Author(s): N B Sridharamurthy, R Yogananda.

Email(s): murthy.sridhara@yahoo.com

DOI: Not Available

Address: N. B. Sridharamurthy1* and R. Yogananda2
1Department of Pharmacology, Dayanandsagar College of Pharmacy, Bangalore, India
2Department of Pharmaceutics, SJM college of Pharmacy, Chitradurga, India
*Corresponding Author

Published In:   Volume - 2,      Issue - 6,     Year - 2010


ABSTRACT:
The main objective of this study is to evaluate the antibacterial and antioxidant activity of ethanol extract of Xanthium strumarium L. Disc diffusion and broth serial dilution tests were used to determine the antibacterial activity of the ethanol extract on two Gram-positive strains (Bacillus subtilus NCIM 2718, Staphylococcus aureus ATCC25923) and three Gram-negative bacterial strains (Pseudomonas aeruginosa ATCC 27853, Klebsiella pneumoniea ATCC 70063 and Eschrichia coli ATCC 25922). The ethanol extract of the root of plant was subjected to preliminary phytochemical analysis. Free radical scavenging activity of the ethanol extract at different concentration was determined with 1, 1-diphenyl-2 picrylhydrazyl (DPPH), superoxide free radical free radical scavenging activity and lipid peroxide inhibition activity. Ethanol extract showed inhibition in all the organisms under test. The result from the present study shows that the ethanol extract of X. strumarium has antibacterial activity. The antibacterial activity may be attributed to the presence of tannins, flavonoids and triterpinoids and phenolic acids in the ethanol extract. The antibacterial and antioxidant activity exhibited by the ethanol extract can be corroborated to the usage of this plant in Indian folk medicine.


Cite this article:
N B Sridharamurthy, R Yogananda. Antioxidant and antibacterial activity of Xanthuim strumarium L. Research J. Pharmacology and Pharmacodynamics. 2010; 2(6): 407-413.


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