The Schiff base 1,3-bis(2-hydroxybenzylidene)thiourea was prepared from salicylaldehyde and thiourea by condensation method using standard procedure. Analgesic and antipyretic activities 1,3-bis(2-hydroxybenzylidene)thiourea Schiff base were studied using albino rats of both the sexes. Animals were divided into three groups, each consisting of four animals. Group 1 served as control and group 2 received standard drug. Group 3 received 250 mg/kg of 1,3-bis(2-hydroxybenzylidene)thiourea . For the determination of antipyretic activity, pyrexia was induced by 20% yeast suspension. The analgesic activity was determined by tail immersion method. The results obtained showed that the Schiff base was found to exhibit analgesic, antipyretic activities. The analgesic activity of the Schiff base compared to the standard drug pentazocine was found to be higher in the first hour and then the activity decreases slowly. The reduction in the rectal temperature for this compound was observed to be less than the standard drug paracetamol. PASS prediction of 1,3-bis(2-hydroxybenzylidene)thiourea schiff base was found to exhibit Laccase inhibitor and Monophenol monooxygenase inhibitor activities greater than 90% and can also possessed other activities like Corticosteroid side-chain-isomerase inhibitor, 3-Hydroxybenzoate 4-monooxygenase inhibitor greater than 80%
Cite this article:
Valli G, Ramu K, Mareeswari P. Analgesic, Antipyretic and pass prediction activities of 1,3-bis (2-hydroxybenzylidene) thiourea. Research J. Pharmacology and Pharmacodynamics. 2012; 4(3): 172-175.