Author(s):
Peeyush Kumar, Saket Singh Chandel, Neelima Yadav, Aayush Vaishnaw, Manali Rai
Email(s):
singhpharma@gmail.com
DOI:
10.52711/2321-5836.2025.00039 
Address:
Peeyush Kumar1, Saket Singh Chandel2*, Neelima Yadav2, Aayush Vaishnaw2, Manali Rai2
1Research Scholar, Department of Pharmacology, Dr. C.V. Raman Institute of Pharmacy, Dr. C.V. Raman University, Kota, Bilaspur, Chhattisgarh - 495113, India.
2Faculty of Pharmacy, Dr. C.V. Raman Institute of Pharmacy, Dr. C.V. Raman University, Kota, Bilaspur, Chhattisgarh - 495113, India.
*Corresponding Author
Published In:
Volume - 17,
Issue - 4,
Year - 2025
ABSTRACT:
Background: Free radicals and oxidative stress are the causes of Alzheimer's dementia, a neurodegenerative condition. Antioxidants can prevent Alzheimer's disease and improve memory. Red grape seeds have demonstrated the ability to enhance cognition in rats afflicted with Alzheimer’s disease due to their antioxidant properties. Materials and Procedures: Male rats were IP-infused with 120mg/kg body weight of D-galactose to create an Alzheimer's model. On days 30 and 60, biochemical parameters were assessed. Results: We found that the levels of several biomarkers, including glutamine content, glutamine synthetase, glutamate dehydrogenase, and glutaminase activity, had significantly improved. Conclusions: Based on our findings, red grape seeds may contain active components that can help treat and prevent cognitive deficits associated with Alzheimer's disease.
Cite this article:
Peeyush Kumar, Saket Singh Chandel, Neelima Yadav, Aayush Vaishnaw, Manali Rai. Red Grape Seed Extract for Memory Enhancement in Alzheimer’s Disease in Rats with Reference to the Glutamate Metabolism. Research Journal of Pharmacology and Pharmacodynamics. 2025;17(4):243-1. doi: 10.52711/2321-5836.2025.00039
Cite(Electronic):
Peeyush Kumar, Saket Singh Chandel, Neelima Yadav, Aayush Vaishnaw, Manali Rai. Red Grape Seed Extract for Memory Enhancement in Alzheimer’s Disease in Rats with Reference to the Glutamate Metabolism. Research Journal of Pharmacology and Pharmacodynamics. 2025;17(4):243-1. doi: 10.52711/2321-5836.2025.00039 Available on: https://rjppd.org/AbstractView.aspx?PID=2025-17-4-1
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