Author(s): Sanjay Jain, Mamta Singh, Rakesh Barik, Neelesh Malviya.

Email(s): Email ID Not Available

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Address: Sanjay Jain*, Mamta Singh, Rakesh Barik, Neelesh Malviya
Department of Pharmacognosy, Smriti College of Pharmaceutical Education, 4/1, Pipliya Kumar Kakkad, Mayakhedi Road, Nipania, Indore 452010, Madhya Pradesh.
*Corresponding Author

Published In:   Volume - 5,      Issue - 5,     Year - 2013


ABSTRACT:
Free radicals are fairly unstable and highly reactive substances, causing oxidation and sometimes irreversible damage to cells. This has led to an increase in intake of antioxidants. Medicinal plants are being studied extensively for their antioxidant properties. The present study was aimed to study the in-vitro antioxidant activity of aqueous and methanolic extracts of Premna integrifolia Linn roots (Verbenaceae). Both the extracts were subjected to various in-vitro antioxidant activity screening models such as DPPH, DMSO, ABTS, Nitric oxide and Iron chelation assay. Ascorbic acid was used as the standard. In all the models studied, the aqueous extract showed IC50 values of 111.009, 101.369, 99.976, 109.827, 105.239 µg/ml and the methanolic extract showed IC50 values of 98.252, 96.559, 88.163, 100.631, 95.005µg/ml for DPPH, DMSO, ABTS, Nitric oxide and Iron chelation assay, respectively.


Cite this article:
Sanjay Jain, Mamta Singh, Rakesh Barik, Neelesh Malviya. In-vitro Antioxidant activity of Premna integrifolia Linn. Roots. Research J. Pharmacology and Pharmacodynamics. 2013; 5(5): 293-296.


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