Research Journal of Pharmacology and Pharmacodynamics

ISSN

2321-5836 (Online)
0975-4407 (Print)


Submit Article

Pharmacodynamic influence of vitamin C and Esomeprazole on gastro protection in pylorus ligation and aspirin induced ulcers in rats

Author(s): Nitin M, Mohan Reddy U, Sayeed Ul Hasan SM.

Email(s): allnitin@yahoo.co.in

DOI: Not Available

Address: Nitin M.* , Mohan Reddy U. , Sayeed Ul Hasan S.M.
H.K.E.S’s, Matoshree Taradevi Rampure Institute of Pharmaceutical Sciences, Sedam Road, Gulbarga- 585 105, Karnataka.
*Corresponding Author

Published In:   Volume - 4,      Issue - 3,     Year - 2012

 View HTML        View PDF

ABSTRACT:
Gastric ulcer is one of the most prevalent gastrointestinal disorders, which affects approximately 5-10% of people during their life. The present study was aimed to find out the pharmacodynamic influence of Vitamin C and Esomeprazole and their combination on Gastro intestinal parameters in pylorus ligation and aspirin induced ulcers in rats. In pylorus ligation induced ulcer model, various parameters were studied viz. gastric volume, pH, total acidity, free acidity, and ulcer index. Ulcer index and percentage inhibition of ulceration was determined for aspirin induced ulcer model. The antiulcer effect of the combination of vitamin C 4.5 mg/200 g and esomeprazole 0.54 mg/200 g b.w orally was compared with the reference standard esomeprazole 0.54 mg/200 g b.w orally. The ulcer index was calculated and other biochemical parameters of gastric juice were estimated. The ulcer index of combination showed significant (P < 0.05) reduction while other biochemical parameters like volume, pH, free acidity and total acidity of gastric juice showed highly significant (P < 0.001) reduction when compared to control and standard esomeprazole. The percentage protection of combination was 85% as compared to standard esomeprazole 80% in pylorus ligation model. In the aspirin induced model the percentage protection of combination was 90% as compared to standard esomeprazole 85%. Thus the combination group was found to be synergistic in nature when compared to esomeprazole alone in both the models.


Keywords:

Cite this article:
Nitin M, Mohan Reddy U, Sayeed Ul Hasan SM. Pharmacodynamic influence of vitamin C and Esomeprazole on gastro protection in pylorus ligation and aspirin induced ulcers in rats. Research J. Pharmacology and Pharmacodynamics.2012; 4(3): 176-180.

Cite(Electronic):
Nitin M, Mohan Reddy U, Sayeed Ul Hasan SM. Pharmacodynamic influence of vitamin C and Esomeprazole on gastro protection in pylorus ligation and aspirin induced ulcers in rats. Research J. Pharmacology and Pharmacodynamics.2012; 4(3): 176-180.   Available on: https://rjppd.org/AbstractView.aspx?PID=2012-4-3-20


Recomonded Articles:

Pharmacological Profile of Terminalia chebula Retz. and Willd. (Haritaki) in Ayurveda with Evidences

Author(s): Sudhanshu Kumar Meher, Purnendu Panda, Banmali Das, G. C. Bhuyan, Dr. K. K. Rath

DOI: 10.5958/2321-5836.2018.00023.X         Access: Open Access Read More

Chamomile: A Review

Author(s): Sachin Aglawe, Amol Gayke, Kavita Sharma, Sonali Jadhav, Sanjivani Gore, Bhagyashri Pandit, Sonali Valate, Mayuri Wagh

DOI: 10.5958/2321-5836.2020.00003.8         Access: Open Access Read More

A review on pharmacological activities of Naravelia zeylanica

Author(s): Nikhil P. Varghese, Shekshavali T. , Prathib B., I.J. Kuppast

DOI: 10.5958/2321-5836.2017.00007.6         Access: Open Access Read More

Review Literature: Andrographis paniculata

Author(s): Madhavi Sahu, S. Prakash Rao

DOI: 10.5958/2321-5836.2018.00031.9         Access: Open Access Read More

Important uses of Amalaki (Emblica officinalis) in Indian system of Medicine with Pharmacological Evidence

Author(s): Sanjib Kumar Das, Anuradha Das, Banamali Das, Purnendu Panda, G. C. Bhuyan, Bipin Bihari Khuntia

DOI: 10.5958/2321-5836.2017.00036.2         Access: Open Access Read More

Anti Gastric Ulcer Studies on Certain Siddha Drugs

Author(s): D Benito Johnson, Appalaraju Gorle, Sai Kishore Paleti , Ashok Javvadi.

DOI: Not Available         Access: Open Access Read More

Effect of Squalene in surgically induced Gastro-oesophageal Reflux Disease on rats

Author(s): Lubna Azmi, Shyam Sundar Gupta, Ila Shukla, Padam Kant, O. P. Sidhu, Ch. V. Rao

DOI: 10.5958/2321-5836.2017.00001.5         Access: Open Access Read More

Antiulcer Activity of Colebrookea oppositifolia Sm

Author(s): MM Ghaisas, Surbhi Sharma, GP Ganu, RP Limaye.

DOI: Not Available         Access: Open Access Read More

A Detailed Review on: Recent Advances, Pathophysiological Studies and Mechanism of Peptic Ulcer

Author(s): Akanksha Pandey, Nikita Saraswat, Pranay Wal, Rashmi Saxena Pal, Ankita Wal, Deepa Maurya

DOI: 10.5958/2321-5836.2019.00029.6         Access: Open Access Read More

A Short Review of Cressa cretica

Author(s): Anita S Wanjari, Namrata B. Chouragade.

