Author(s): Yogita Singh, Arun Kumar Jaiswal

Email(s): arunjais@rediffmail.com

DOI: 10.5958/2321-5836.2016.00019.7   

Address: Yogita Singh1, 2, Arun Kumar Jaiswal1,3*
1Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, India
2Department of Zoology, Udai Pratap College, Varanasi, Uttar Pradesh, India
3Department of Psychology, Mahatma Gandhi Kashi Vidyapith, Varanasi 221002, Uttar Pradesh, India
*Corresponding Author

Published In:   Volume - 8,      Issue - 3,     Year - 2016


ABSTRACT:
Behavioural teratological effects of prenatal fluoxetine exposure were investigated on behavioural despair and learned helplessness parameters of depression in rats. Pregnant rats were administered fluoxetine (5 and 10 mg/kg/day) orally once a day during the gestation days 13 to 20. The pups born were subjected to forced swimming test of behavioural despair and learned helplessness test at 8 weeks of age. The results indicated that prenatal fluoxetine treatment (5 and 10 mg/kg/day) induced significant increase in time of immobility in forced swimming test and number of escape failures in learned helplessness test in rat offspring. Rat offspring treated with 5 and 10 mg /kg fluoxetine during the prenatal period displayed dose dependent significant increase in time of immobility in behavioural despair test and number of escape failures in learned helplessness test in comparison to control rat offspring. The findings highlight that prenatal fluoxetine treatment caused depressive like behavioural alterations in the rat offspring.


Cite this article:
Yogita Singh, Arun Kumar Jaiswal. Effects of maternal fluoxetine treatment on behavioural despair and learned helplessness parameters of depression in the rat progeny. Res. J. Pharmacology & Pharmacodynamics.2016; 8(3): 106-110. doi: 10.5958/2321-5836.2016.00019.7


Recomonded Articles:

Author(s): Purnendu Panda, Banamali Das, DS Sahu, SK Meher, GC Bhuyna, BK Das, MM Rao.

DOI: 10.5958/2321-5836.2016.00008.2         Access: Open Access Read More

Author(s): Shameer Pasha, Mohamed Khaleel, Sukhen Som.

DOI: Not Available         Access: Open Access Read More

Author(s): Aswani P. S., Kshirod Kumar Ratha, Dighe Dattatray Pandurang, M. M. Rao, Remya Vijayan

DOI: 10.5958/2321-5836.2018.00008.3         Access: Open Access Read More

Author(s): Kishan K G, Shekshavali. T, Kuppast I.J, Kishan Kumar MA, Jeevanagouda Patil

DOI: 10.5958/2321-5836.2016.00030.6         Access: Open Access Read More

Author(s): Sudhanshu Kumar Meher, Banmali Das, Purnendu Panda, GC Bhuyan, MM Rao.

DOI: 10.5958/2321-5836.2016.00006.9         Access: Open Access Read More

Author(s): Manasa K.S, Kuppast I.J, Kishan Kumar M.A , Akshara K

DOI: 10.5958/2321-5836.2016.00034.3         Access: Open Access Read More

Author(s): Lubna Azmi, Shyam Sundar Gupta, Ila Shukla, Padam Kant, O. P. Sidhu, Ch. V. Rao

DOI: 10.5958/2321-5836.2017.00001.5         Access: Open Access Read More

Author(s): Dipti Phadtare, Rajashri Kulkarni

DOI: 10.5958/2321-5836.2016.00016.1         Access: Open Access Read More

Author(s): Sudhanshu Kumar Meher, P K Mukherjee, S K Banarjee Chaudhury, Bani Marjit, B PShaw.

DOI: 10.5958/2321-5836.2016.00014.8         Access: Open Access Read More

Author(s): Nadiminti Satish Reddy, Vidyasabbani, B. Pravanthi, B. Vijaya Laxmi, B. Harika.

DOI: 10.5958/2321-5836.2016.00023.9         Access: Open Access Read More

Author(s): U. S. Jijith , C. R. Sudhakaran Nair, K. Pramod

DOI: 10.5958/2321-5836.2016.00001.X         Access: Open Access Read More

Author(s): Indranil Chanda, Smriti Rekha Chanda , Sadhan Kr Dutta.

DOI: Not Available         Access: Open Access Read More

Author(s): Shilpa Maria, IJ Kuppast, JH Virupaksha, M Vanajakshi, K Prasad.

DOI: 10.5958/2321-5836.2015.00033.6         Access: Open Access Read More

Author(s): Rohan R. Vakhariya, Rutuja R. Shaha, Archana R. Dhole, C.S Magdum

DOI: 10.5958/2321-5836.2017.00013.1         Access: Open Access Read More

Research Journal of Pharmacology and Pharmacodynamics (RJPPD) is an international, peer-reviewed journal....... Read more >>>

RNI: Not Available                     
DOI: 10.5958 2321-5836 


Recent Articles




Tags