ABSTRACT:
Oral controlled drug conveyance frameworks, being the most broadly used type of supported drug conveyance frameworks because of the intrinsic benefits of oral organization, offer both consistent and variable arrival of medications. These frameworks display a trademark example of medication discharge wherein the medication fixation stays inside the helpful window for a lengthy timeframe, guaranteeing supported restorative activity. Besides, they are normally utilized as a solitary dose structure. The current review means to create and assess supported discharge microspheres of Nateglinide utilizing Ascophyllum, a characteristic polymer, alongside HypromelloseK15 and Deacetylated chitin. The ionotropic gelation procedure has been utilized for the arrangement of these medication stacked microspheres. The improvement of such conveyance frameworks assumes an essential part in upgrading drug viability and patient consistence, as they offer a few benefits like better bioavailability, decreased dosing recurrence, and limited secondary effects. These frameworks likewise give a way to defeat difficulties related with regular medication conveyance strategies, like unfortunate medication strength, low solvency, and enzymatic debasement. By figuring out supported discharge microspheres, a controlled arrival of the medication can be accomplished, prompting delayed restorative impacts and worked on quiet results. Moreover, the decision of regular polymers in this study is worthwhile as they are biocompatible, biodegradable, and show great medication discharge qualities. The utilization of Ascophyllum, HypromelloseK15, and Deacetylated chitin together in the plan considers enhancement of medication discharge profiles and further developed drug exemplification productivity. Through fastidious readiness and exhaustive examination, this exploration attempt plans to add to the improvement of effective oral conveyance frameworks that can meet the restorative requirements of patients, giving maintained and designated drug discharge for constant sicknesses.
Cite this article:
Ishwar Kale, Jagruti Patil, Sanskruti Shingane. Preparation Evaluation of Microspheres of Nateglinide for the Treatment of Diabetes Mellitus. Research Journal of Pharmacology and Pharmacodynamics.2024;16(3):156-0. doi: 10.52711/2321-5836.2024.00027
Cite(Electronic):
Ishwar Kale, Jagruti Patil, Sanskruti Shingane. Preparation Evaluation of Microspheres of Nateglinide for the Treatment of Diabetes Mellitus. Research Journal of Pharmacology and Pharmacodynamics.2024;16(3):156-0. doi: 10.52711/2321-5836.2024.00027 Available on: https://rjppd.org/AbstractView.aspx?PID=2024-16-3-4
REFERENCE:
1. Malviya VR, Pande SD, Bobade NN. Preparation and evaluation of sustained release beads of zolmitriptan hydrochloride. Research Journal of Pharmacy and Technology. 2019;12(12):5972-6.
2. Saisree R, Bhanja S, Das S, Bhavana V, Sudhakar M, Panigrahi BB. Formulation and evaluation of mucoadhesive microspheres of valsartan. Research Journal of Pharmacy and Technology. 2019; 12(2): 669-77.
3. Chintale AG, Kadam VS, Maske KS, Raut DB, Kale SV, Rai SD. Recent advances in microsphere drug delivery system: a review. Research Journal of Pharmacy and Technology. 2013; 6(3):307-12.
4. Sachan AK, Singh S, Kumari K, Devi P. Floating Microsphere of Curcumin as Targeted Gastro-retentive Drug Delivery System. Research Journal of Pharmacy and Technology. 2021; 14(10): 5202-6.
5. Malviya V, Ladhake V, Gajbiye K, Satao J, Tawar M. Design and characterization of phase transition system of zolmitriptan hydrochloride for nasal drug delivery system. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 May 31; 13(3): 4942-51.
6. Malviya VR, Pande SD. Road CKN. Preparation ad Evaluation of Zolmitriptan Hydrochloride Lozenge. J Pharma Res. 2019; 8(8): 624-9.
7. Malviya V, Thakur Y, Gudadhe SS, Tawar M. Formulation and evaluation of natural gum based fast dissolving tablet of Meclizine hydrochloride by using 3 factorial design 2. Asian Journal of Pharmacy and Pharmacology. 2020; 6(2): 94-100.
8. Malviya V. Preparation and Evaluation of Emulsomes as a Drug Delivery System for Bifonazole. Indian Journal of Pharmaceutical Education and Research. 2021 Jan 1; 55(1): 86-94.
9. Malviya VR, Tawar MG. Preparation and evaluation of oral dispersible strips of teneligliptin hydrobromide for treatment of diabetes mellitus. International Journal of Pharmaceutical Sciences and Nanotechnology. 2020 Jan 31; 13(1): 4745-52.
10. Malviya V, Manekar S. Design, development and evaluation of aceclofenac and curcumin agglomerates by Crystallo Co-Agglomeration technique. Research Journal of Pharmacy and Technology. 2021; 14(3): 1535-41.
11. Burange PJ, Tawar MG, Bairagi RA, Malviya VR, Sahu VK, Shewatkar SN, Sawarkar RA, Mamurkar RR. Synthesis of silver nanoparticles by using Aloe vera and Thuja orientalis leaves extract and their biological activity: a comprehensive review. Bulletin of the National Research Centre. 2021 Dec; 45:1-3.
12. Sivaprasad S, Alagarsamy V, Bharathi MP, Krishna PV, Kanna KS. Formulation and evaluation of mucoadhesive floating microspheres of repaglinide. Research Journal of Pharmacy and Technology. 2021; 14(11): 5673-9.
