Pancreatic Polypeptide: Biologically Active Neuropeptide and their Clinical Significance

Hemlata Dewangan; Jhakeshwar Prasad; Trilochan Satapathy

doi:10.5958/2321-5836.2017.00038.6

Research Journal of Pharmacology and Pharmacodynamics

ISSN

2321-5836 (Online)
0975-4407 (Print)

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Pancreatic Polypeptide: Biologically Active Neuropeptide and their Clinical Significance

Author(s): Hemlata Dewangan, Jhakeshwar Prasad, Trilochan Satapathy

Email(s): babydewangan93@gmail.com

DOI: 10.5958/2321-5836.2017.00038.6

Address: Hemlata Dewangan*, Jhakeshwar Prasad, Trilochan Satapathy
Columbia Institute of Pharmacy, Tekari, Raipur, Chhattisgarh, Pin-493111, India
*Corresponding Author

Published In: Volume - 9, Issue - 4, Year - 2017

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ABSTRACT:
Imbalances in normal regulation of food intake can cause obesity and related disorders. Pancreatic polypeptide (PP) share considerable amino acid sequence homology act as a robust anorexigenic hormone effectively modulates food intake and energy homeostasis, thus potentially aiding anti-obesity therapeutics. They are found in widely disparate locations, including the pancreas (PP), the distal gut (PYY), and the central nervous system (NPY). Intra-gastric and intra-intestinal infusion of nutrients stimulate PP secretion from the gastrointestinal tract, in turn that causes vagal stimulation and exerts complex actions via the neuropeptide Y4 receptor (Family of G-protein coupled Receptors) in arcuate nucleus of the hypothalamus, there by subsequently activating key hypothalamic nuclei and dorsal vagal complex of the brainstem to influence energy homeostasis and body composition. In this review our efforts have been devoted to summarize the detail about the pancreatic polypeptide their functions and mechanisms.

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Cite this article:
Hemlata Dewangan, Jhakeshwar Prasad, Trilochan Satapathy. Pancreatic Polypeptide: Biologically Active Neuropeptide and their Clinical Significance. Res. J. Pharmacology & Pharmacodynamics.2016; 8(3): 211-218. doi: 10.5958/2321-5836.2017.00038.6

Cite(Electronic):
Hemlata Dewangan, Jhakeshwar Prasad, Trilochan Satapathy. Pancreatic Polypeptide: Biologically Active Neuropeptide and their Clinical Significance. Res. J. Pharmacology & Pharmacodynamics.2016; 8(3): 211-218. doi: 10.5958/2321-5836.2017.00038.6 Available on: https://rjppd.org/AbstractView.aspx?PID=2017-9-4-10