Research Journal of Pharmacology and Pharmacodynamics

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2321-5836 (Online)
0975-4407 (Print)


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Review on Progeria: A Rare Genetic Premature Aging Disorder

Author(s): Rupa Bhattacharya, Samira R. Khan

Email(s): rup22990@gmail.com , ksamira18@gmail.com

DOI: 10.5958/2321-5836.2020.00015.4   

Address: Rupa Bhattacharya, Samira R. Khan
Maharashtra Institute of Pharmacy (B.Pharm) Betala, Bramhapuri.
*Corresponding Author

Published In:   Volume - 12,      Issue - 2,     Year - 2020

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ABSTRACT:
Progeria also known as “Hutchinson Gilford Progeria Syndrome”, was reported by Jonathan Hutchinson in 1886 and further described by “Hasting Gilford” in 1904. It is rare genetic disorder characterized by dramatic phenotype premature aging and accelerated cardiovascular disease.It is mostly caused by a de novo point mutation in the lamin A gene that activate a cryptic slice donor site ,producing a truncated mutant protein termed “progerin”.Clinical manifestations are evident by the first and second year of solely on physical symptoms but today the progeria research foundation has established progeria cell and tissue banks to assist in further diagnostic process.Treatment include aspirin which helps prevent the atherithrombotic events ,stroke and heart attack by hindering platelet aggregation.


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Cite this article:
Rupa Bhattacharya, Samira R. Khan. Review on Progeria: A Rare Genetic Premature Aging Disorder. Res. J. Pharmacology and Pharmacodynamics.2020; 12(2): 73-82. doi: 10.5958/2321-5836.2020.00015.4

Cite(Electronic):
Rupa Bhattacharya, Samira R. Khan. Review on Progeria: A Rare Genetic Premature Aging Disorder. Res. J. Pharmacology and Pharmacodynamics.2020; 12(2): 73-82. doi: 10.5958/2321-5836.2020.00015.4   Available on: https://rjppd.org/AbstractView.aspx?PID=2020-12-2-6


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Research Journal of Pharmacology and Pharmacodynamics (RJPPD) (ISSN: print-0975-4407, online- 2321-5836) is an international, peer-reviewed journal, devoted to Pharmacology, Pharmacodynamics and Medical Sciences. The aim of RJPPD is to increase the impact of pharmacological research both in academia and industry, with strong emphasis on quality and originality. RJPPD publishes Original research Articles, Short Communications, Review Articles in all areas of pharmacology, pharmacokinetics and human physiology.

The journal is published quaterly every year in last week of March, June, September and December (i.e. 4 issues in each calendar year).    
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