Rabari HA, Pandya SS, Vidyasagar G, Gajra B, Upadhyay NP.
Rabari H.A.1*, Pandya S.S.2, Vidyasagar G.1, Gajra B.1 and Upadhyay N.P.1
1Veerayatan Institute of Pharmacy, Jakhania, Bhuj-Mandvi Road, Kachchh, Gujarat, India-370460.
2Pharmacy College, Rampura, Post-Kakanpur, Tal.-Godhra, Panchmahal (District), Gujarat, India-389713.
Volume - 2,
Issue - 3,
Year - 2010
The methanolic and aqueous extract of Melhania futteyporensis leaves, at the doses of 200 and 400 mg/kg body weight, were tested for anti-inflammatory and wound healing activity. The carrageenan induced rat paw edema model was selected to evaluate anti-inflammatory activity. The percentage inhibition of paw edema by the extracts was found to be significant at the dose of 400 mg/kg body weight, compared to control. The exhibited anti-inflammatory activity of Melhania futteyporensis was comparable with the standard drug aspirin. The wound healing activity was evaluated by using excision wound model of albino wistar rats. The percentage of wound contraction by both the methanolic and aqueous extracts was found to be significant at the dose of 400 mg/kg body weight. The exhibited wound healing activity was comparable with the standard drug povidone iodine ointment. The extract treated wounds were found to epithelize faster as compared to controls.
Cite this article:
Rabari HA, Pandya SS, Vidyasagar G, Gajra B, Upadhyay NP. Anti-inflammatory and Wound healing activity of Melhania futteyporensis Munro EX Masters Leaf. Research J. Pharmacology and Pharmacodynamics. 2010; 2(3): 233-238.