Research Journal of Pharmacology and Pharmacodynamics

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2321-5836 (Online)
0975-4407 (Print)


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In vitro Anti-Alzheimer and Anti Oxidant activity of the Peels of Citrus maxima fruits

Author(s): P Vijayalakshmi, R Radha.

Email(s): vijayapharma7@gmail.com

DOI: 10.5958/2321-5836.2016.00005.7   

Address: P. Vijayalakshmi*, R. Radha
Department of Pharmacognosy, College of Pharmacy, Madras Medical College, Chennai – 600003
*Correspondin Author

Published In:   Volume - 8,      Issue - 1,     Year - 2016

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ABSTRACT:
Alzheimer’s disease is an age-associated, irreversible, progressive neurodegenerative disease which is characterized by severe memory loss, unusual behavior, personality changes, and a decline in cognitive function. Even today Alzheimer disease is spreading in very fast pace though large number of researchers and manufacturers are engaged to find effective medication but result is not satisfactory. Most of the drugs or medicines have high tendency of side effect. This fact made me inclined towards plants to execute the research work. Normally it is observed that side effects in plant derivative are very less. Most potential target for the treatment and slowing down of Alzheimer disease progression is cholinesterase inhibitors from plants. The anti oxidant and anti cholinesterase activity of various extracts of Citrus maxima fruit peels were studied by DPPH assay and Hydrogen Peroxide radical scavenging effect for in vitro analysis; Whereas Ellman’s colorimetric methods were used for anti cholinesterase activity estimation. Ethanolic extract shown the potent anti oxidant (DPPH; IC50= 25 µg/ml , HPSA; IC50= 54 µg/ml ) and anti cholinesterase activity with IC50 value of 115µg/ml. These plants were found to be potent enough to be studied further for its in vivo Anti Alzheimer disease and to perform formulations.


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Cite this article:
P Vijayalakshmi, R Radha. In vitro Anti-Alzheimer and Anti Oxidant activity of the Peels of Citrus maxima fruits. Research Journal of Pharmacology and Pharmacodynamics. 2016; 8(1): January -March, 17-22. doi: 10.5958/2321-5836.2016.00005.7

Cite(Electronic):
P Vijayalakshmi, R Radha. In vitro Anti-Alzheimer and Anti Oxidant activity of the Peels of Citrus maxima fruits. Research Journal of Pharmacology and Pharmacodynamics. 2016; 8(1): January -March, 17-22. doi: 10.5958/2321-5836.2016.00005.7   Available on: https://rjppd.org/AbstractView.aspx?PID=2016-8-1-5


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Research Journal of Pharmacology and Pharmacodynamics (RJPPD) (ISSN: print-0975-4407, online- 2321-5836) is an international, peer-reviewed journal, devoted to Pharmacology, Pharmacodynamics and Medical Sciences. The aim of RJPPD is to increase the impact of pharmacological research both in academia and industry, with strong emphasis on quality and originality. RJPPD publishes Original research Articles, Short Communications, Review Articles in all areas of pharmacology, pharmacokinetics and human physiology.

The journal is published quaterly every year in last week of March, June, September and December (i.e. 4 issues in each calendar year).    
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