Author(s):
Kranti Sahu, Deepak Kumar Basedia, Balkrishna Dubey, Sunil Kumar Shah, Sandra Goutam
Email(s):
cology449@gmail.com
DOI:
10.52711/2321-5836.2025.00004 
Address:
Kranti Sahu1, Deepak Kumar Basedia1, Balkrishna Dubey1, Sunil Kumar Shah2, Sandra Goutam1
1Technocrats Institute of Technology – Pharmacy, Bhopal, MP.
2TIT College of Pharmacy, Bhopal, MP.
*Corresponding Author
Published In:
Volume - 17,
Issue - 1,
Year - 2025
ABSTRACT:
Introduction: Ulcer is erosion on the skin or on the mucous membrane specified by outward inflamed dead tissue. The word ulcer is derived from Latin word “ulcus” (genitive: ulceris) which stands for sore, wound or an ulcer. The erosions are most commonly seen on gastric or duodenal mucosa and are referred to as peptic ulcer. Peptic ulcers are the areas of degeneration and necrosis of gastro-intestinal mucosa which is exposed to acid and pepsin secretion. The primary aim of this research is to systematically investigate the antiulcer activity of the hydroalcoholic fruit extract of Catunaregam spinosa. This involves a comprehensive examination of the potential therapeutic effects that the extract may possess in mitigating ulcer formation. Catunaregam spinosa linn. (Thunb.) belongs to the family Rubiaceae. The genus Catunaregum (XeramphisRafin.) Consist of about10species, out of which two are in India. In Ayurveda it is known as madanaphala. Conclusion: The study investigated the hydroalcoholic extract of Catunaregam spinosa linn.for its potential anti-ulcerogenic effects and its influence on various gastric parameters in rats with ethanol- induced ulcers. The extraction process yielded 7.63% from hydroalcoholic solvent, significantly higher than the 1.02% yield from pet ether extraction. Phytochemical screening of the hydroalcoholic extract identified the presence of alkaloids, glycosides, flavonoids, proteins, saponins, and diterpenes, while phenols, carbohydrates, and tannins were absent.
Cite this article:
Kranti Sahu, Deepak Kumar Basedia, Balkrishna Dubey, Sunil Kumar Shah, Sandra Goutam. Pharmacological and Phytochemical Investigation of Ulcer Protective property Catunaregam spinosa Linn. Research Journal of Pharmacology and Pharmacodynamics. 2025; 17(1):19-4. doi: 10.52711/2321-5836.2025.00004
Cite(Electronic):
Kranti Sahu, Deepak Kumar Basedia, Balkrishna Dubey, Sunil Kumar Shah, Sandra Goutam. Pharmacological and Phytochemical Investigation of Ulcer Protective property Catunaregam spinosa Linn. Research Journal of Pharmacology and Pharmacodynamics. 2025; 17(1):19-4. doi: 10.52711/2321-5836.2025.00004 Available on: https://rjppd.org/AbstractView.aspx?PID=2025-17-1-4
REFERENCES:
1. R. Kumar. A review on medicinal plants for peptic ulcer. Scholar Research Library. Der Pharmacia Lettre. 2011; 3(3): 414–420.
2. G. Patel and S. Jain. Antiulcer activity of Neriutnindicumin rats. Research Journal of Pharmacology. 2010; 4(3): 66–68.
3. K. M. Nadkarni's. Indian Materia Medica. Volume 1, pp. 9-10, Popular Prakashan, Mumbai, India,1976.
4. K. H. Omayma, M. Y. Mohamed, and M. Elnaa. Possible protective effect of Gum Arabic on experimentally induced gastric ulcer in adult male albino rats: a histopathological and immunohistochemical study. Egyptian Journal of Histology. 2011; 34: 546–553.
5. M. A. Abd El-Mawla and H. E. H. Osman. Effects of Gum acacia aqueous extract on the histology of the intestine and enzymes of both the intestine and the pancreas of albino rats treated with Meloxicam. Pharmacognosy Research. 2011; 3(2): 114– 121.
