Research Journal of Pharmacology and Pharmacodynamics

ISSN

2321-5836 (Online)
0975-4407 (Print)


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Role of Retinoids in treatment of Alzheimer’s disease

Author(s): Saudagar RB, Buchake VV, Bachhav RS.

Email(s): bachhavrss@gmail.com

DOI: Not Available

Address: Saudagar R.B., Buchake V.V. and *Bachhav R.S.
KCT’s Ravindra Gambhirrao Sapkal College of Pharmacy. Anjaneri, Nashik-13
*Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2012

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ABSTRACT:
Alzheimers disease very basically is characterized by the loss of the cognitive functions.ß-amyloid is a major histopathological hallmark of Alzheimer’s disease (AD).The disease is characterized by extracellular neuritic plaque composed of fibrillar-amyloid peptide and intracellular neurofibrillary tangles containing hyperphosphorylated tau. The peptides are generated by successive proteolysis of beta amyloid precursor protein, a large transmembrane glycoprotein that is initially cleaved by the site amyloid precursor protein cleaving enzyme -1 and subsequently by gamma secretase in the transmembrane domain. Retinoic acid is active metabolite of Vitamin A. Deprivation of Vitamin A results in amyloid-ß accumulation, loss of hippocampal long term potentiation and memory deficit, all of which are hall mark of Alzheimers disease. Here we focused a role of retinoic acid on different pathophysiological features of Alzheimers disease. Retinoic acid may play an active role in treating neurodegenerative disorder. Retinoids appear to normalize many pathological states, and clinical side effects presently reported are mostly not serious except for retinoic acid syndrome


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Cite this article:
Saudagar RB, Buchake VV, Bachhav RS. Role of Retinoids in treatment of Alzheimer’s disease. Research J. Pharmacology and Pharmacodynamics. 2012; 4(3): 144-149 .


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Research Journal of Pharmacology and Pharmacodynamics (RJPPD) (ISSN: print-0975-4407, online- 2321-5836) is an international, peer-reviewed journal, devoted to Pharmacology, Pharmacodynamics and Medical Sciences. The aim of RJPPD is to increase the impact of pharmacological research both in academia and industry, with strong emphasis on quality and originality. RJPPD publishes Original research Articles, Short Communications, Review Articles in all areas of pharmacology, pharmacokinetics and human physiology.

The journal is published quaterly every year in last week of March, June, September and December (i.e. 4 issues in each calendar year).    
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