Author(s): D. Benito Johnson, R. Sivasakthi, Ashwini. M, R. Venkatanarayanan

Email(s): benitopharma@gmail.com

DOI: 10.52711/2321-5836.2022.00001   

Address: D. Benito Johnson1*, R. Sivasakthi2, Ashwini. M1, R. Venkatanarayanan3
1Department of Pharmacology, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402.
2Department of Pharmacy Practice, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402.
3Department of Pharmacognosy, RVS College of Pharmaceutical Sciences, Sulur, Coimbatore – 641402.
*Corresponding Author

Published In:   Volume - 14,      Issue - 1,     Year - 2022


ABSTRACT:
Introduction: An inflammatory response appears after activation of immune response. Inflammation is a response to remove the primary cause of cell injury. Dead cells, damage tissue sand initiate the repair process. Inflammation may be of two types acute and chronic. Medicinal plants has a potential source of therapeutic aid has a attended a significant role in all over the world for both human and animals not only in the disease condition but also a potential for maintaining a proper health. The plant Bryophyllum pinnatum species (roots) are evaluated for anti-inflammatory activity. Aim: Anti-inflammatory activity of Bryophyllum pinnatum was evaluated using Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema. Materials and Methods: To prepare methanolic extracts of Bryophyllum pinnatum roots and investigate the anti-inflammatory activity by Carrageenan induced paw oedema, Histamine induced paw oedema and Egg white induced paw oedema. Result: The result obtained indicates that the extract found to have significant (p<0.0001) anti-inflammatory activity in rats. The extract at the test doses 200mg/kg reduced the oedema induced by carrageenan by 41.26% at 3 h, whereas the standard drug showed 47.35% of inhibition ass compared to the control group. Conclusion: The methanolic extract of Bryophyllum pinnatum are safe upto 500mg/kg for continues administration and it can be used as anti inflammatory agent without any harmful effects


Cite this article:
D. Benito Johnson, R. Sivasakthi, Ashwini. M, R. Venkatanarayanan. Anti-Inflammatory Activity Screening of Methanolic Extract of Bryophyllum pinnatum Root. Research Journal of Pharmacology and Pharmacodynamics.2022;14(1):1-3. doi: 10.52711/2321-5836.2022.00001

Cite(Electronic):
D. Benito Johnson, R. Sivasakthi, Ashwini. M, R. Venkatanarayanan. Anti-Inflammatory Activity Screening of Methanolic Extract of Bryophyllum pinnatum Root. Research Journal of Pharmacology and Pharmacodynamics.2022;14(1):1-3. doi: 10.52711/2321-5836.2022.00001   Available on: https://rjppd.org/AbstractView.aspx?PID=2022-14-1-1


REFERENCE:
1.    Text book of pathology by Harsh Mohan 6th edition p.no131.
2.    Abbas A.B.; Lichtman A.H (2009). “Ch.2 Innate Immunity”. In Saunders (Elsevier).
3.    Stedman‟s Medical University Dictionary (Twenty-fifth ed.). Williams and wilkins. (1990)
4.    Latif A, Ashiq K, Ashiq S, Ali E, Anwer I, Qamar S. Phytochemical analysis and in vitro investigation of anti-inflammatory and xanthine oxidase inhibition potential of root extracts of Bryophyllum pinnatum. J Anim Plant Sci. 2020 Feb 1;30(1):219-28.
5.    Mudi SY, Ibrahim H. Activity of Bryophyllum pinnatum S. Kurz extracts on respiratory tract pathogenic bacteria. Bayero Journal of Pure and Applied Sciences. 2008:39-42.
6.    KouitcheuMabeku LB, Eyoum Bille B, Tchouangueu TF, Nguepi E, Leundji H. Treatment of Helicobacter pylori infected mice with Bryophyllum pinnatum, a medicinal plant with antioxidant and antimicrobial properties, reduces bacterial load. Pharmaceutical Biology. 2017 Jan 1;55(1):603-10.
7.    Salami EO, Ozolua RI, Okpo SO, Eze GI, Uwaya DO. Studies on the anti-asthmatic and antitussive properties of aqueous leaf extract of Bryophyllum pinnatum in rodent species. Asian Pacific Journal of Tropical Medicine. 2013 Jun 1;6(6):421-5.
8.    Ogidi OI, Esie NG, Dike OG. Phytochemical, Proximate and Mineral compositions of Bryophyllum pinnatum (Never die) Medicinal plant. Journal of Pharmacognosy and Phytochemistry. 2019;8(1):629-35.
9.    Nwali BU, Okaka ANC, Ibiam UA, Aja PM. Phytochemical composition of Bryophyllum pinnatum Leaves. International Journal of Advanced Biological Research. 2012; 2(4):614- 616.
10.    Okwu DE, Nnamdi FU. Two novel flavonoids from Bryophyllum pinnatum and their anti microbial Activity. Journal of Chemical and Pharmaceutical Research. 2011; 3(2):1-10.
11.    Ncube NS, Afolayan AJ, Okoh AI. “Assessment techniques of antimicrobial properties of natural compounds of plant origin: current methods and future trends”, African J. Biotec. 2008; 7 (12): 1797-1806.

