Author(s): Yasa Swetha, Sunanda, Rajanikar, Ashwini K Reddy, Srivally, Md Masoom.

Email(s): yasa.swetha@yahoo.com

DOI: Not Available

Address: Yasa Swetha*, Sunanda, Rajanikar, Ashwini K. Reddy, Srivally, Md. Masoom.
Dept of Pharmacology, Malla Reddy Institute of Pharmaceutical Sciences (MRIPS), JNTU, Hyderabad 500054.
*Corresponding Author

Published In:   Volume - 4,      Issue - 6,     Year - 2012


ABSTRACT:
Study was aimed to evaluate the possible antiulcer activity of methanolic extract of leaves of Gymnema sylvestre for its ability to inhibit gastric secretion and to protect gastro duodenal mucosa. G. sylvestre leaves were successively extracted with methanol and is subjected to phytochemical screening to identify different phytoconstituents. Ld50 studies were conducted up to the dose level of 2g/kg by following OECD guidelines. No mortality was observed with the extract up to the maximum dose level of 2g/kg. Anti-Ulcer activity was evaluated in various animal models like pylorus ligation, indomethacin an non steroidal anti inflammatory drug (NSAID) and forced swim stress induced gastric ulcers in rats. Preliminary phytochemical studies revealed the presence of saponins, sterols, glycosides, alkaloids, resins, carbohydrates, flavonoids, tannins, proteins, triterpenoids, phenolic compounds in the extract of G. sylvestre. Further the Methanolic Extract of G. sylvestre (MEGS) at 400mg/kg p.o. significantly (P < 0.01) reduced ulcer index when compared with the methanolic extracts at 200mg/kg and 100mg/kg p.o in rats. Ranitidine (30mg/kg p.o.) was used as the reference drug. The present study revealed that the antiulcer activity of MEGS may be due to the presence of phytochemical constituents such as saponins, flavanoids, tannins, sterols, glycosides, alkaloids, resins, carbohydrates, proteins, triterpenoids as these phytochemical constituents were already reported for the above mentioned effects.


Cite this article:
Yasa Swetha, Sunanda, Rajanikar, Ashwini K Reddy, Srivally, Md Masoom. Phytochemical and Pharmacological Studies of Methanolic Extract of Gymnema sylvestre leaves: an Approach for in vivo Antiulcer Activity. Research J. Pharmacology and Pharmacodynamics. 2012; 4(6): 368-372.


Recomonded Articles:

Author(s): Chunendra Kumar, Shiv Shankar Shukla, Ravindra Kumar Pandey

DOI: 10.5958/2321-5836.2017.00016.7         Access: Open Access Read More

Author(s): Jeevanagouda Patil, Kuppast I.J, Kishan Kumar M A, Kishan K G

DOI: 10.5958/2321-5836.2016.00032.X         Access: Open Access Read More

Author(s): M. Vanajakshi, J.H. Virupaksha, Shilpa Maria

DOI: 10.5958/2321-5836.2016.00033.1         Access: Open Access Read More

Author(s): Nikhil P. Varghese, Shekshavali T. , Prathib B., I.J. Kuppast

DOI: 10.5958/2321-5836.2017.00007.6         Access: Open Access Read More

Author(s): MM Ghaisas, Surbhi Sharma, GP Ganu, RP Limaye.

DOI: Not Available         Access: Open Access Read More

Author(s): Shilpa Maria, IJ Kuppast, JH Virupaksha, M Vanajakshi, K Prasad.

DOI: 10.5958/2321-5836.2015.00033.6         Access: Open Access Read More

Author(s): MA Halkai, Arun Patil, MD Akhil Ahmed, AK Beknal .

DOI: 10.5958/2321-5836.2016.00004.5         Access: Open Access Read More

Author(s): Ashish Singhai, PK Singour, G Garg, RS Pawar, UK Patil.

DOI: Not Available         Access: Open Access Read More

Author(s): Vandna Dewangan, Himanshu Pandey

DOI: 10.5958/2321-5836.2017.00039.8         Access: Open Access Read More

Author(s): Sudhanshu Kumar Meher, Purnendu Panda, Banmali Das, G. C. Bhuyan, Dr. K. K. Rath

DOI: 10.5958/2321-5836.2018.00023.X         Access: Open Access Read More

Author(s): Sudhakar P, Poorana Pushkalai S, Sabarinath C, Priyadharshini S, Haripriya S

DOI: 10.5958/2321-5836.2018.00002.2         Access: Open Access Read More

Author(s): Sachin R Patil,Swati Patil, M B Patil, Ravi Kumar , Mahesh S Paschapur.

DOI: Not Available         Access: Open Access Read More

Author(s): Mule VS, Potdar VH, Jadhav SD , Disouza J I.

DOI: Not Available         Access: Open Access Read More

Author(s): D Benito Johnson, Appalaraju Gorle, Sai Kishore Paleti , Ashok Javvadi.

DOI: Not Available         Access: Open Access Read More

Author(s): Neeraj S Vyawahare, Virendra G Kagathara, RG Katedeshmukh, Pushpendra K Sharma, Smeeta M Mohod

DOI: Not Available         Access: Open Access Read More

Author(s): Prasad K, Nitin M, Chetan M, Girish M, Krishna Kumar.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags