Research Journal of Pharmacology and Pharmacodynamics

ISSN

2321-5836 (Online)
0975-4407 (Print)


Submit Article

Role of Retinoids in treatment of Alzheimer’s disease

Author(s): Saudagar RB, Buchake VV, Bachhav RS.

Email(s): bachhavrss@gmail.com

DOI: Not Available

Address: Saudagar R.B., Buchake V.V. and *Bachhav R.S.
KCT’s Ravindra Gambhirrao Sapkal College of Pharmacy. Anjaneri, Nashik-13
*Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2012

 View HTML        View PDF

ABSTRACT:
Alzheimers disease very basically is characterized by the loss of the cognitive functions.ß-amyloid is a major histopathological hallmark of Alzheimer’s disease (AD).The disease is characterized by extracellular neuritic plaque composed of fibrillar-amyloid peptide and intracellular neurofibrillary tangles containing hyperphosphorylated tau. The peptides are generated by successive proteolysis of beta amyloid precursor protein, a large transmembrane glycoprotein that is initially cleaved by the site amyloid precursor protein cleaving enzyme -1 and subsequently by gamma secretase in the transmembrane domain. Retinoic acid is active metabolite of Vitamin A. Deprivation of Vitamin A results in amyloid-ß accumulation, loss of hippocampal long term potentiation and memory deficit, all of which are hall mark of Alzheimers disease. Here we focused a role of retinoic acid on different pathophysiological features of Alzheimers disease. Retinoic acid may play an active role in treating neurodegenerative disorder. Retinoids appear to normalize many pathological states, and clinical side effects presently reported are mostly not serious except for retinoic acid syndrome


Keywords:

Cite this article:
Saudagar RB, Buchake VV, Bachhav RS. Role of Retinoids in treatment of Alzheimer’s disease. Research J. Pharmacology and Pharmacodynamics. 2012; 4(3): 144-149 .


Recomonded Articles:

Experimental studies on the Renal Protective effect of Gokshura (Tribulus terrestris Linn) and Varuna (Crataeva nurvala Buch-Ham)

Author(s): Sudhanshu Kumar Meher, P K Mukherjee, S K Banarjee Chaudhury, Bani Marjit, B PShaw.

DOI: 10.5958/2321-5836.2016.00014.8         Access: Open Access Read More

Evaluation of Antidiabetic Activity of Rumex vesicarius in Streptozotocin Induced Diabetic Albino Rats

Author(s): Nadiminti Satish Reddy, Vidyasabbani, B. Pravanthi, B. Vijaya Laxmi, B. Harika.

DOI: 10.5958/2321-5836.2016.00023.9         Access: Open Access Read More

Evaluation of hepatoprotective and invitro cytotoxic activity of leaves of Chrozophora plicata Linn

Author(s): Kadiri Sunil Kumar, Avanapu Srinivasa Rao

DOI: 10.5958/2321-5836.2017.00004.0         Access: Open Access Read More

In vitro Anti-Alzheimer and Anti Oxidant activity of the Peels of Citrus maxima fruits

Author(s): P Vijayalakshmi, R Radha.

DOI: 10.5958/2321-5836.2016.00005.7         Access: Open Access Read More

Evaluation of Nootropic activity Potential of Krill Oil in Diazepam Induced Amnesic Mice

Author(s): Jayanth P. C. , Prasanna Kumar Kar, M. Niranjan Babu

DOI: 10.5958/2321-5836.2016.00020.3         Access: Open Access Read More

Healing Potential of Trichosanthes dioica Roxb on Burn Wounds

Author(s): Yogesh Shivhare, Priya Singh ,UK Patil.

DOI: Not Available         Access: Open Access Read More

Molecular docking and synthesis of 1, 2, 4 - triazin analogue of diclofenac as potential ligand for parkinson’s

Author(s): Sudhakar P, Poorana Pushkalai S, Sabarinath C, Priyadharshini S, Haripriya S

DOI: 10.5958/2321-5836.2018.00002.2         Access: Open Access Read More

Evaluation of Hepatoprotective and Antioxidant Activity of Classical Ayurvedic Formulation Punarnavashtak Kwath Against Paracetamol Induced Hepatotoxicity in Rats

Author(s): VN Shah, DB Doshi, MB Shah , PA Bhatt.

DOI: Not Available         Access: Open Access Read More

Evaluation of Wound Healing, Anti-Inflammatory and Antioxidant Activity of Rhizomes of Curcuma longa

Author(s): Rita M Charde, Hemant J Dhongade, Manoj S Charde, Siddheshwar B Joshi.

DOI: Not Available         Access: Open Access Read More

Role of Retinoids in treatment of Alzheimer’s disease

Author(s): Saudagar RB, Buchake VV, Bachhav RS.

DOI: Not Available         Access: Open Access Read More

Evaluation of Effect of Rotenone on C6 Glial Cells by Comet Assay

Author(s): B Sangamewaran, Manmeet Singh Saluja, Ajay Sharma, Chetan Dubey.

