Research Journal of Pharmacology and Pharmacodynamics

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2321-5836 (Online)
0975-4407 (Print)


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Evaluation of Antidiarrhoeal and Antiulcer Activities of Hydroalcoholic Extract of Luffa aegyptiaca Fruits

Author(s): B Bavaji Naidu, MN Palaksha, K Ravishankar, M Naveen, N Basha.

Email(s): palaksha.mn@gmail.com

DOI: Not Available

Address: B. Bavaji Naidu, M.N. Palaksha*, K. Ravishankar, M. Naveen and N. Basha
Sri Sai Aditya Institute of Pharmaceutical Sciences and Research, Surampalem, E.G.Dist-533437.
*Corresponding Author

Published In:   Volume - 6,      Issue - 4,     Year - 2014

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ABSTRACT:
The present study investigates the antidiarrhoeal and antiulcer activities of hydroalcoholic fruit extract of Luffa aegyptiaca. The fruits were shade dried and made into a coarse powder which was then subjected to continuous hot extraction in Soxhlet apparatus with hydroalcoholic solvent (ethanol 50% + water 50%) and the residual marc was collected. The extract was used to screen for their antidiarrhoeal and antiulcer activities. The antidiarrhoeal activity was evaluated at two different concentrations viz., 250 mg/kg and 500 mg/kg of the above extract using Castor oil induced diarrhea method in experimental rats. Extract with 500 mg/kg concentration showed significant reduction of induced diarrhoea as compared to the control group animals. But, the antidiarrhoeal activity was found to be less than that of standard drug, Diphenoxylate (5 mg/kg). Anti-ulcer activity was carried out by pylorus ligation method induced gastric ulcer. Ulcer protective action was observed at a dose of 500 mg/kg of Hydroalcoholic fruit extract of Luffa aegyptiaca, which was found to be closer to the standard drug, Famotidine (10 mg/kg).


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Cite this article:
B Bavaji Naidu, MN Palaksha, K Ravishankar, M Naveen , N Basha. Evaluation of Antidiarrhoeal and Antiulcer Activities of Hydroalcoholic Extract of Luffa aegyptiaca Fruits. Research Journal of Pharmacology and Pharmacodynamics. 2014; 6(4):184-189.

Cite(Electronic):
B Bavaji Naidu, MN Palaksha, K Ravishankar, M Naveen , N Basha. Evaluation of Antidiarrhoeal and Antiulcer Activities of Hydroalcoholic Extract of Luffa aegyptiaca Fruits. Research Journal of Pharmacology and Pharmacodynamics. 2014; 6(4):184-189.   Available on: https://rjppd.org/AbstractView.aspx?PID=2014-6-4-12


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Research Journal of Pharmacology and Pharmacodynamics (RJPPD) (ISSN: print-0975-4407, online- 2321-5836) is an international, peer-reviewed journal, devoted to Pharmacology, Pharmacodynamics and Medical Sciences. The aim of RJPPD is to increase the impact of pharmacological research both in academia and industry, with strong emphasis on quality and originality. RJPPD publishes Original research Articles, Short Communications, Review Articles in all areas of pharmacology, pharmacokinetics and human physiology.

The journal is published quaterly every year in last week of March, June, September and December (i.e. 4 issues in each calendar year).    
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