MM Ghaisas, Surbhi Sharma, GP Ganu, RP Limaye.
MM Ghaisas1*, Surbhi Sharma2, GP Ganu2 and RP Limaye3
1Indira College of Pharmacy, Tathwade, Pune 411 033
2Padmashree Dr. D.Y. Patil Institute of Pharmaceutical Sciences and Research, Dept. of Pharmacology, Pimpri, Pune-18 (Maharashtra), India.
3BVDU Medical College and Hospital, Sangli.
Volume - 2,
Issue - 1,
Year - 2010
In the present study, the antiulcer activity of hydroalcoholic extract of roots of Colebrookea oppositifolia Sm. (CO) was evaluated in ethanol and swim stress induced peptic ulcer models. In both the models, various parameters like ulcer index, percentage protection, gastric wall mucus, catalase, reduced glutathione (GSH), lipid peroxidation (LPO) and superoxide dismutase (SOD) were estimated. CO significantly reduced the ulcer index and increased the gastric wall mucus in both the models. CO showed significant antioxidant activity as indicated by significant decrease in LPO and increase in catalase, GSH and SOD levels in stomach tissue homogenate. The results suggest that hydroalcoholic extract of roots of Colebrookea oppositifolia possess antiulcer activity due to its muco-protective action and antioxidant potential.
Cite this article:
MM Ghaisas, Surbhi Sharma, GP Ganu, RP Limaye. Antiulcer Activity of Colebrookea oppositifolia Sm. Research J. Pharmacology and Pharmacodynamics. 2010; 2(1):66-70.