Author(s): Jiban Debnath, Santosh B Dighe, Nachiket S Dighe, Mana Supriya

Email(s): sbdigheprcop@gmail.com

DOI: Not Available

Address: Jiban Debnath1, Santosh B. Dighe2*, Nachiket S. Dighe3 and Mana Supriya4
1Department of Pharmacology, Girijananda Chowdhury Institute of Pharmaceutical Science, Azara, Guwahati, Assam, (India)
2Department of Pharmacology, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, (India)
3Department of Medicinal Chemistry, Pravara Rural College of Pharmacy, Pravaranagar, Maharashtra, (India)
4Department of Pharmacology, NSHM, College of Pharmaceutical Technology, Kolkata. (India)
*Corresponding Author

Published In:   Volume - 3,      Issue - 1,     Year - 2011


ABSTRACT:
In present study the anticonvulsant activity of ethanolic extract of Holarrhena antidysenterica was carried out in swiss albino mice. The anticonvulsant activity of ethanolic extract of seeds of Holarrhena antidysenterica (250 and 500 mg/kg, p.o.) in mice was assessed by using maximum electroshock seizure (MES) test, pentylenetetrazol (PTZ), and bicuculine (BC) test. The ethanolic extract of H. antidysenterica significantly reduced the duration of seizures induced by maximal electroshock (MES). The ethanol extract in doses of 250 and 500 mg/kg conferred protection (17 and 50%, respectively) on the mice. The same doses also protected animals from tonic seizures induced by Pentylenetetrazol and significantly delayed the onset of tonic seizures produced by Pentylenetetrazol. The extract had no effect on bicuculine induced seizure. The ethanolic extract of H. antidysenterica (EEHA) reduced MES, PTZ induced convulsions.


Cite this article:
Jiban Debnath, Santosh B Dighe, Nachiket S Dighe, Mana Supriya. An Experimental Evaluation of Anticonvulsant Activity of Ethanolic Extract of Seeds of Holarrhena antidysenterica In Mice. Research J. Pharmacology and Pharmacodynamics. 2011; 3(1): 31-33.


Recomonded Articles:

Author(s): Jeevanagouda Patil, Kuppast I.J, Kishan Kumar M A, Kishan K G

DOI: 10.5958/2321-5836.2016.00032.X         Access: Open Access Read More

Author(s): M. Vanajakshi, J.H. Virupaksha, Shilpa Maria

DOI: 10.5958/2321-5836.2016.00033.1         Access: Open Access Read More

Author(s): Nikhil P. Varghese, Shekshavali T. , Prathib B., I.J. Kuppast

DOI: 10.5958/2321-5836.2017.00007.6         Access: Open Access Read More

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, Das, GC Nanda.

DOI: Not Available         Access: Open Access Read More

Author(s): M Lavanya, Asish Bhaumik, A Gopi Reddy, Ch Manasa, B Kalyani, S Sushmitha

DOI: 10.5958/2321-5836.2016.00012.4         Access: Open Access Read More

Author(s): Juna Thomas, Veeresh Babu D, Anjan Kumar, Narayana Swamy V B.

DOI: 10.5958/2321-5836.2016.00009.4         Access: Open Access Read More

Author(s): D. Benito Johnson, Faisal N.V, Rashid. K, Mohammed Haleel, V. Venkatanarayanan

DOI: 10.5958/2321-5836.2016.00018.5         Access: Open Access Read More

Author(s): Parveen Ranga, Amita Sharma

DOI: 10.5958/2321-5836.2017.00032.5         Access: Open Access Read More

Author(s): Jadhav Anil G, Narkhede Sachin B, Patil Mrutyunjay B, Vidyasagar G.

DOI: Not Available         Access: Open Access Read More

Author(s): Singh UR, Sutrakar SK, PC Kol, Sunil Rao, Ravishanker Shrivastava..

DOI: Not Available         Access: Open Access Read More

Author(s): Sathyaseelan Thennarasan, Subbiah Murugesan, Vajiravelu Sivamurugan

DOI: 10.5958/2321-5836.2017.00011.8         Access: Open Access Read More

Author(s): Olukayode Olugbenga Orole, Gerard O. Uyi, Ayofemi F. Gbadeyan

DOI: 10.5958/2321-5836.2016.00027.6         Access: Open Access Read More

Author(s): Mahendra Kumar Sahu, Trilochan Satapathy, Ashish Kumar Netam, Jhakeshwar Prasad

DOI: 10.5958/2321-5836.2018.00007.1         Access: Open Access Read More

Author(s): Gharge Deepali, Bavaskar Sunil, Todkar Pavan,Dhabale Pandurang.

DOI: Not Available         Access: Open Access Read More

Author(s): Rohit R. Patil, Mayur A. Chaudhari, Tushar A. Deshmukh

DOI: 10.5958/2321-5836.2018.00016.2         Access: Open Access Read More

Author(s): IJ Kuppast, P Vasudeva Nayak, MC Ravi, SS Biradar.

DOI: Not Available         Access: Open Access Read More

Author(s): Naiya Devgan, Meenakshi Barsaul, Rashmi Sindhwani, Smiti Nanda , Manish Devgan.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags