Research Journal of Pharmacology and Pharmacodynamics

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2321-5836 (Online)
0975-4407 (Print)


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Assessment of Hypolipidemic Effect of Ardisia solanacea in high fat diet induced rats

Author(s): Pradeep Kumar Samal

Email(s): samalpharmacology@rediffmail.com

DOI: Not Available

Address: Pradeep Kumar Samal
SLT Institute of Pharmaceutical Sciences, Guru Ghasidas Vishwavidyalaya, Bilaspur, Chhattisgarh.
*Corresponding Author

Published In:   Volume - 5,      Issue - 3,     Year - 2013

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ABSTRACT:
Ardisia solanacea leaves were used for the evaluation of hypolipidemic effects against high fat diet induced hyperlipidemia in rats. The leaves were dried in shade for 20 days, powdered and extracted with Alcohol. Preliminary phytochemical analysis found the presence of phenolic compounds, glycosides and flavonoids in the alcoholic extract. Acute oral toxicity study of alcoholic extract of Ardisia solanacea leaves (AEAS) was conducted in mice by using OECD guideline no.425 and it was found to safe up to the dose label of 2000mg/kg of body weight p.o. The extract at dose of 100 and 200 mg/kg was administered orally once daily for 10 days. Gemfibrozil (50mg/kg p.o.) was used as reference standard. AEAS (200 mg/kg p.o) were potentially reduced average body weight gain and plasma lipids levels including Total cholesterol (TC), Triglycerides (TG), Low density lipoproteins (LDL), Very low-density lipoproteins (VLDL) and enhanced High-density lipoprotein (HDL) level than AEAS (100 mg/kg p.o) while AEAS were reduce plasma glucose levels in a dose dependent manner. The results of this study strongly indicate that AEAS has potent Hypolipidemic effects against high fat diet induced hyperlipidemia in rats.


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Cite this article:
Pradeep Kumar Samal. Assessment of Hypolipidemic Effect of Ardisia solanacea in high fat diet induced rats. Research J. Pharmacology and Pharmacodynamics. 2013; 5(3): 147-150.

Cite(Electronic):
Pradeep Kumar Samal. Assessment of Hypolipidemic Effect of Ardisia solanacea in high fat diet induced rats. Research J. Pharmacology and Pharmacodynamics. 2013; 5(3): 147-150.   Available on: https://rjppd.org/AbstractView.aspx?PID=2013-5-3-15


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Research Journal of Pharmacology and Pharmacodynamics (RJPPD) (ISSN: print-0975-4407, online- 2321-5836) is an international, peer-reviewed journal, devoted to Pharmacology, Pharmacodynamics and Medical Sciences. The aim of RJPPD is to increase the impact of pharmacological research both in academia and industry, with strong emphasis on quality and originality. RJPPD publishes Original research Articles, Short Communications, Review Articles in all areas of pharmacology, pharmacokinetics and human physiology.

The journal is published quaterly every year in last week of March, June, September and December (i.e. 4 issues in each calendar year).    
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