Author(s):
Akashdeep Tyagi, Preeti Chaudhary, Vipin Kumar Garg
Email(s):
akash.at009@gmail.com
DOI:
10.52711/2321-5836.2023.00005
Address:
Akashdeep Tyagi1*, Preeti Chaudhary2, Vipin Kumar Garg1
1Department of Pharmaceutical Technology, Meerut Institute of Engineering and Technology, Meerut, Uttar Pradesh, India.
2Department of Pharmacy, NCRD’s Sterling Institute of Pharmacy, Nerul, Navi Mumbai, Maharashtra, India.
*Corresponding Author
Published In:
Volume - 15,
Issue - 1,
Year - 2023
ABSTRACT:
Calotropis giganteabelongs to the Asclepiadaceae family is commonly known as Arka and Ruvi and it is found throughout India. The Aerva lanata plant is a member of Amaranthaceae family and its usually known as mountain knot grass and gorakhabooti and their role in disease cure has been documented. Different part of these plants contains numerous types of chemical constituents such as flavonoids, alkaloids, quercetin, kaempferol, sterols, cynogenic glycoside, with diverse pharmacological activities. Moreover, these plants show, anti-microbial activity, analgesic, wound healing, anti-inflammatory, hepatoprotective, anti-diuretic and anti-diabetic activities. Hence this review representsan overview of medicinal uses of Calotropis gigantea and Aerva lanata plant which is used in many formulations.
Cite this article:
Akashdeep Tyagi, Preeti Chaudhary, Vipin Kumar Garg. Pharmacological and Therapeutic Potential of Calotropis gigantea and Aerva lanata: A Review. Research Journal of Pharmacology and Pharmacodynamics 2023;15(1):19-3. doi: 10.52711/2321-5836.2023.00005
Cite(Electronic):
Akashdeep Tyagi, Preeti Chaudhary, Vipin Kumar Garg. Pharmacological and Therapeutic Potential of Calotropis gigantea and Aerva lanata: A Review. Research Journal of Pharmacology and Pharmacodynamics 2023;15(1):19-3. doi: 10.52711/2321-5836.2023.00005 Available on: https://rjppd.org/AbstractView.aspx?PID=2023-15-1-5
REFERENCES:
1. Kirtikar KR and Basu BD: Indian Medicinal Plants. International Book Distributors and Publishers, Dehradun, India, Edition 2, Vol. 1, 2008: 1607-1609
2. Nadkarni KM and Nadkarni AK: Indian Materia Medica. Popular Prakashan Pvt. Ltd, Edition 3, Vol. 1, 1976: 237-241.
3. Chaudhuri RHN: Pharmacognostic studies on the roots of Calotropis gigantea R.Br.exAit. Bull Bot Surv India 1961; 3: 171- 173.
4. Nadkarni KM. (2002) The Indian Materia Medica, Bombay Popular Prakashan: Vol I: 231-241.
5. Patel RB, Raval JD, Gandhi TP. (1998) Indian Drug. 26:224-225.
6. Chitme HR, Chandra R, Kaushik S. (2004) J. Pharm. Pharmaceutical. Sci. 7:70-75.
7. Pathak AK, Agral A. (2007) Fitoterapia, 78:40- 42
8. Kirtikar KR, Basu BD. (1980) Indian Medicinal Plants, II Edn. Vol3, Lalit Mohan Basu: Allahabad: 1606-166.
9. Srivastava SR, Keshri G, Bhargavana B, Singh C, Singh MM. Original research article: Pregnancy interceptive activity of the roots of Calotropis gigantea Linn. in rats. Contraception 2007;75:318-22
10. Sharma AK, Kharb R, Kaur R. Pharmacognostical aspects of Calotropis procera (Ait.) R. Br. International Journal of Pharma and Bio Sciences. 2011;2(3):480–8
11. Parihar G, Sharma A, Ghule S, Sharma P, Deshmukh P, Srivastava DN. Anti inflammatory effect of Calotropis procera root bark extract. Asian Journal of Pharmacy and Life Science. 2011;1(1):29–44.
12. Lhinhatrakool T, Satthivaiyakit S. 19-Norand 18, 20-Epoxy cardenolides from the leaves of Calotropis gigantea. Journal of Natural Product 2006; 69(8):1249-1251.
13. Seeka C, Satthivaiyakit S. Cytotoxic cardenolides from the leaves of Calotropis gigantea. Chemical and Pharmaceutical Bulletin 2010; 58(5):725-728.