DOI: 10.5958/2321-5836.2015.00022.1         Access: Open Access Read More

Evaluation of Antiulcer Activity of Piper betel Leaves Extract in Rats

Author(s): Neeraj S Vyawahare, Virendra G Kagathara, RG Katedeshmukh, Pushpendra K Sharma, Smeeta M Mohod

DOI: Not Available         Access: Open Access Read More

A Review on Urticaria

Author(s): Rohit R. Patil, Mayur A. Chaudhari, Tushar A. Deshmukh

DOI: 10.5958/2321-5836.2018.00016.2         Access: Open Access Read More

Amelioration of Gastric Lesions by Avocado (Persea americana) fruit extract on Indomethacin as well as Ethanol induced Ulcerated Experimental rats

Author(s): U.S. Mahadeva Rao, Bizuneh Adinew

DOI: Not Available         Access: Open Access Read More

Antidiarrhoeal Activity of Bark Extracts of Caesalpinia sappan. Linn.

Author(s): Rasheed Ahmed, KL Senthilkumar, M Rajkumar.

DOI: Not Available         Access: Open Access Read More

Pharmacological Studies on Drug-Drug Interactions between Antidiabetic Drug (Glibenclamide) and Selective Anti-HIV Drug (Lamivudine) in Rats and Rabbits

Author(s): Bhavimani Guru, Nitin M.

DOI: 10.5958/2321-5836.2017.00020.9         Access: Open Access Read More

Molecular docking and synthesis of 1, 2, 4 - triazin analogue of diclofenac as potential ligand for parkinson’s

Author(s): Sudhakar P, Poorana Pushkalai S, Sabarinath C, Priyadharshini S, Haripriya S

DOI: 10.5958/2321-5836.2018.00002.2         Access: Open Access Read More

Evaluation of Antiulcer Activity of Coccinia grandis Leaves.

Author(s): C Girish, S Vineela, Y NarasimhaReddy, OVS Reddy, KK Rajasekhar, V Shankarananth.

DOI: Not Available         Access: Open Access Read More

Antiulcer Effect of Vitamin E with Lansoprazole in Treating Peptic Ulcer in Rats

Author(s): Prasad K, Nitin M, Chetan M, Girish M, Krishna Kumar.

DOI: Not Available         Access: Open Access Read More

Management of Male Infertility by Neutraceutical: A Review

Author(s): SC Shivhare, Arjun O Patidar, KG Malviya, K Venkatesh , Kuldeep Rathod.

DOI: Not Available         Access: Open Access Read More

Influence of Anastrozole on Glimepiride in Experimental Animals

Author(s): DK Suresh, Mangesh Gavali, Vivek Ingale, Bhaumik Thakar, Md. Saifuddin K, Raghvendra Rao.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 

Journal Policies & Information



Quick Links

Latest Issues

Popular Articles


Recent Articles



Neuroprotective Activity of Epiphyllum oxypetallum Leaves Extract on Scopolamine Induced Alzhemier’s Disease Model
Artificial Intelligence in Pharmacology Research
Review on Immunomodulatory activity of Medicinal plants by Computational Methods
A Comprehensive Review on Pharmacognostical and Pharmacological properties of Strobilanthes kunthiana Plant
Anti-Bronchitis Effects of Grewia hirsuta Vhl Extract in Cigarette Smoke Model
To Determine the Risk Assessment and Preventive Strategies of Deep Vein Thrombosis among patients admitted in Critical Care Unit
Manganese Nanoparticles in Diagnostics and in Identifying the Antitumor Activity of Viper Venom in Experiment
Pharmacological and Phytochemical Investigation of Ulcer Protective property Catunaregam spinosa Linn.
Review on Nanotechnology for Anthelmintic Resistance against Parasites Management
A Review on Anti-depressant and Anti-stress Activities of some Medicinal Plants
A Literature Review on Premenstrual Syndrome and Premenstrual Dysphoric Disorder
A Systematic Review on Phytochemical Constituents and Pharmacological activities Ricinus communis plant
Pharmacological Review on Orthopoxvirus
Anti-Anxiety Activity of Hydroalcoholic Extract of Ficus religiosa Leaves in Experimental Animals
Ertugliflozin: A Novel Drug for Control of Type-2 Diabetes
Formation and Herbal Prevention for Kidney Stone
Breaking Ground: A Review of Brenzavvy - The newly approved treatment for type 2 Diabetes mellitus
In Vitro and In Vivo Evalution of Anti-Asthmatic Activity of Leaves of Sida veronicafolia (Lam)
Comparative Study of Antibacterial activity of neem leaf extract against standard benzyl penicillin by using In vitro cup plate method
Evaluation of Anti Ulcer activity of Calycopteris floribunda Lams leaf extract in wistar rats

Tags


About Journal

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) (ISSN: print-0975-4407, online- 2321-5836) is an international, peer-reviewed journal, devoted to Pharmacology, Pharmacodynamics and Medical Sciences. The aim of RJPPD is to increase the impact of pharmacological research both in academia and industry, with strong emphasis on quality and originality. RJPPD publishes Original research Articles, Short Communications, Review Articles in all areas of pharmacology, pharmacokinetics and human physiology.

The journal is published quaterly every year in last week of March, June, September and December (i.e. 4 issues in each calendar year).    
Read More  

Visitors

Today: 559
Yesterday: 1805
Total: 1339401