C Girish, S Vineela, Y NarasimhaReddy, OVS Reddy, KK Rajasekhar, V Shankarananth.
C. Girish3*, S. Vineela1, Y. NarasimhaReddy2, O.V.S. Reddy3, K.K. Rajasekhar4 and V. Shankarananth4.
3 Dept of Biochemistry S.V. University, Tirupati.517-501.
1 MAM College of Pharmacy, Narsaraopet, Guntur.
2University College of Pharmaceutical Sciences, Kakatiya University, Warangal.
4 Sri Padmavathi School of Pharmacy, Tirupati.
Volume - 3,
Issue - 2,
Year - 2011
The anti-ulcer activity aqueous extract of leaves of Coccinia grandis was investigated in pylorus ligation and ethanol induced ulcer models in experimental rats. In both models the common parameter determined was ulcer index. Aqueous extract of Coccinia grandis at doses of 250 and 500 mg/kg produced significant inhibition of the gastric lesions induced by pylorus ligation induced ulcer and ethanol induced gastric ulcer .The extract (250 mg/kg & 500 mg/kg) showed significant (P<0.05) reduction in gastric volume, free acidity and ulcer index as compared to control. This present study indicates that aqueous extract of Coccinia grandis have potential anti- ulcer activity in the both models. These results may further suggest that the extract was found to possess antiulcerogenic as well as ulcer healing properties, which might be due to its antisecretory activity.
Cite this article:
C Girish, S Vineela, Y NarasimhaReddy, OVS Reddy, KK Rajasekhar, V Shankarananth. Evaluation of Antiulcer Activity of Coccinia grandis Leaves. Research J. Pharmacology and Pharmacodynamics. 2011; 3(2): 92-95.