DOI: Not Available         Access: Open Access Read More

Cardioprotective Activity of Ocimum canum Hydro-alcoholic Leaf Extracts Against Isoproterenol Induced Myocardial Infarction in Rats

Author(s): Saiprasanna Behera, S. Manohar Babu, Y Roja Ramani, Prasanta Kumar Choudhury, Rajeshree Panigrahi.

DOI: Not Available         Access: Open Access Read More

Biochemical Origins of Alzheimer’s Disease with Treatment Techniques

Author(s): Chirag K Patel, B Panigrahi , R Badmanaban, CN Patel.

DOI: Not Available         Access: Open Access Read More

Antidiabetic Activity of Swietenia mahagoni Seed Powder in Alloxan Induced Diabetic Mice

Author(s): R Sathish, K Natarajan, S Selvakumar.

DOI: Not Available         Access: Open Access Read More

A Review on Ethnopharmacological approaches to Wound Healing and Curative Progression

Author(s): Ashish Kumar Netam, Jhakeshwar Prasad, Trilochan Satapathy

DOI: 10.5958/2321-5836.2019.00008.9         Access: Closed Access Read More

Evaluation of Gastroprotective Influence of Vitamin C, Melatonin, Rabeprazole and their Combination in Ethanol Induced Ulcer Model

Author(s): Nitin Mahurkar, Sayeed Ul hasan SM, Arati Malpani A, Chetan Manjunath.

DOI: Not Available         Access: Open Access Read More

Hepatoprotective and Antioxidant Potential of Calotropis gigantea in Cyclosporine–An Induced Hepatotoxicity

Author(s): Ajay Kshirsagar, Deepa Ingawale, Purnima Ashok, Vrushali Thorve, Tanmay Dodal, Anurag Dodal, Mahesh Kahane, Bharat Zope.

DOI: Not Available         Access: Open Access Read More

Biochemical Estimation of High Dose of Omeprazole in Experimental Rodents.

Author(s): G. Sarvan Kumar, S. Swathi, B. Laxmi Prasanna, M. Prathima Kumari, R. Suthakaran

DOI: 10.5958/2321-5836.2019.00012.0         Access: Closed Access Read More

Therapeutic Approaches for the Management of Parkinson’s Disease

Author(s): Jhakeshwar Prasad, Ashish Kumar Netam, Ritika Singh, Manisha Sahu, Trilochan Satapathy, S. Prakash Rao, Purnima Baghel, Mahendra Kumar Sahu

DOI: 10.5958/2321-5836.2019.00009.0         Access: Closed Access Read More

Hepatoprotective activity of chenopodium album Linn. in carbon tetrachloride induced hepatotoxicity rats

Author(s): Gauri Karwani , Siddhraj S Sisodia.

DOI: 10.5958/2321-5836.2015.00007.5         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 

Quick Links

Latest Issues

Popular Articles


Recent Articles



Ayurvedic Management of Kampavata (Parkinson’s Disease) – A Case Study Report
Indolizine: In-Silico Identification of Inhibitors against Mutated BCR-ABL Protein of Chronic Myeloid Leukemia.
Study on Analysing of Risk Factors and Prevalance of Urolithiasis in the Tertiary Hospitals of Erode, Tamil Nadu
Plasma Therapy types, adverse effect and for some Critical Disease
The Exploring of Current Development status and the unusual Symptoms of Coronavirus Pandemic (Covid-19)
Detection of Arthritis by Erythrocyte Sedimentation Rate (ESR) Test – A Review
A Systematic Review of the Incidence, Prevalence Work Limitations of Osteoarthritis, Rheumatoid Arthritis, Back Pain, Multiple Sclerosis
A Valuable insight to the novel deadly COVID-19: A Review
Significance of Identification of Ayurvedic Drugs with its Different Sources
Overview of Neutraceuticals
A Review article on “Concept of the five ‘A’s in the treatment of Cardiac Arrhythmia”
Review on Modern Drug Discovery Process
Indian Species and their Medicinal Property
Single Cell Protein Spirulina-A Nutrient Treasure
Retrospective Analytical Case Series Study on the Acid Peptic Disorders treated with Homoeopathic Medications
Anonychia Congenita: A Rare Disease
Management of Injuries during Outdoor Sports
Novel Coronavirus
Theoretical Study and treatment of Novel COVID-19
Review on Progeria: A Rare Genetic Premature Aging Disorder

Tags


About Journal

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) (ISSN: print-0975-4407, online- 2321-5836) is an international, peer-reviewed journal, devoted to Pharmacology, Pharmacodynamics and Medical Sciences. The aim of RJPPD is to increase the impact of pharmacological research both in academia and industry, with strong emphasis on quality and originality. RJPPD publishes Original research Articles, Short Communications, Review Articles in all areas of pharmacology, pharmacokinetics and human physiology.

The journal is published quaterly every year in last week of March, June, September and December (i.e. 4 issues in each calendar year).    
Read More  

Visitors

Today: 201
Yesterday: 195
Total: 329812