Patel VD, Patel MB, Anand IS, Patel CN Bhatt PA.
Patel VD1, Patel MB1, Anand IS1, Patel CN1 Bhatt PA2
1Department of Clinical Pharmacy, Sri Sarvajanik Pharmacy College, Mehsana– 384001
2L.M. College of Pharmacy, Ahmedabad, Gujarat, India.
Volume - 2,
Issue - 2,
Year - 2010
Toxicogenomics is a rapidly developing discipline that promises to aid scientists in understanding the molecular and cellular effects of chemicals in biological systems. This field encompasses global assessment of biological effects using technologies such as DNA microarrays or high throughput NMR and protein expression analysis .1
Toxicogemomics is the evolving science which measures the global gene expression changes in biological samples exposed to toxic agents and investigates the complex interaction between the genetic variability and environmental exposures on toxicological effects. DNA microarrays have become most popular and important method to measure the expression of mRNA level offering great potential for environmental or toxicological studies. Gene expression changes can possibly provide more sensitive, immediate, comprehensive maker of toxicity than typical toxicological endpoints such as morphological changes, carcinogenicity, and reproductive toxicity. In this regards, toxicogenomics includes genomic-scale mRNA expression (transcriptomics), cell and tissue-wide protein expression (proteomics), metabolite profiling (metabonomics), and bioinformatics. These studies can be grouped as ‘‘-omics’’ study, which could be applied to various kinds of samples and species.
Cite this article:
Patel VD, Patel MB, Anand IS, Patel CN Bhatt PA. TOXICOGENOMICS: A Review. Research J. Pharmacology and Pharmacodynamics. 2010; 2(2):131-140.