Author(s): Saudagar RB, Buchake VV, Bachhav RS.

Email(s): bachhavrss@gmail.com

DOI: Not Available

Address: Saudagar R.B., Buchake V.V. and *Bachhav R.S.
KCT’s Ravindra Gambhirrao Sapkal College of Pharmacy. Anjaneri, Nashik-13
*Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2012


ABSTRACT:
Alzheimers disease very basically is characterized by the loss of the cognitive functions.ß-amyloid is a major histopathological hallmark of Alzheimer’s disease (AD).The disease is characterized by extracellular neuritic plaque composed of fibrillar-amyloid peptide and intracellular neurofibrillary tangles containing hyperphosphorylated tau. The peptides are generated by successive proteolysis of beta amyloid precursor protein, a large transmembrane glycoprotein that is initially cleaved by the site amyloid precursor protein cleaving enzyme -1 and subsequently by gamma secretase in the transmembrane domain. Retinoic acid is active metabolite of Vitamin A. Deprivation of Vitamin A results in amyloid-ß accumulation, loss of hippocampal long term potentiation and memory deficit, all of which are hall mark of Alzheimers disease. Here we focused a role of retinoic acid on different pathophysiological features of Alzheimers disease. Retinoic acid may play an active role in treating neurodegenerative disorder. Retinoids appear to normalize many pathological states, and clinical side effects presently reported are mostly not serious except for retinoic acid syndrome


Cite this article:
Saudagar RB, Buchake VV, Bachhav RS. Role of Retinoids in treatment of Alzheimer’s disease. Research J. Pharmacology and Pharmacodynamics. 2012; 4(3): 144-149 .

Cite(Electronic):
Saudagar RB, Buchake VV, Bachhav RS. Role of Retinoids in treatment of Alzheimer’s disease. Research J. Pharmacology and Pharmacodynamics. 2012; 4(3): 144-149 .   Available on: https://rjppd.org/AbstractView.aspx?PID=2012-4-3-14


Recomonded Articles:

Author(s): Dipsundar Sahu, Shakti Bhushan, Debajyoti Das, Saroj Kumar Debnath, Laxmidhar Barik, Vandana Meena, Vikas Singh, Amit Kumar Dixit, PVV Prasad

DOI: 10.52711/2321-5836.2021.00015         Access: Open Access Read More

Author(s): Sudhanshu Kumar Meher, P K Mukherjee, S K Banarjee Chaudhury, Bani Marjit, B PShaw.

DOI: 10.5958/2321-5836.2016.00014.8         Access: Open Access Read More

Author(s): Jayanth P. C. , Prasanna Kumar Kar, M. Niranjan Babu

DOI: 10.5958/2321-5836.2016.00020.3         Access: Open Access Read More

Author(s): Akanksha Pandey, Nikita Saraswat, Pranay Wal, Rashmi Saxena Pal, Ankita Wal, Deepa Maurya

DOI: 10.5958/2321-5836.2019.00029.6         Access: Open Access Read More

Author(s): Nadiminti Satish Reddy, Vidyasabbani, B. Pravanthi, B. Vijaya Laxmi, B. Harika.

DOI: 10.5958/2321-5836.2016.00023.9         Access: Open Access Read More

Author(s): Yogesh Shivhare, Priya Singh ,UK Patil.

DOI: Not Available         Access: Open Access Read More

Author(s): Sudhakar P, Poorana Pushkalai S, Sabarinath C, Priyadharshini S, Haripriya S

DOI: 10.5958/2321-5836.2018.00002.2         Access: Open Access Read More

Author(s): G. Sarvan Kumar, S. Swathi, B. Laxmi Prasanna, M. Prathima Kumari, R. Suthakaran

DOI: 10.5958/2321-5836.2019.00012.0         Access: Open Access Read More

Author(s): Jhakeshwar Prasad, Ashish Kumar Netam, Ritika Singh, Manisha Sahu, Trilochan Satapathy, S. Prakash Rao, Purnima Baghel, Mahendra Kumar Sahu

DOI: 10.5958/2321-5836.2019.00009.0         Access: Open Access Read More

Author(s): Ashish Kumar Netam, Jhakeshwar Prasad, Trilochan Satapathy

DOI: 10.5958/2321-5836.2019.00008.9         Access: Open Access Read More

Author(s): B Sangamewaran, Manmeet Singh Saluja, Ajay Sharma, Chetan Dubey.

DOI: Not Available         Access: Open Access Read More

Author(s): Chirag K Patel, B Panigrahi , R Badmanaban, CN Patel.

DOI: Not Available         Access: Open Access Read More

Author(s): Aathira Menon, Apthadevi, Roshni P R

DOI: 10.5958/2321-5836.2019.00021.1         Access: Open Access Read More

Author(s): R Sathish, K Natarajan, S Selvakumar.

DOI: Not Available         Access: Open Access Read More

Author(s): Pushpendra K Patel, Jyoti Sahu, Narendra K Prajapati, BK Dubey, A Alia.

DOI: Not Available         Access: Open Access Read More

Author(s): Saiprasanna Behera, S. Manohar Babu, Y Roja Ramani, Prasanta Kumar Choudhury, Rajeshree Panigrahi.

DOI: Not Available         Access: Open Access Read More

Author(s): Ajay Kshirsagar, Deepa Ingawale, Purnima Ashok, Vrushali Thorve, Tanmay Dodal, Anurag Dodal, Mahesh Kahane, Bharat Zope.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 

Journal Policies & Information




Recent Articles




Tags