): 411-417.
20.    Hammer KA, CF Carson, TV Riley (1999) Antimicrobial activity of Essential oils and other plant extracts. Journal of Applied Microbiology 86(6): 985-990.
21.    Cheong NE, YO Choi, WY Kim, Bae IS, Cho MJ, et al. (1997) Purification And characterization of an antifungal PR-5 protein from pumpkin leaves. Journal of Molecular Cell 7(2): 214-219.
22.    18. Matus Z, Molna´r P and Szabo´ LG (1993) Main carotenoids inPressed seeds (Cucurbitae semen) of oil pumpkin (CucurbitaPepo convar. Pepo var. styriaca) (article in Hungarian). ActaPharm Hung 63, 247–256.
23.    Mansour EH, Dworschak E, Pollhamer Z, et al. (1999) Pumpkin and canola seed proteins and bread quality. ActaAlimentaria 28, 59–70.
24.    Glew RH, Glew RS, Chuang LT, et al. (2006) Amino acid, Mineral and fatty acid content of pumpkin seeds (CucurbitaSpp) and Cyperus esculentus nuts in the Republic of Niger.Plant Foods Hum Nutr 61, 51–56.
25.    Nwokolo E and Sim JS (1987) Nutritional assessment of Defatted oil meals of melon (Colocynthis citrullus) and flutedPumpkin (Telfairia occidentalis) by chick assay. J Sci FoodAgric 38, 237–246.
26.    Koike K, Li W, Liu L, et al. (2005) New phenolic glycosidesFrom the seeds of Cucurbita moschata. Chem Pharm Bull 53,225–228.
27.    Jun HI, Lee CH, Song GS, et al. (2006) Characterization of The pectic polysaccharides from pumpkin peel. Food Sci Tech39, 554–561.
28.    Xiong XM (2000) Study on extraction and separation of Effective composition of pumpkin polysaccharide and its Glucatonic effect. Chin Tradit Patent Med 22, 563–565.
29.    Vassiliou AG, Neumann GM, Condron R, et al. (1998)Purification and mass spectrometry-assisted sequencing of Basic antifungal proteins from seeds of pumpkin (Cucurbita Maxima). Plant Sci 134, 141–162.
30.    Xia T and Wang Q (2007) Hypoglycaemic role of CucurbitaFicifolia (Cucurbitaceae) fruit extract in streptozotocin-Induced diabetic rats. J Sci Food Agric 87, 1753–1757.
31.    Kwon YI, Apostolidis E, Kim YC, et al. (2007) HealthBenefits of traditional corn, beans, and pumpkin: in vitro Studies for hyperglycemia and hypertension management. J Med Food 10, 266–275.
32.    Acosta-Patin˜o JL, Jime´nez-Balderas E, Jua´rez-Oropeza MA, Et al. (2001) Hypoglycemic action of Cucurbita ficifoliaOn type 2 diabetic patients with moderately high bloodGlucose levels. J Ethnopharmacol 77, 99–101.
33.    Andrade-Cetto A and Heinrich M (2005) Mexican plantsWith hypoglycaemic effect used in the treatment of diabetes. J Ethnopharmacol 99, 325–348.
34.    Nkosi CZ, Opoku AR and Terblanche SE (2005) Effect ofPumpkin seed (Cucurbita pepo) protein isolate on the activityLevels of certain plasma enzymes in CCl4-induced liver injuryIn low-protein fed rats. Phytother Res 19, 341–345.
35.    Wang P (1999) Experimental study on pharmacologicalActions about analgesia, anti-inflammation of CucurbitaMoschata Duch. Shizhen Med Mteria Med Res 19, 567–569.
36.    Krishnamoorthi R, Gong YX and Richardson M (1999) A newProtein inhibitor of trypsin and activated Hageman ffacto from pumpkin (Cucurbita maxima) seeds. FEBS Lett 273,163–167.
37.    Dannenhoffer JM, Suhr RC and Thompson GA (2001) Phloem-specific expression of the pumpkin fruit trypsinInhibitor. Planta 212, 155–162.
38.    Herna´ndez-Ramı´rez BD and Guerra-Modernell MJ (1997) Development and evaluation of a dietetic formula made of Pumpkin, rice, chicken and vegetable oils for children with Diarrhea (article in Spanish). Arch Latinoam Nutr 47, 57–61.  Ito Y, Maeda S and Sugiyama T (1986) Suppression of 7, 12-dimethylbenz [a]anthracene-induced chromosome Aberrations in rat bone marrow cells by vegetable juices. Mutat Res 172, 55–60.
39.    De Escalada Pla MF, Ponce NM, Wider ME, et al. (2005) Chemical and biochemical changes of pumpkin (CCucurbit Moschata Duch) tissue in relation to osmotic stress. J Sci Food Agric 85, 1852–1860.