6. T. KumariSubitha, M. Ayyanar, M. Udayakumar, and T. Sekar, Ethnomedicinalplats used by Kanitribals in Pechiparai forests of Southern Western Ghats, Tamilnadu, India. International Research Journal Plant Science. 2011; 2(12): 349– 354.
7. J. R. Ilavarasan, S. Monideen, and M. Vijayalakshmi. Antiulcer activity of Aeglemarmelos. Ancient Science of Life. 2002; 21(4): 23–26.
8. R. K. Goel, R. N. Maiti, M. Manickam, and A. B. Ray.Antiulcer activity of naturally occurring pyrano-coumarin and iso-coumarins and their effect on prostanoid synthesis using human colonic mucosa. Indian Journal of Experimental Biology. 1997; 35(10): 1080–1083.
9. M. Azamthulla, M. Asad, and V. S. Prasad. Antiulcer activity of Allium sativumbulb juice in rats. Saudi Pharmaceutical Journal. 2009; 17(1): 70–77.
10. S. K. Borra, R. K. Lagisetty, and G. R. Mallela. Anti-ulcer effect of Aloe vera in non-steroidal anti-inflammatory drug induced peptic ulcers in rats. African Journal of Pharmacy and Pharmacology. 2011; 5(16): 1867–1871.
11. T. S. Mohamed Saleem, R. Pradeep Kumar, N. Priyanka, M. Madhuri, V. Sravanti, and K. Sarala. Anti-ulcerogenic effect of aqueous extract of Annonasquamosa (Linn). International Journal of Research in Phytochemistry and Pharmacology. 2012; 2(3): 157–159.
12. M. C. Divakar, S. B. Rao, G. R. N. Nair, and A. Hisham. The role of fatty acids on the ulcer healing property of the nimbidin fraction of the neem oil. Journal of Medicinal and Aromatic Plants Science. 2001; 23(3): 404–408.
13. N. R. Pillai and G. Santhakumari. Toxicity studies on nimbidin, a potential anti-ulcer drug. Planta Medica. 1984; 50(2): 146–148.
14. Y. R. Kumar and G. P. Rajani. Analgesic and anti-ulcer activities of ethanol and aqueous extracts of root of Bauhinia variegate Linn. International Journal of Pharmacology. 2011; 7(5): 616–622.
15. K. Kumar, K. Mruthunjaya, S. Kumar, and R. Mythreyi. Anti-ulcer activity of ethanol extract of the stem bark of Careyaarborea Roxb. International Current Pharmaceutical Journal. 2013; 2(3): 78–82.
16. R. Kottaimuthu. Ethnobotany of the Valaiyans of Karandamalai, Dindigul District, Tamil Nadu, India. Ethnobotanical Leaflets. 2008; 12:195–203.
17. M. Indran, A. A. Mahmood, and V. R. Kuppusamy. Protective effect of Carica papaya L leaf extract against alcohol induced acute gastric damage and blood oxidative stress in rats. West Indian Medical Journal. 2008; 57(4): 323–326.
18. J. Drenth, J. N. Jansonius, R. Koekoek, and B. G. Wolthers. The structure of papain. Advances in Protein Chemistry. 1971; 25: 79–115.
19. M. Gregory, B. Divya, R. A. Mary, M. M. HipolithViji, V. K. Kalaichelvan, and V. Palanivel. Anti-ulcer activity of Ficusreligiosaleaf ethanolic extract. Asian Pacific Journal of Tropical Biomedicine. 2013; 3(7): 554–556.
20. S. Saha and G. Goswami. Study of anti-ulcer activity of FicusreligiosaL. on experimentally induced gastric ulcers in rats. Asian Pacific Journal of Tropical Medicine. 2010; 3(10): 791–793.
21. Delma ET, Ouedraogo M, Ouedraogo AS, Nikiema AW, AbdoulayeGambo M, RamdeN, Youl EN, Sanou-Lamien A, Lompo OM, Guissou PI. Antiulcer Effect of Aqueous Ethanolic Extracts of Pseudocedrelakotschyi (Schweinf) Harms (Meliaceae) and Ximeniaamericana L. (Olacaceae). Journal of Experimental Pharmacology. 2023 Dec31: 231-40.