14. Sen S, Sahu NP, Mahato SB. Flavonolglycosuides from Calotropis gigantea. Phytochemistry 1992; 31 (8):2919-2921.
15. Gupta J, Ali M. Rare Chemical Constituents from Calotropis gigantea roots. Indian Journal of Pharmaceutical Sciences 2000; 62(1):29-32.
16. Anjaneyulu V, Row LR. The triterpenoids of Calotropis gigantea Linn. Current Science 1968; 37(6):156-157.
17. Habib MR, Nikkon F, Rahman M, Haque ME, Karim MR. Isolation of Stigmasterol and βsitosterol from methanolic extract of root bark of Calotropis gigantea. Pakistan Journal of Biological Sciences 2007; 10(22):4174-4176.
18. Abraham KI, Joshi PN. Studies on proteinases from Calotropis gigantea latex. Purification and some properties of two proteinases containing carbohydrate. Biochimica et Biophysica Acta 1979; 568(1):111-119
19. Pal G, Sinha NK. Isolation, crystallization and properties of calotropin D-I and D-II from Calotropis gigantea. Archives of Biochemistry and Biophysics 1980; 202(20):321-329.
20. Pari K, Rao PJ, Devakumar C, Rastogi JN. A Novel Insect antifungal nonprotein amino acid from Calotropis gigantea. Journal of Natural Product 1998; 61(91):102-104.
21. Kumar G, Karthik L, Bhaskara Rao KV, In vitro anti-Candida activity of Calotropis gigantea against clinical isolates of Candida. Journal of Pharmacy Research 2010;3(3):539-
22. Kumar G, Karthik L, Bhaskara Rao KV, Antibacterial activity of aqueous extract of Calotropis gigantea leaves – an in vitro study. International Journal of Pharmaceutical Sciences Review and Research 2010;4(2):141-144.
23. Singh N, Jain NK, Kannojia P, Garud N, Pathak AK, Mehta SC, In vitro antioxidant activity of Calotropis gigantea hydroalcohlic leaves extract. Der Pharmacia Lettre 2010;2(3):95-
24. Pathak AK, Argal A, Analgesic activity of Calotropis gigantea flower. Fitoterapia 2007; 78(1):40-42.
25. Argal A, Pathak AK, CNS activity of Calotropis gigantea roots. J. Ethnopharmacol. 2006; 106(1):142-145.
26. Das S, Das S, Das MK, Basu SP, Evaluation of anti-inflammatory effect of Calotropis gigantea and Tridax procumbens on Wistar albino rats. J. Pharm. Sci. and Res.2009; 1(4):123-126.
27. Deshmukh PT, Fernandes J, Aarte A, Toppo E, Wound healing activity of Calotropis gigantea root bark in rats. J. Ethnopharmacol. 2009; 125(1):178-181.
28. Chitme HR, Chandra R, Kaushik S, Evaluation of antipyretic activity of Calotropis gigantea (Asclepiadaceae) in experimental animals. Phototherapy Research 2005;19(5):454-456.
29. Lodhi G, Singh HK, Pant KK, Hussain Z, Hepatoprotective effects of Calotropis gigantea extract against carbon tetrachloride induced liver injury in rats. Acta. Pharm. 2009; 59:89-96.
30. Alam MA, Habib MR, Nikkon F, Khalequzzaman M, Karim MR, Insecticidal activity of root bark of Calotropis gigantea L. against Tribolium castaneum (Herbst). World Journal of Zoology 2009;4(2):90-95.
31. Adepu A, Narala S, Ganji A, Chilvalvar S. A Review on natural plant: Aerva lanata. Int J Pharma Sci. 2013; 3:398-402.
32. Goyal M, Pareek A, Nagori BP, Sasmal D. Aerva lanata: a review on phytochemistry and pharmacological aspects. Phcog Rev 2011; 5:195-198.
33. Sharma A, Sharma SC, Vaghela JS. Phytopharmacological investigation of Aerva lanata flowers with special emphasis on diuretic activity. Pharmacogn J 2010; 2(17): 59-62
34. Soundararajan P, Mahesh R, Ramesh T, Begum VH. Effect of Aerva lanata on calcium oxalate urolithiasis in rats. Indian J Exp Biol 2006; 44(12): 981-986
35. Sharma A Tarachand, Tanwar M, Nagar N, Sharma AK. Analgesic and anti-inflammatory activity of flowers extract of Aerva lanata. Adv Pharmacol Toxicol 2011; 12(3): 13-18.
36. Chowdhury D, Sayeed A, Islam A, Shah Alam Bhuiyan M, AstaqMohal Khan GR. Antimicrobial activity and cytotoxicity of Aerva lanata. Fitoterapia 2002; 73(1): 92-94.
