Research Journal of Pharmacology and Pharmacodynamics

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2321-5836 (Online)
0975-4407 (Print)


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Effect of Azima tetracantha Lam Leaf Extracts and Isolated Compounds on Di Methyl Benzanthracene induced Mammary Carcinoma

Author(s): B. Edwin Jose, P. Panneerselvam

Email(s): meeraharsa23@gmail.com

DOI: 10.5958/2321-5836.2019.00002.8   

Address: B. Edwin Jose1, Dr. P. Panneerselvam2
1Department of Pharmaceutical Chemistry, SSM College of Pharmacy, Erode.
2Department of Pharmaceutical Chemistry, Bharath Institute of Higher Education and Research, Chennai
*Corresponding Author

Published In:   Volume - 11,      Issue - 1,     Year - 2019

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ABSTRACT:
Objective: The objective of this study was to evaluate the effects of ethyl acetate and ethanol extract and isolated compounds II and III of Azima tetracantha LAM on 7,12-Dimethylbenzanthracene induced mammary carcinoma in Sprague–Dawley rats and to understand the expression of B-cell lymphoma-2 (Bcl-2) an anti-apoptotic protein in experimental animals tissues. Methods: The antitumor activity was accessed by the effects of ethyl acetate and ethanol extract and isolated compounds II and III of Azima tetracantha LAM on tumour weight, body weight, enzymic and non-enzymic antioxidant parameters such as thiobarbituric acid reactive substances in plasma, superoxide dismutase, glutathione peroxidase, reduced glutathione (GSH), catalase, vitamin C and vitamin E in breast tissues and serum. The extracts and isolated compounds II and III of Azima tetracantha LAM were administered orally at different doses of 200 mg/kg and dose with the standard. Western blot analysis was carried out for understanding Bcl-2 expressions. Results: Significant (p<0.01) reduction in tumor weight and gain in body weight were observed with extracts and isolated compounds II and III of Azima tetracantha LAM treatment. Enzymic and non-enzymic antioxidant levels in serum as well in breast tissues were revert back significantly (p<0.01) on extracts and isolated compounds II and III of Azima tetracantha LAM treatment. Over expression of Bcl-2 was observed in tumor control and intensities were reduced in the treatment group. Conclusion: The ethyl acetate and ethanol extract and isolated compounds II and III of Azima tetracantha LAM leaf shown anticancer activity in tested animal model.


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Cite this article:
B. Edwin Jose, P. Panneerselvam. Effect of Azima tetracantha Lam Leaf Extracts and Isolated Compounds on Di Methyl Benzanthracene induced Mammary Carcinoma. Res. J. Pharmacology and Pharmacodynamics.2019; 11(1): 05-10. doi: 10.5958/2321-5836.2019.00002.8

Cite(Electronic):
B. Edwin Jose, P. Panneerselvam. Effect of Azima tetracantha Lam Leaf Extracts and Isolated Compounds on Di Methyl Benzanthracene induced Mammary Carcinoma. Res. J. Pharmacology and Pharmacodynamics.2019; 11(1): 05-10. doi: 10.5958/2321-5836.2019.00002.8   Available on: https://rjppd.org/AbstractView.aspx?PID=2019-11-1-2


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Research Journal of Pharmacology and Pharmacodynamics (RJPPD) (ISSN: print-0975-4407, online- 2321-5836) is an international, peer-reviewed journal, devoted to Pharmacology, Pharmacodynamics and Medical Sciences. The aim of RJPPD is to increase the impact of pharmacological research both in academia and industry, with strong emphasis on quality and originality. RJPPD publishes Original research Articles, Short Communications, Review Articles in all areas of pharmacology, pharmacokinetics and human physiology.

The journal is published quaterly every year in last week of March, June, September and December (i.e. 4 issues in each calendar year).    
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