Author(s): Vadivelan R, Umasankar P, Dipanjan Mandal, Shanish A, Dhanabal S.P, Elango K.

Email(s): rv_sofia@rediffmail.com

DOI: Not Available

Address: Vadivelan R, Umasankar P, Dipanjan Mandal, Shanish A, Dhanabal S.P and Elango K
Department of Pharmacology, J.S.S College of Pharmacy, (Off campus of JSS University, Mysore) Ooty, Niligiris-643001
*Corresponding Author

Published In:   Volume - 2,      Issue - 5,     Year - 2010


ABSTRACT:
Diabetic nephropathy is one of the main causes of renal end-stage disease. Morphologically, the development of diabetic nephropathy is characterized by progressive thickening of the glomerular basement membrane and by expansion of the mesangial matrix which correlates to glomerular filtration function. Hyperglycemia generates more reactive oxygen species and also attenuates antioxidative mechanisms through glycation of the scavenging enzymes. Therefore, oxidative stress has been considered to be a common pathogenetic factor of the diabetic complications including nephropathy. A causal relationship between oxidative stress and diabetic nephropathy has been established by observations that (1) Lipid peroxides and 8-hydroxydeoxyguanosine, indices of oxidative tissue injury, were increased in the kidneys of diabetic rats with albuminuria.(2) High glucose directly increases oxidative stress in glomerular mesangial cells, a target cell of diabetic nephropathy.(3) oxidative stress induces mRNA expression of TGF-b1(transforming growth factor beta1) and fibronectin which are the genes implicated in diabetic glomerular injury, and (4) Inhibition of oxidative stress ameliorates all the manifestations associated with diabetic nephropathy.


Cite this article:
Vadivelan R, Umasankar P, Dipanjan Mandal, Shanish A, Dhanabal SP, Elango K.Oxidative Stress Induced Diabetic Nephropathy. Research J. Pharmacology and Pharmacodynamics. 2010; 2(5): 321-323.

Cite(Electronic):
Vadivelan R, Umasankar P, Dipanjan Mandal, Shanish A, Dhanabal SP, Elango K.Oxidative Stress Induced Diabetic Nephropathy. Research J. Pharmacology and Pharmacodynamics. 2010; 2(5): 321-323.   Available on: https://rjppd.org/AbstractView.aspx?PID=2010-2-5-12


Recomonded Articles:

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, Das, GC Nanda.

DOI: Not Available         Access: Open Access Read More

Author(s): Gautam Kumar, Ravi Kumar, Harshit Rana

DOI: 10.52711/2321-5836.2023.00007         Access: Open Access Read More

Author(s): Lubna Azmi, Shyam Sundar Gupta, Ila Shukla, Padam Kant, O. P. Sidhu, Ch. V. Rao

DOI: 10.5958/2321-5836.2017.00001.5         Access: Open Access Read More

Author(s): Kanase KG, Shinde NV, Bharti DK, Undale VR, Bhosale AV.

DOI: Not Available         Access: Open Access Read More

Author(s): Sathyaseelan Thennarasan, Subbiah Murugesan, Vajiravelu Sivamurugan

DOI: 10.5958/2321-5836.2017.00011.8         Access: Open Access Read More

Author(s): AV Jaydeokar, DD Bandawane, SS Nipate , PD. Chaudhari.

DOI: Not Available         Access: Open Access Read More

Author(s): SM Bhanushali, KM Modh, IS Anand, CN Patel , JB Dave.

DOI: Not Available         Access: Open Access Read More

Author(s): Suryawanshi CP, Patil VR, Chaudhari RY, Kale MK, Firake SD, Pimprikar RB, Patil MD, Yeshwante SB, Saindanem DS.

DOI: Not Available         Access: Open Access Read More

Author(s): SC Shivhare, Arjun O Patidar, KG Malviya, K Venkatesh , Kuldeep Rathod.

DOI: Not Available         Access: Open Access Read More

Author(s): Jhakeshwar Prasad, Ashish Kumar Netam, Ritika Singh, Manisha Sahu, Trilochan Satapathy, S. Prakash Rao, Purnima Baghel, Mahendra Kumar Sahu

DOI: 10.5958/2321-5836.2019.00009.0         Access: Open Access Read More

Author(s): P Muthukumaran, S Salomi , R Umamaheshwari.

DOI: Not Available         Access: Open Access Read More

Author(s): Chirag K Patel, B Panigrahi , R Badmanaban, CN Patel.

DOI: Not Available         Access: Open Access Read More

Author(s): PA Pathade, YS Ahire, VA Bairagi , DR Abhang.

DOI: Not Available         Access: Open Access Read More

Author(s): Amit Roy, Ram Kumar Sahu, Pushpa Prasad.

DOI: Not Available         Access: Open Access Read More

Author(s): Rupa Bhattacharya, Samira R. Khan

DOI: 10.5958/2321-5836.2020.00015.4         Access: Open Access Read More

Author(s): Karnakumar V Biradar, Chandrashekhar B Patil, Basavaraj V Chivde, MH Malipatil, Sanjivkumar D Biradar.

DOI: Not Available         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 

Journal Policies & Information




Recent Articles




Tags