37. Deshmukh TA, Yadav BV, Badole SL, Bodhankar SL, Dhaneshwar SR. Antihyperglycaemic activity of alcoholic extract of Aerva lanata (L.) A.L. Juss. Ex. J.A. Schultes leaves in alloxan induced diabetic mice. J Appl Biomed 2008; 6(2): 81-87
38. Shirwaikar A, Issac D, Malini S. Effect of Aerva lanata on cisplatin and gentamycin models of acute renal failure. J Ethnopharmacol 2004; 90(1): 81-86.
39. Ramachandra YL, Shilali K, Ahmed M, Sudeep HV, Kavitha BT, Gurumurthy H, et al. Hepatoprotective properties of Boerhaaviadiffusa and Aerva lanata against carbon tetra chloride induced hepatic damage in rats. Pharmacologyonline 2011; 3: 435-441
40. Manokaran S, Jaswanth A, Sengottuvelu S, Nandhakumar J, Duraisamy R, Karthikeyan D, et al. Hepatoprotective activity of Aerva lanata Linn. against paracetamol induced hepatotoxicity in rats. Research J Pharm and Tech 2008; 1(4): 398- 400.
41. Rajesh R, Chitra K, Paarakh PM. In vitro anthelmintic activity of aerial parts of Aerva lanata Linn Juss. Int J Pharm Sci Drug Res 2010; 2(4): 269-271.
42. Singh S, Rai AK, Sharma P, Singh PA. Antidiarrhoeal activity of Aerva lanata in experimentally induced diarrhoea in rats. Pharmacologyonline 2011; 2:921-928
43. India biodiversity. http://indiabiodiversity.org/species/show/32892. 8 Sep, 2014.
44. Nagaratna A, Prakash LH, Harini A. A pharmacological review on Gorakha ganja (Aerva lanata (Linn) Juss. Ex. Schult). Journal of Pharmacognosy and Phytochemistry. 2014; 3:253-257.
45. ITISReport.http://www.itis.gov/servlet/SingleRpt/SingleRpt?search_topic=TSN and search_value=506581. 8 September, 2014.
46. GBIF Organization. http://www.gbif.org/species/ 3085014/classification. 8 September, 2014.
47. NCBI Resources. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3263055/ 8 September, 2014
48. Chunekar KC, Pandey GS. Editor, Bhavapraksha Nighantu of Bhavamishra. Chaukhambha Bharathi Academy, Varanasi, 2010, 103-104
49. Kirtikar KR, Basu BD. Indian Medicinal plants. Edn 2, Vol 3, International Book Distributors, Dehradun, 2065.
50. Guptha AK, Neeraj T, Sharma M. Quality standards of Indian Medicinal Plants. Vol 3, ICMR, New Delhi, 2005, 9-19.
51. Manoj Goyal, Anil Pareek, B.P Nagori and D. Samal, Aerva lanata: a review on phytochemistry and pharmacological aspects, Pharmacognosy Review 2011 July Dec;5,195-198
52. Arunaadepu, Sagarnarala, Ashokganji and Sapnilchilvalvar, A review on natural plant: aerva lanata, International Journal of Pharmascience, 3,2013,398-402
53. Dr. Gopi Krishnamaddikera, Benefits of Aerva lanata
54. Mandallbitachandras, Sastrym. S, Chemical constituents of aerva lanata, Fitoterapia,61,1990,188sta
55. Vetrichelvan T, Jegadeesan M, Senthil Palaniappan M, Murali NP, Sasikumar K. Diuretic and antiinflammatory activities of aervaIanata in rats. Indian J Pharm Sci 2000;62:300-2.
56. Soundararajan P, Mahesh R, Ramesh T, Begum VH. Effect of Aerva lanata on calcium oxalate urolithiasis in rats. Indian J Exp Biol 2006;44:981-6
57. Vetrichelvan T, Jegadeesan M, Senthil P, Murali NP, Sasikumar K. Diuretic and Anti-inflammatory activity of Aerva lanata in rats. Indian Journal of Pharmaceutical Sciences 2000, 300-302.
58. Rajesh R, Chitra K, Paarakh PM. Anti-diabetic and histopathological studies of aerial parts of Aerva lanata linnjuss on streptozotocin induced diabetic rats. World Journal of Pharmacy and Pharmaceutical Sciences 2014; 3(8): 455-471.
59. Nevin KG, Vijayammal PL. Effect of Aerva lanata against hepatotoxicity of carbon tetrachloride in rats. Environ Toxicol Pharmacol 2005; 20:471-7.