Author(s): Avesh Tamboli, Priyanka Sadaphal, S. D. Mankar, S. B. Bhawar

Email(s): sdmankar655@gmail.com

DOI: 10.52711/2321-5836.2022.00028   

Address: Avesh Tamboli*, Priyanka Sadaphal, S. D. Mankar, S. B. Bhawar
Pravara Rural College of Pharmacy, Pravaranagar (Loni BK), Ahmednagar, Maharashtra, India – 413736.
*Corresponding Author

Published In:   Volume - 14,      Issue - 3,     Year - 2022


ABSTRACT:
Kounis syndrome is characterised by a group of symptoms that manifests as unstable vasospastic or non-vasospastic angina secondary to a hypersensitivity reaction. It was first described by Kounis and Zavras in 1991 as the concurrence of an allergic response with an anaphylactic or anaphylactoid reaction and coronary artery spasm or even myocardial infarction. Since then, this condition has evolved to include a number of mast cell activation disorders associated with acute coronary syndrome. There are many triggering factors, including reactions to multiple medications, exposure to radiological contrast media, poison ivy, bee stings, shellfish, and coronary stents. In addition to coronary arterial involvement, Kounis syndrome comprises other arterial systems with similar physiologies, such as mesenteric and cerebral circulation resulting in ischemia / infraction of the vital organs. The Incidence of this condition is difficult to establish owing to the number of potential instigating factors and its relatively infrequent documentation in the literature. Anaphylaxis rarely manifests as a vasospastic acute coronary syndrome with or without the presence of underlying coronary artery disease. The variability in the underlying pathogenesis produces a wide clinical spectrum of this syndrome. Kounis syndrome is not just a single organ but also a complex multisystem and multiorgan arterial clinical conditions, it affects the coronary, mesenteric, and cerebral arteries and is accompanied by allergy hypersensitivity anaphylaxis involving Skin , respiratory system and vascular system in the context of anaesthesia, surgery, radiology ,oncology or even dental and psychiatric medicine , further it has significantly influences both morbidity and mortality. Kounis syndrome is caused by inflammatory mediators released during allergic insults, post inflammatory cell activation and interactions via multi directional stimuli. A platelet subset of 20% with high and low affinity IgE surface receptors is also involved in this process.


Cite this article:
Avesh Tamboli, Priyanka Sadaphal, S. D. Mankar, S. B. Bhawar. Kounis Syndrome: A Novel Review. Research Journal of Pharmacology and Pharmacodynamics.2022;14(3):165-0. doi: 10.52711/2321-5836.2022.00028

Cite(Electronic):
Avesh Tamboli, Priyanka Sadaphal, S. D. Mankar, S. B. Bhawar. Kounis Syndrome: A Novel Review. Research Journal of Pharmacology and Pharmacodynamics.2022;14(3):165-0. doi: 10.52711/2321-5836.2022.00028   Available on: https://rjppd.org/AbstractView.aspx?PID=2022-14-3-6


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2.    Nicholas G. Kounis, George Hahalis, Akrivi Manola, Taxiarchis V Kourelis, Kounis syndrome (allergic angina and allergic myocardial infarction), Research Gate, In: Angina Pectoris: Etiology, Pathogenesis and Treatment ISBN: 978-1-60456-674-1 2008 Nova Science Publishers, Inc.
3.    Nicholas G. Kounis, Loanna Koniari, Cesare de Gregorio, Dimitris Velissaris, Konstantinos Petalas, Aikaterina Brinia, Stelios F. Assimakopoulos, Christos Gogos, Sophia N. Kounis, George N. Kounis, Gian Franco Calogiuri and Ming Yow Hung. Allergic reactions to current available COVID-19 vaccinations: Pathophysiology Causality And Therapeutic considerations,  MDPI, Vaccines 2021, 9,221. https://doi.org/10.3390/vaccines903022
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