13. Basu SK, Kavitha K, Rupeshkumar M. Formulation and Evaluation of Tramadol Hydrochloride Microspheres for Oral Delivery. Research Journal of Pharmacy and Technology. 2010; 3(3): 877-81.
14. Rao A, Malothu N, Rao AN, Naga RB, Mohammed BJ. Formulation and evaluation of floating microspheres of sitagliptin. Research Journal of Pharmacy and Technology. 2023; 16(5): 2251-6.
15. Raghuveer P, Rani AP, Desavatu M, Chaitanya AS, Srikar G. Formulation of Monodisperse Alginate (Micro) Spheres Containing Tenofovir for Extended-Release Dosage Form. Research Journal of Pharmacy and Technology. 2017; 10(4): 1070-6.
16. Malviya V, Pande S. Development and Evaluation of Fast dissolving Film of Fluoxetine hydrochloride. Research Journal of Pharmacy and Technology. 2021; 14(10): 5345-50.
17. Cheng T, Gao H, Liu G, Pu Z, Wang S, Yi Z, Wu X, Yang H. Preparation of core-shell heterojunction photocatalysts by coating CdS nanoparticles onto Bi4Ti3O12 hierarchical microspheres and their photocatalytic removal of organic pollutants and Cr (VI) ions. Colloids and Surfaces A: Physicochemical and Engineering Aspects. 2022 Jan 20; 633:127918.
18. Malviya V. Design and Characterization of Thermosensitive Mucoadhesive Nasal Gel for Meclizine Hydrochloride: Thermosensitive Nala Gel of Meclizine HCL. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Feb 28; 15(1): 5782-93.
19. Malviya V, Burange P, Thakur Y, Tawar M. Enhancement of Solubility and Dissolution Rate of Atazanavir Sulfate by Nanocrystallization. Indian Journal of Pharmaceutical Education and Research. 2021 Jul 1; 55(3): S672-80.
20. Nasr M, Cavalu S, Saber S, Youssef ME, Abdelhamid AM, Elagamy HI, Kamal I, Gaafar AG, El-Ahwany E, Amin NA, Girgis S. Canagliflozin-loaded chitosan-hyaluronic acid microspheres modulate AMPK/NF-κB/NLRP3 axis: A new paradigm in the rectal therapy of ulcerative colitis. Biomedicine & Pharmacotherapy. 2022 Sep 1; 153:113409.
21. Malviya, Vedanshu, Mukund Tawar, Prashant Burange, and Rahul Jodh. "A brief review on resveratrol." (2022): 157-162.
22. Jodh R, Tawar M, Burange P, Malviya V. A pharmacological review on orchid Dactylorhiza hatagirea (D. Doon) soo. Asian Journal of Pharmacy and Technology. 2022; 12(2): 141-5.
23. Malviya V, Arya A, Burange P, Gajbhiye K, Rathod G, Tawar M. To evaluate the cardioprotective effect of hydroalcoholic extract of Matricaria chamomilla linn in isoproterenol induced myocardial infarction in wistar rats. Research Journal of Pharmacy and Technology. 2022; 15(9): 3887-92.
24. Wang S, Liu S, Liu C, Tang S, Gu D, Tian J, Yang Y. Affinity screening of potential anti-obesity and anti-diabetic component from pomegranate peel by co-immobilization of lipase and α-amylase using carbon nanotube and hydrogel. Process Biochemistry. 2023 Mar 1; 126:51-60.
25. Malviya V, Tawar M, Burange P, Bairagi R. Preparation and Characterization of Gastroreten-tive Sustained Release In-situ Gel of Lafutidine. International Journal of Pharmaceutical Sciences and Nanotechnology. 2022 Dec 12; 15(6): 6216-28.
26. Bordoloi R, Ahmed AB, Bhattacharya K. Pharmacoscintigraphic evaluation and antidiabetic efficacy of gliclazide-loaded 99mTc-labelled mucoadhesive microspheres. Future Journal of Pharmaceutical Sciences. 2021 Dec; 7:1-27.
27. Malviya V, Pande S. Design and Characterization of pH Dependent Phase Transition System of Almotriptan Malate for Nasal Drug Delivery System by Employing Factorial Design. Ind. J. Pharm. Edu. Res. 2024; 58(1): 76-90.
28. Kumar D, Gautam A, Rohatgi S, Kundu PP. Synthesis of vildagliptin loaded acrylamide-g-psyllium/alginate-based core-shell nanoparticles for diabetes treatment. International Journal of Biological Macromolecules. 2022 Oct 1; 218:82-93.
29. Malviya V. Box-Behnken Modeling Served for the Development and Optimization of Nanoparticles Loaded with Perindopril and Erbumine. Asian Journal of Pharmaceutics. 2023 Sep 15; 17(3).
30. Malviya V. Investigation of In-Vitro Antidiabetic Study, Antioxidant Activity and Anthelminthic Property of Various Extracts of Bitter Cumin Seeds: Antidiabetic Study, Antioxidant Activity, and Anthelminthic Property of Bitter Cumin Seeds. International Journal of Pharmaceutical Sciences and Nanotechnology. 2023 Jul 31; 16(4): 6855-74.