22. Seitimova GA, Shokan AK, Tolstikova TG, ZhukovaNA, Korulkin DY, Kudrina NO, Litvinenko YA, Meduntseva ND, Terletskaya NV, Kulmanov TE. Antiulcer Activity of Anthraquinone Flavonoid Complex of Rumextianschanicus Losinsk. Molecules. 2023 Mar3; 28(5):2347.
23. Shoukry SM, El-Hawiet A, El-Mezayen NS, Ghazy NM, Ibrahim RS. Unraveling putative antiulcer phytoconstituents against Helicobacter pylori urease and human H+/K+-ATPase from Jacaranda mimosifolia using UPLC-MS/MS coupled to chemometrics and molecular docking. Microchemical Journal. 2023 Jun 1; 189:108550.
24. Sweilam SH, Abdel Bar FM, Foudah AI, Alqarni MH, El-Gindi OD, El-Sherei MM, Abdel-Sattar E. Phytochemical Investigation, Antiulcer, Cyclooxygenase-2, and 15- Lipoxygenase Inhibitory Activities of Echinopserinaceus Kit Tan.Separations. 2023 Jan21; 10(2):76.
25. Abdoulrahman K. Anti-ulcer effect of Ranunculus millefoliatus on absolute alcohol-induced stomach ulceration. Saudi Journal of Biological Sciences. 2023 Jun 16:103711.
26. Shukla M, Tiware SA, Desai SR, Kumbhar ST, Khan MS, Mavai Y, Dharmamoorthy G, Devhare LD. Pharmacological Evaluation of GloriosaSuperba Linn Flower Extract for Antiulcer Activity.Journal of Survey in Fisheries Sciences. 2023 Jun18:463-70.
27. Kumar R, Singh A, Painuly N. Investigation of in-vitro anti-oxidant and anti-ulcer activity of polyherbal medicinal plants. Journal of Pharmaceutical Negative Results. 2022 Oct 5: 2077-88.
28. Ajaib M, Ishtiaq S, Ishtiaq M, Maqbool M, Bhatti KH, Khan A, Afreen A, Hussain T, Sardar T, Gul A, Azeem M. Analysis of antidiabetic, antiulcer and analgesic potential of traditional ethnomedicinal plant Emex spinosa (L.) Campd. from Azad Jammu and Kashmir. Plos one. 2022 Oct 13; 17(10): e0274706.
29. Andargie Y, Sisay W, Molla M, Norahun A, Singh P. Evaluation of the antiulcer activity of methanolic extract and solvent fractions of the leaves of Calpurnia aurea (Ait.) Benth. (Fabaceae) in rats. Evidence-Based Complementary and Alternative Medicine. 2022 Jun29; 2022.
30. Khursheed A, Ahmad S, Khan KU, Tousif MI, Aati HY, Ovatlarnporn C, Rao H, Khurshid U, Ghalloo BA, Tabassum S, Basit A. Efficacy of Phytochemicals Derived from Roots of Rondeletiaodorata as Antioxidant, Antiulcer, Diuretic, SkinBrightening and Hemolytic Agents A Comprehensive Biochemical and In Silico Study. Molecules. 2022 Jun 30; 27(13): 4204.
31. Sisay W, Andargie Y, Molla M, Norahun A. Hydromethanolic crude extract of the leaf of Urticasimensis Hochst. ex. A. Rich. (Urticaceae) acquires appreciable antiulcer effect: validation for in vivo antiulcer activity. Evidence-based Complementary and Alternative Medicine. 2021 Jul21; 2021.
32. Boakye-Yiadom M, Kumadoh D, Adase E, Woode E. Medicinal plants with prospective benefits in the management of peptic ulcer diseases in Ghana.Bio Med Research International. 2021May6; 2021.
33. Ukwuani-Kwaja AN, Sani I, Kindzeka LS, Gudu GJ. Ethnobotanical survey of medicinal plants used as antiulcer in Gwandu Emirate, Kebbi State, Nigeria. Hist. Philos. Med. 2021; 3(3): e15.