Recomonded Articles:

Author(s): Syed Sagheer Ahmed, Chandra Prakash. K, Saba Tabassum, Noor Salma, Ahalya Devi. K H

DOI: 10.5958/2321-5836.2019.00003.X         Access: Open Access Read More

Author(s): Aswani P. S., Kshirod Kumar Ratha, Dighe Dattatray Pandurang, M. M. Rao, Remya Vijayan

DOI: 10.5958/2321-5836.2018.00008.3         Access: Open Access Read More

Author(s): Shameer Pasha, Mohamed Khaleel, Sukhen Som.

DOI: Not Available         Access: Open Access Read More

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, BK Das, MM Rao, GChD Naga Lakshmi.

DOI: 10.5958/2321-5836.2015.00011.7         Access: Open Access Read More

Author(s): Kishan K G, Shekshavali. T, Kuppast I.J, Kishan Kumar MA, Jeevanagouda Patil

DOI: 10.5958/2321-5836.2016.00030.6         Access: Open Access Read More

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, Das, GC Nanda.

DOI: Not Available         Access: Open Access Read More

Author(s): T. Shekshavali, S. Roshan

DOI: 10.5958/2321-5836.2016.00031.8         Access: Open Access Read More

Author(s): Nikhil P. Varghese, Shekshavali T. , Prathib B., I.J. Kuppast

DOI: 10.5958/2321-5836.2017.00007.6         Access: Open Access Read More

Author(s): Jeevanagouda Patil, Kuppast I.J, Kishan Kumar M A, Kishan K G

DOI: 10.5958/2321-5836.2016.00032.X         Access: Open Access Read More

Author(s): U. S. Jijith , C. R. Sudhakaran Nair, K. Pramod

DOI: 10.5958/2321-5836.2016.00001.X         Access: Open Access Read More

Author(s): Indranil Chanda, Smriti Rekha Chanda , Sadhan Kr Dutta.

DOI: Not Available         Access: Open Access Read More

Author(s): Sanjib Kumar Das, Anuradha Das, Banamali Das, Purnendu Panda, G. C. Bhuyan, Bipin Bihari Khuntia

DOI: 10.5958/2321-5836.2017.00036.2         Access: Open Access Read More

Author(s): Suneel Kumar A, Venkatarathanamma. V, Naga Saibabu V, Nageswara Rao Tentu, Pavan Kumar Kota, K. Suneel Kumar, A. Vijayalakshmi

DOI: 10.5958/2321-5836.2017.00009.X         Access: Open Access Read More

Author(s): Sambrekar Sudhir N, Patil PA, Suhas A Patil.

DOI: Not Available         Access: Open Access Read More

Author(s): Mohammed Haleel P M , Rashid K, C. Senthil Kumar

DOI: 10.5958/2321-5836.2018.00005.8         Access: Open Access Read More

Author(s): Kadiri Sunil Kumar, S Mounica, Rajesh Behera, K Vijay Kumar, Y Shanmukh Sai, R Suthakaran

DOI: 10.5958/2321-5836.2016.00013.6         Access: Open Access Read More

Author(s): Rohit J. Bhor, Harshala Damdhar, Geeta Kokate, Maduri Salve, Swati Andhale

DOI: 10.5958/2321-5836.2016.00025.2         Access: Open Access Read More

Author(s): Sudhanshu Kumar Meher, Purnendu Panda, Banmali Das, G. C. Bhuyan, Dr. K. K. Rath

DOI: 10.5958/2321-5836.2018.00023.X         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags