Author(s):
Hassan Luqman Adepoju, Anyanwu Godson Emeka, Basiru Afisu, Ifeoluwapo Oyebola Asekun-Olarinmoye, Adamu Shettima Pogu, Agbor Cyril Abang
Email(s):
luqman_hassan@unilesa.edu.ng
DOI:
10.52711/2321-5836.2024.00024 
Address:
Hassan Luqman Adepoju1, Anyanwu Godson Emeka2, Basiru Afisu3, Ifeoluwapo Oyebola Asekun-Olarinmoye4, Adamu Shettima Pogu5, Agbor Cyril Abang5
1Department of Anatomy, Faculty of Basic Medical Science, University of Ilesa, Ilesa, Osun State, Nigeria.
2Department of Anatomy, Faculty of Basic Medical Science, University of Nigeria, Enugu Campus
3Department of Physiology, Faculty of Vetenary Medicine, University of Ilorin, Ilorin, Nigeria.
4Department of Public Health, Faculty of Basic Medical Sciences, University of Ilesa, Ilesa, Osun State.
5Department of Anatomy, Faculty of Basic Medial Sciences, Imo State University, Owerri, Nigeria.
*Corresponding Author
Published In:
Volume - 16,
Issue - 3,
Year - 2024
ABSTRACT:
Aims: Lead as a common environmental toxic metal, causes many histological, physiological and biomedical abnormalities in human and animals. This study evaluated the antioxidant potential of tannins on serum level of testosterone, LH and FSH and histology of the testes of male Wistar rats. Materials and Methods: Twenty-five adult male Wistar rats were divided into five (5) groups, (n=5). Group NS was administered normal saline only, Group PBO was administered with 30mg/kg body weight (BW) of lead, group LDTPB was administered with 50 mg/kg BW of tannins and 30mg/kg BW of lead, group MDTPB was administered with 100mg/kg BW of tannins and 30mg/kg BW of lead, group HDTPB was administered 150mg/kg BW of tannins and 30mg/kg BW of lead orally for 28 days. The animals were sacrificed and testes were harvested on day 29 of the experiment and histological and histochemistry studies done using the H&E and VVG staining respectively. Sperm parameters (motility, concentration), sex hormones (Testosterone, LH, FSH) and antioxidant activities were also determined. Results: There was Leydig cell proliferation and an increase series of spermatogenesis of the testes in the rats of groups administered with lead and tannins different doses (LDTPB, MDTPB and HDTPB) when compared with rats administered with lead only. Rats in groups LDTPB, MDTPB and HDTPB had a significant increase in levels of serum testosterone (p<0.05) when compared with positive control group (2). There was increase in levels of FSH in MDTPB and HDTPB groups when compared with positive control (2). Increased MDA levels were observed in the rats given lead only, PBO when compared to NS group. The rats given lead and tannins significant growth of seminiferous epithelium, improved sperm quality, and had decreased MDA levels. Conclusion: This study demonstrated the protective role of tannins fraction of Cyperus esculentus on lead-induced testicular toxicity in male Wistar rats.
Cite this article:
Hassan Luqman Adepoju, Anyanwu Godson Emeka, Basiru Afisu, Ifeoluwapo Oyebola Asekun-Olarinmoye, Adamu Shettima Pogu, Agbor Cyril Abang. Tannin-Rich Fraction of Cyperus esculentus Protects against Lead-Induced Testicular Toxicity in Male Wistar Rats through ITS Antioxidant Properpty. Research Journal of Pharmacology and Pharmacodynamics.2024;16(3):137-2. doi: 10.52711/2321-5836.2024.00024
Cite(Electronic):
Hassan Luqman Adepoju, Anyanwu Godson Emeka, Basiru Afisu, Ifeoluwapo Oyebola Asekun-Olarinmoye, Adamu Shettima Pogu, Agbor Cyril Abang. Tannin-Rich Fraction of Cyperus esculentus Protects against Lead-Induced Testicular Toxicity in Male Wistar Rats through ITS Antioxidant Properpty. Research Journal of Pharmacology and Pharmacodynamics.2024;16(3):137-2. doi: 10.52711/2321-5836.2024.00024 Available on: https://rjppd.org/AbstractView.aspx?PID=2024-16-3-1
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