Sex-based Differences in the Pharmacokinetic and Pharmacodynamic activity of different Drugs

Rohan Pal; Ritam Ghosh; Banibrata Acharyya; Rajat Subhra Saha; Sudipta Dey; Arpita Nandy; Arin Bhattacharjee

doi:10.52711/2321-5836.2023.00032

Research Journal of Pharmacology and Pharmacodynamics

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2321-5836 (Online)
0975-4407 (Print)

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Sex-based Differences in the Pharmacokinetic and Pharmacodynamic activity of different Drugs

Author(s): Rohan Pal, Ritam Ghosh, Banibrata Acharyya, Rajat Subhra Saha, Sudipta Dey, Arpita Nandy, Arin Bhattacharjee

Email(s): pal.rohan1995@gmail.com

DOI: 10.52711/2321-5836.2023.00032

Address: Rohan Pal1*, Ritam Ghosh2, Banibrata Acharyya2, Rajat Subhra Saha2, Sudipta Dey2, Arpita Nandy2, Arin Bhattacharjee3
1Assistant Professor, Department of Pharmacology, Global College of Pharmaceutical Technology, Krishnanagar, Nadia, West Bengal 741102, India.
2Department of Pharmacology, Global College of Pharmaceutical Technology, Krishnanagar, Nadia, West Bengal 741102, India.
3Principal, Global College of Pharmaceutical Technology, Krishnanagar, Nadia, West Bengal 741102, India.
*Corresponding Author

Published In: Volume - 15, Issue - 4, Year - 2023

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ABSTRACT:
The precise effects of sex on the effects of various drugs are still unknown, even though sex-specific variations in various medications are well documented. It is not uncommon for women and men to react differently to different medications due to differences in their body composition, physiology, and drug pharmacokinetics (A, D, M, E), as well as pharmacodynamics. These differences include hormonal effects during the menstrual cycle, pregnancy, and menopause. The underrepresentation of women in clinical trials, which is a significant obstacle to the optimisation of medicines for women of all ages, directly contributes to the underuse of evidence-based medications. As an added bonus, women experience greater side effects from drugs than men do. Thus, the majority of trials that were performed on middle-aged men were used to develop current recommendations for disease prevention, diagnosis, and medical treatment. To improve the safety and effectiveness of different medications as well as to create appropriate, individualized treatment plans for both males and females, it is greatly essential to understand the sex-related differences. In order to better understand the gender-based variations in the efficacy and safety of various medicines, this review gives a brief summary of the pharmacokinetics and pharmacodynamics of many drugs, organized by gender.

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Cite this article:
Rohan Pal, Ritam Ghosh, Banibrata Acharyya, Rajat Subhra Saha, Sudipta Dey, Arpita Nandy, Arin Bhattacharjee. Sex-based Differences in the Pharmacokinetic and Pharmacodynamic activity of different Drugs. Research Journal of Pharmacology and Pharmacodynamics.2023;15(4):179-5. doi: 10.52711/2321-5836.2023.00032

Cite(Electronic):
Rohan Pal, Ritam Ghosh, Banibrata Acharyya, Rajat Subhra Saha, Sudipta Dey, Arpita Nandy, Arin Bhattacharjee. Sex-based Differences in the Pharmacokinetic and Pharmacodynamic activity of different Drugs. Research Journal of Pharmacology and Pharmacodynamics.2023;15(4):179-5. doi: 10.52711/2321-5836.2023.00032 Available on: https://rjppd.org/AbstractView.aspx?PID=2023-15-4-6

REFERENCES:
1.   Patrick, K. S. Goodman and Gilman’s The Pharmacological Basis of Therapeutics. 10th Edition Edited by J. G. Hardman, L. E. Limbird, and A. G. Gilman. McGraw Hill, New York. 2001. Xxvii + 2148 Pp. 21 × 26 Cm. ISBN 0-07-1354469-7. $125.00. J. Med. Chem. 2002; 45 (6): 1392–1393. https://doi.org/10.1021/jm020026w.
2.   Bren, L. Does Sex Make a Difference? FDA Consum.2005; 39(4): 10–15.
3.   Schwartz, J. B. The Influence of Sex on Pharmacokinetics. Clin. Pharmacokinet. 2003; 42(2): 107–121. https://doi.org/10.2165/00003088-200342020-00001.
4.   Fletcher, C. V.; Acosta, E. P.; Strykowski, J. M. Gender Differences in Human Pharmacokinetics and Pharmacodynamics. J. Adolesc. Health. 1994; 15(8): 619–629. https://doi.org/10.1016/S1054-139X(94)90628-9.
5.   Kimura, T.; Higaki, K. Gastrointestinal Transit and Drug Absorption. Biol. Pharm. Bull. 2002; 25(2): 149–164. https://doi.org/10.1248/BPB.25.149.
6.   Fleisher, D.; Li, C.; Zhou, Y.; Pao, L. H.; Karim, A. Drug, Meal and Formulation Interactions Influencing Drug Absorption after Oral Administration. Clinical Implications. Clin. Pharmacokinet. 1999; 36(3): 233–254. https://doi.org/10.2165/00003088-199936030-00004.
7.   Mojaverian, P.; Rocci, M. L.; Conner, D. P.; Abrams, W. B.; Vlasses, P. H. Effect of Food on the Absorption of Enteric-Coated Aspirin: Correlation with Gastric Residence Time. Clin. Pharmacol. Ther. 1987; 41(1): 11–17. https://doi.org/10.1038/CLPT.1987.3.
8.   Gandhi, M.; Aweeka, F.; Greenblatt, R. M.; Blaschke, T. F. Sex Differences in Pharmacokinetics and Pharmacodynamics. Annu. Rev. Pharmacol. Toxicol. 2004; 44: 499–523. https://doi.org/10.1146/ANNUREV.PHARMTOX.44.101802.121453.
9.   Baraona, E.; Abittan, C. S.; Dohmen, K.; Moretti, M.; Pozzato, G.; Chayes, Z. W.; Schaefer, C.; Lieber, C. S. Gender Differences in Pharmacokinetics of Alcohol. Alcohol. Clin. Exp. Res. 2001; 25(4): 502–507. https://doi.org/10.1111/J.1530-0277.2001.TB02242.X.
10.   Jochmann, N.; Stangl, K.; Garbe, E.; Baumann, G.; Stangl, V. Female-Specific Aspects in the Pharmacotherapy of Chronic Cardiovascular Diseases. Eur. Heart J. 2005; 26(16): 1585–1595. https://doi.org/10.1093/EURHEARTJ/EHI397.
11.   Schwartz, J. B. The Current State of Knowledge on Age, Sex, and Their Interactions on Clinical Pharmacology. Clin. Pharmacol. Ther. 2007; 82(1): 87–96. https://doi.org/10.1038/SJ.CLPT.6100226.
12.   Ochs, H. R.; Greenblatt, D. J.; Divoll, M.; Abernethy, D. R.; Feyerabend, H.; Dengler, H. J. Diazepam Kinetics in Relation to Age and Sex. Pharmacology. 1981; 23(1): 24–30. https://doi.org/10.1159/000137524.
13.   Xue, F. S.; Tong, S. Y.; Liao, X.; Liu, J. H.; An, G.; Luo, L. K. Dose-Response and Time Course of Effect of Rocuronium in Male and Female Anesthetized Patients. Anesth. Analg. 1997; 85(3): 667–671. https://doi.org/10.1097/00000539-199709000-00033.
14.   Wedel, M.; Pieters, J. E.; Pikaar, N. A.; Ockhuizen, T. Application of a Three-Compartment Model to a Study of the Effects of Sex, Alcohol Dose and Concentration, Exercise and Food Consumption on the Pharmacokinetics of Ethanol in Healthy Volunteers. Alcohol Alcohol. 1991; 26(3): 329–336. https://doi.org/10.1093/OXFORDJOURNALS.ALCALC.A045119
15.   Sowinski, K. M.; Abel, S. R.; Clark, W. R.; Mueller, B. A. Effect of Gender on the Pharmacokinetics of Ofloxacin. Pharmacotherapy. 1999; 19(4): 442–446. https://doi.org/10.1592/PHCO.19.6.442.31044.
16.   Whitley, H. P.; Fermo, J. D.; Chumney, E. C. G.; Brzezinski, W. A. Effect of Patient-Specific Factors on Weekly Warfarin Dose. Ther. Clin. Risk Manag. 2007; 3(3):499.
17.   Anderson, G. D. Sex and Racial Differences in Pharmacological Response: Where Is the Evidence? Pharmacogenetics, Pharmacokinetics, and Pharmacodynamics. J. Womens. Health (Larchmt). 2005; 14(1): 19–29. https://doi.org/10.1089/JWH.2005.14.19.
18.   Garcia, D.; Regan, S.; Crowther, M.; Hughes, R. A.; Hylek, E. M. Warfarin Maintenance Dosing Patterns in Clinical Practice: Implications for Safer Anticoagulation in the Elderly Population. Chest2005;127(6):2049–2056. https://doi.org/10.1378/CHEST.127.6.2049.
19.   Dobbs, N. A.; Twelves, C. J.; Gillies, H.; James, C. A.; Harper, P. G.; Rubens, R. D. Gender Affects Doxorubicin Pharmacokinetics in Patients with Normal Liver Biochemistry. Cancer Chemother. Pharmacol. 1995; 36(6): 473–476. https://doi.org/10.1007/BF00685796.
20.   Walter Bock, K.; Schrenk, D.; Forster, A.; Griese, E. U.; Mörike, K.; Brockmeier, D.; Eichelbaum, M. The Influence of Environmental and Genetic Factors on CYP2D6, CYP1A2 and UDP-Glucuronosyltransferases in Man Using Sparteine, Caffeine, and Paracetamol as Probes. Pharmacogenetics. 1994; 4(4): 209–218. https://doi.org/10.1097/00008571-199408000-00005.
21.   Yukawa, E.; Honda, T.; Ohdo, S.; Higuchi, S.; Aoyama, T. Population-Based Investigation of Relative Clearance of Digoxin in Japanese Patients by Multiple Trough Screen Analysis: An Update. J. Clin. Pharmacol.1997;37(2):92–100. https://doi.org/10.1002/J.1552-4604.1997.TB04766.X.
22.   Walle, T.; Walle, U. K.; Cowart, T. D.; Conradi, E. C. Pathway-Selective Sex Differences in the Metabolic Clearance of Propranolol in Human Subjects. Clin. Pharmacol. Ther. 1989; 46(3): 257–263. https://doi.org/10.1038/CLPT.1989.136.
23.   Anderson, G. D. Gender Differences in Pharmacological Response. Int. Rev. Neurobiol. 2008; 83: 1–10. https://doi.org/10.1016/S0074-7742(08)00001-9.
24.   Campesi, I.; Fois, M.; Franconi, F. Sex and Gender Aspects in Anesthetics and Pain Medication. Handb. Exp. Pharmacol. 2012; 214(214): 265–278. https://doi.org/10.1007/978-3-642-30726-3_13.
25.   Kokras, N.; Dalla, C.; Papadopoulou-Daifoti, Z. Sex Differences in Pharmacokinetics of Antidepressants. Expert Opin. Drug Metab. Toxicol. 2011; 7(2): 213–226. https://doi.org/10.1517/17425255.2011.544250.
26.   Seeman, M. V. Gender Differences in the Prescribing of Antipsychotic Drugs. Am. J. Psychiatry. 2004; 161(8): 1324–1333. https://doi.org/10.1176/APPI.AJP.161.8.1324.
27.   Buchanan, M. R.; Rischke, J. A.; Butt, R.; Turpie, A. G. G.; Hirsh, J.; Rosenfeld, J. The Sex-Related Differences in Aspirin Pharmacokinetics in Rabbits and Man and Its Relationship to Antiplatelet Effects. Thromb. Res. 1983; 29(2): 125–139. https://doi.org/10.1016/0049-3848(83)90134-2.
28.   Ho, P.; Triggs, E.; Bourne, D.; Heazlewood, V. The Effects of Age and Sex on the Disposition of Acetylsalicylic Acid and Its Metabolites. Br. J. Clin. Pharmacol. 1985; 19(5): 675–684. https://doi.org/10.1111/J.1365-2125.1985.TB02695.X.
29.   Tamargo, J.; Rosano, G.; Walther, T.; Duarte, J.; Niessner, A.; Kaski, J. C.; Ceconi, C.; Drexel, H.; Kjeldsen, K.; Savarese, G.; Torp-Pedersen, C.; Atar, D.; Lewis, B. S.; Agewall, S. Gender Differences in the Effects of Cardiovascular Drugs. Eur. Hear. J. - Cardiovasc. Pharmacother. 2017; 3(3): 163–182. https://doi.org/10.1093/EHJCVP/PVW042.
30.   Sheykh, M.; Ostadrahimi, P.; Havasian, M. R.; Rostami-Estabragh, K.; Mahmoodi, Z. Evaluation of Gender Differences in the Prevalence of Coronary Risk Factors in Patients with Acute Intractable Syndrome Hospitalized in CCU of Amir-Almomenin Hospital, Zabol. Res. J. Pharm. Technol. 2017; 10(9): 2883–2886. https://doi.org/10.5958/0974-360X.2017.00509.1.
31.   Luzier, A. B.; Killian, A.; Wilton, J. H.; Wilson, M. F.; Forrest, A.; Kazierad, D. J. Gender-Related Effects on Metoprolol Pharmacokinetics and Pharmacodynamics in Healthy Volunteers. Clin. Pharmacol. Ther. 1999; 66(6): 594–601. https://doi.org/10.1053/CP.1999.V66.103400001.
32.   Krecic-Shepard, M. E.; Barnas, C. R.; Slimko, J.; Jones, M. P.; Schwartz, J. B. Gender-Specific Effects on Verapamil Pharmacokinetics and Pharmacodynamics in Humans. J. Clin. Pharmacol. 2000; 40(3): 219–230. https://doi.org/10.1177/00912700022008883.
33.   Krecic-Shepard, M. E.; Park, K.; Barnas, C.; Slimko, J.; Kerwin, D. R.; Schwartz, J. B. Race and Sex Influence Clearance of Nifedipine: Results of a Population Study. Clin. Pharmacol. Ther. 2000; 68(2): 130–142. https://doi.org/10.1067/MCP.2000.108678.
34.   Rajaram, C. U. Review of Captopril Drug Formulation, Mechanism of Action, Dosage, Use and Adverse Drug Reactions. Res. J. Pharm. Dos. Forms Technol. 2021; 13(2): 157–160. https://doi.org/10.52711/0975-4377.2021.00028.
35.   Baca, E.; Garcia-Garcia, M.; Porras-Chavarino, A. Gender Differences in Treatment Response to Sertraline versus Imipramine in Patients with Nonmelancholic Depressive Disorders. Prog. Neuropsychopharmacol. Biol. Psychiatry. 2004; 28(1):57–65. https://doi.org/10.1016/S0278-5846(03)00177-5.
36.   Kornstein, S. G.; Schatzberg, A. F.; Thase, M. E.; Yonkers, K. A.; McCullough, J. P.; Keitner, G. I.; Gelenberg, A. J.; Davis, S. M.; Harrison, W. M.; Keller, M. B. Gender Differences in Treatment Response to Sertraline versus Imipramine in Chronic Depression. Am. J. Psychiatry. 2000; 157(9): 1445–1452. https://doi.org/10.1176/APPI.AJP.157.9.1445.
37.   Bano, S.; Akhter, S.; Afridi, M. Gender Based Response to Fluoxetine Hydrochloride Medication in Endogenous Depression. J. Coll. Physicians Surg. Pak. 2004.
38.   Yanagisawa, H. Relation between the Chaos Equation and Gender Differences of the Human Brain- Nightingale’s Brain Was the Fixed Type. Asian J. Nurs. Educ. Res. 2017; 7(3): 273–277. https://doi.org/10.5958/2349-2996.2017.00056.8.
39.   Melkersson, K. I.; Hulting, A. L.; Rane, A. J. Dose Requirement and Prolactin Elevation of Antipsychotics in Male and Female Patients with Schizophrenia or Related Psychoses. Br. J. Clin. Pharmacol. 2001; 51(4): 317–324. https://doi.org/10.1046/J.1365-2125.2001.01352.X.
40.   Berkley, K. J. Sex Differences in Pain. Behav. Brain Sci. 1997; 20(3): 371–380. https://doi.org/10.1017/S0140525X97221485.
41.   Pleym, H.; Spigset, O.; Kharasch, E. D.; Dale, O. Gender Differences in Drug Effects: Implications for Anesthesiologists. Acta Anaesthesiol. Scand. 2003; 47(3): 241–259. https://doi.org/10.1034/J.1399-6576.2003.00036.X.
42.   Craft, R. M. Sex Differences in Drug- and Non-Drug-Induced Analgesia. Life Sci. 2003; 72(24): 675–2688. https://doi.org/10.1016/S0024-3205(03)00178-4.
43.   Berger, J. S.; Roncaglioni, M. C.; Avanzini, F.; Pangrazzi, I.; Tognoni, G.; Brown, D. L. Aspirin for the Primary Prevention of Cardiovascular Events in Women and Men: A Sex-Specific Meta-Analysis of Randomized Controlled Trials. JAMA. 2006; 295(3): 306–316. https://doi.org/10.1001/JAMA.295.3.306.
44.   Cavallari, L. H.; Helgason, C. M.; Brace, L. D.; Viana, M. A. G.; Nutescu, E. A. Sex Difference in the Antiplatelet Effect of Aspirin in Patients with Stroke. Ann. Pharmacother. 2006; 40(5): 812–817. https://doi.org/10.1345/APH.1G569.
45.   Valer’evich, B. V.; Vladimirovna, B. A.; Andreevich, L. K.; Isaakovich, V. A.; Vasil’evich, U. V. Distribution and Transmembrane Transport as the Basis of Proper Pharmacodynamics of an Antithrombotic Drug – An Indolinone Derivative. Res. J. Pharm. Technol. 2022; 15(3): 1241–1244. https://doi.org/10.52711/0974-360X.2022.00207.
46.   Krecic-Shepard, M. E.; Barnas, C. R.; Slimko, J.; Schwartz, J. B. Faster Clearance of Sustained Release Verapamil in Men versus Women: Continuing Observations on Sex-Specific Differences after Oral Administration of Verapamil. Clin. Pharmacol. Ther. 2000; 68(3): 286–292. https://doi.org/10.1067/MCP.2000.109356.
47.   Kang, D.; Verotta, D.; Krecic-Shepard, M. E.; Modi, N. B.; Gupta, S. K.; Schwartz, J. B. Population Analyses of Sustained-Release Verapamil in Patients: Effects of Sex, Race, and Smoking. Clin. Pharmacol. Ther. 2003; 73(1): 31–40. https://doi.org/10.1067/MCP.2003.21.
48.   Dadashzadeh, S.; Javadian, B.; Sadeghian, S. The Effect of Gender on the Pharmacokinetics of Verapamil and Norverapamil in Human. Biopharm. Drug Dispos. 2006; 27(7): 329–334. https://doi.org/10.1002/BDD.512.
49.   Manteuffel, M.; Williams, S.; Chen, W.; Verbrugge, R. R.; Pittman, D. G.; Steinkellner, A. Influence of Patient Sex and Gender on Medication Use, Adherence, and Prescribing Alignment with Guidelines. J. Womens. Health (Larchmt). 2014; 23(2): 112–119. https://doi.org/10.1089/JWH.2012.3972.
50.   Kjeldsen, S. E.; Kolloch, R. E.; Leonetti, G.; Mallion, J. M.; Zanchetti, A.; Elmfeldt, D.; Warnold, I.; Hansson, L. Influence of Gender and Age on Preventing Cardiovascular Disease by Antihypertensive Treatment and Acetylsalicylic Acid. The HOT Study. Hypertension Optimal Treatment. J. Hypertens. 2000; 18(5): 629–642. https://doi.org/10.1097/00004872-200018050-00017.
51.   Vree, T. B.; Dammers, E.; Valducci, R. Sex-Related Differences in the Pharmacokinetics of Isosorbide-5-Mononitrate (60 Mg) after Repeated Oral Administration of Two Different Original Prolonged Release Formulations. Int. J. Clin. Pharmacol. Ther. 2004; 42(8): 463–472. https://doi.org/10.5414/CPP42463.
52.   Rademaker, M. Do Women Have More Adverse Drug Reactions? American Journal of Clinical Dermatology. 2001. https://doi.org/10.2165/00128071-200102060-00001.
53.   Rajput, M. D.; Rajput, Y. B.; Rajput, L. D. A Review on Adverse Drug Reaction. Asian J. Pharm. Res. 2020; 10(3): 221–225. https://doi.org/10.5958/2231-5691.2020.00038.6.
54.   Drici, M. D.; Clément, N. Is Gender a Risk Factor for Adverse Drug Reactions? The Example of Drug-Induced Long Qt Syndrome. Drug Saf. 2001; 24(8): 575–585. https://doi.org/10.2165/00002018-200124080-00002/METRICS.
55.   Abubakar, A. R.; Simbak, N. Bin; Haque, M. Adverse Drug Reactions: Predisposing Factors, Modern Classifications and Causality Assessment. Res. J. Pharm. Technol. 2014; 7(9): 1091–1098.
56.   Dutta, M.; Prashad, L. Prevalence and Risk Factors of Polypharmacy among Elderly in India: Evidence from SAGE Data. Int. J. Public Ment. Heal. Neurosci.2015;2.
57.   Menaka, K.; Sarumathy, S.; Sivakumar, T. Study on the Adverse Reactions of Antipsychotics and Therapeutic Drug Monitoring of Olanzapine in Psychiatric Patients. Res. J. Pharm. Technol. 2016; 9(6): 687–690. https://doi.org/10.5958/0974-360X.2016.00128.1.
58.   The Effect of Digoxin on Mortality and Morbidity in Patients with Heart Failure. N. Engl. J. Med. 1997; 336(8): 525–533. https://doi.org/10.1056/NEJM199702203360801.
59.   Rathore, S. S.; Wang, Y.; Krumholz, H. M. Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure. N. Engl. J. Med. 2002; 347(18): 1403–1411. https://doi.org/10.1056/NEJMOA021266.
60.   Regitz-Zagrosek, V. Therapeutic Implications of the Gender-Specific Aspects of Cardiovascular Disease. Nat. Rev. Drug Discov. 2006; 5(5): 425–439. https://doi.org/10.1038/NRD2032.
61.   Goud, C. M.; Ghazanfar, S. M. Nimesulide – A Drug to Be Banned Completely. Asian J. Pharm. Res. 2021; 11(2): 132–137. https://doi.org/10.52711/2231-5691.2021.00025.
62.   Kumar, S.; Badruddeen; Singh, S.; Akhtar, J.; Khan, M.; Ahmad, M.; Ahmad, U. Assessment of Analgesics Induced Adverse Drug Reactions in a Tertiary Care Hospital. Res. J. Pharm. Technol. 2020; 13: 4861–4864. https://doi.org/10.5958/0974-360X.2020.00855.0.

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