Recomonded Articles:

Author(s): Sudhanshu Kumar Meher, Purnendu Panda, Banmali Das, G. C. Bhuyan, Dr. K. K. Rath

DOI: 10.5958/2321-5836.2018.00023.X         Access: Open Access Read More

Author(s): Sachin Aglawe, Amol Gayke, Kavita Sharma, Sonali Jadhav, Sanjivani Gore, Bhagyashri Pandit, Sonali Valate, Mayuri Wagh

DOI: 10.5958/2321-5836.2020.00003.8         Access: Open Access Read More

Author(s): Sanjib Kumar Das, Anuradha Das, Banamali Das, Purnendu Panda, G. C. Bhuyan, Bipin Bihari Khuntia

DOI: 10.5958/2321-5836.2017.00036.2         Access: Open Access Read More

Author(s): Satish Narra, Bandenawaz Ramadurg, Saraswathi C D.

DOI: Not Available         Access: Open Access Read More

Author(s): Suneel Kumar A, Venkatarathanamma. V, Naga Saibabu V, Nageswara Rao Tentu, Pavan Kumar Kota, K. Suneel Kumar, A. Vijayalakshmi

DOI: 10.5958/2321-5836.2017.00009.X         Access: Open Access Read More

Author(s): Rohit J. Bhor, Harshala Damdhar, Geeta Kokate, Maduri Salve, Swati Andhale

DOI: 10.5958/2321-5836.2016.00025.2         Access: Open Access Read More

Author(s): Serene Adak, Dipesh Chakraborty, Himangshu S. Maji, Satakshi Basu, Pradip Roy, Sutanuka Mitra, Nabanita Mukherjee, Samarendra Barik, Arunava Goswami

DOI: 10.5958/2321-5836.2018.00009.5         Access: Open Access Read More

Author(s): Jeena S, Venkateswaramurthy N, Sambathkumar R

DOI: 10.5958/2321-5836.2020.00004.X         Access: Open Access Read More

Author(s): Rohit Gundamaraju Diana Vivian Atigari, DS Helen Sheeba, Ramesh C.

DOI: Not Available         Access: Open Access Read More

Author(s): Gharge Deepali, Bavaskar Sunil, Todkar Pavan,Dhabale Pandurang.

DOI: Not Available         Access: Open Access Read More

Author(s): Mamillapalli Vani, Mannem Vijaya Sai Sri, Padma Latha Khantamneni

DOI: 10.5958/2321-5836.2018.00014.9         Access: Open Access Read More

Author(s): Banashree Jena, G.C. Nanda, Bipin Bihari Khuntia

DOI: 10.5958/2321-5836.2018.00030.7         Access: Open Access Read More

Author(s): K. B. Mahapatra, A. K. Das, Manjusri Sahoo

DOI: 10.5958/2321-5836.2018.00021.6         Access: Open Access Read More

Author(s): Shivakumar SI, Amreen Begum, Syeda Sana, Ansari Firdous

DOI: Not Available         Access: Open Access Read More

Author(s): Manasi Nabar, Swati Patil.

DOI: Not Available         Access: Open Access Read More

Author(s): Patil SM, Sapkale GN, Kumbhar PB, Maske AP.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags