Pharmacological Evaluation of Lactuca canadensis. Linn extract on Anti-Inflammatory activity in Experimental Animals

Yashashri P. Dhokane; Umair Akhtar

doi:10.52711/2321-5836.2024.00003

Research Journal of Pharmacology and Pharmacodynamics

ISSN

2321-5836 (Online)
0975-4407 (Print)

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Pharmacological Evaluation of Lactuca canadensis. Linn extract on Anti-Inflammatory activity in Experimental Animals

Author(s): Yashashri P. Dhokane, Umair Akhtar

Email(s): yashree61604@gmail.com

DOI: 10.52711/2321-5836.2024.00003

Address: Yashashri P. Dhokane*, Umair Akhtar
Department of Pharmacology, Vidyabharati College of Pharmacy, C.K. Naidu Road, Camp, Amravati – 444602 (Maharashtra) India.
*Corresponding Author

Published In: Volume - 16, Issue - 1, Year - 2024

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ABSTRACT:
Background: The body's defence mechanism against hazardous stimuli is inflammation. This procedure not only eliminates the harmful stimuli but also aids in starting the tissue's wound-healing process. Studying the effects of Lactuca canadensis linn. leaves extract in a croton oil-induced inflammatory model is the goal of the current investigation in an effort to discover a novel herbal remedy for the treatment of inflammation. Methods: Alkaloids, Terpenes, flavonoids, and carbohydrates were found in the Lactuca canadensis Linn leaves extract, according to the phytochemical screening Diclofenac sodium injection (1ml/kg) is a common medication. Croton oil was injected into the left hind paw's subplantar surface in a quantity of 0.1ml. Using a vernier calliper, the volumes of the injected paws were measured before and 0, 1, 2, 3, and 5hours after the croton oil challenge. Result: The herbal aqueous leaves extract of Lactuca canadensis Linn. showed promising efficacy by lowering the paw volume in comparison to the control group as a result of its anti-inflammatory action for Croton oil caused Rat paw edoema. At doses of 200 and 400 mg/kg, the aqueous extract significantly (P 0.05) reduced paw oedema by 33.11% and 44.4% on hour five. Conclusion: The findings of this investigation show that the leaves' aqueous extract has significant (P 0.05) anti-inflammatory potential.

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Cite this article:
Yashashri P. Dhokane, Umair Akhtar. Pharmacological Evaluation of Lactuca canadensis. Linn extract on Anti-Inflammatory activity in Experimental Animals. Research Journal of Pharmacology and Pharmacodynamics. 2024;16(1):15-8. doi: 10.52711/2321-5836.2024.00003

Cite(Electronic):
Yashashri P. Dhokane, Umair Akhtar. Pharmacological Evaluation of Lactuca canadensis. Linn extract on Anti-Inflammatory activity in Experimental Animals. Research Journal of Pharmacology and Pharmacodynamics. 2024;16(1):15-8. doi: 10.52711/2321-5836.2024.00003 Available on: https://rjppd.org/AbstractView.aspx?PID=2024-16-1-3

REFERENCES:
1.   A review on medicinal plants as a source of antiinflammatory agents Zuli Shingala, Bhavik Chauhan and Jankhana Baraiya
2.   Sandoval M, Okuhama NN, Zhang X-J, Condezo LA, Lao J, Angeles FM, et al. Anti-inflammation and antioxidant activities of cat’s claw (Uncaria tomentos and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. 2002; 9: 325–37.
3.   Sandoval M, Okuhama NN, Zhang X-J, Condezo LA, Lao J, Angeles FM, et al. Anti-inflammation and antioxidant activities of cat’s claw (Uncaria tomentos and Uncaria guianensis) are independent of their alkaloid content. Phytomedicine. 2002; 9: 325–37.
4.   Huerta C, Castellsague J, Varas-Lorenzo C and García Rodríguez LA. Nonsteroidal Anti-Inflammatory Drugs and Risk of ARF in the General Population. Am J Kidney Dis. 2002, 45(3): 531-539
5.   Wallace J.L. PathogenesisofNSAIDinducedgastroduodenalmucosalinjury. Best Practice Res Clinical Gastroenterology. 2001, 15: 691-703
6.   Nunes CD, Barreto Arantes M, Menezes de Faria Pereira S, Leandro da Cruz L, de Souza Passos M, Pereira de Moraes L, Vieira IJ, Barros de Oliveira D. Plants as sources of anti-inflammatory agents. Molecules. 2020 Aug 15; 25(16): 3726.
7.   Sofowora, A., Ogunbodede, E., and Onayade, A. (2013). The Role and Place of Medicinal Plants in the Strategies for Disease Prevention. Afr. J. Tradit Complement. Altern. Med. 10 (5), 210–229. doi:10.4314/ajtcam.v10i5.2
8.   Issa, A. Y., Volate, S. R., and Wargovich, M. J. (2006). The Role of Phytochemicals in Inhibition of Cancer and Inflammation: New Directions and Perspectives. J. Food Compost. Anal. 19 (5), 405–419. doi:10.1016/j.jfca.2006.02.009
9.   World Health Organization (2013). WHO Traditional Medicine Strategy: 2014- 2023. Geneva: World Health Organization.
10.   Birhanu, Z. (2013). Traditional Use of Medicinal Plants by the Ethnic Groups of Gondar Zuria District, north-western Ethiopia. J. Nat. Remedies 8. doi:10. 18311/jnr/2013/117
11.   Sofowora, A., Ogunbodede, E., and Onayade, A. (2013). The Role and Place of Medicinal Plants in the Strategies for Disease Prevention. Afr. J. Tradit Complement. Altern. Med. 10 (5), 210–229. doi:10.4314/ajtcam.v10i5.2
12.   Ugboko, H. U., Nwinyi, O. C., Oranusi, S. U., Fatoki, T. H., and Omonhinmin, C. A. (2020). Antimicrobial Importance of Medicinal Plants in Nigeria. ScientificWorldJournal 2020, 7059323. doi:10.1155/2020/7059323
13.   Harvey, A. (2000). Strategies for Discovering Drugs from Previously Unexplored Natural Products. Drug Discov. Today 5 (7), 294–300. doi:10.1016/S1359- 6446(00)01511-7
14.   Khan MSA, Ahmad I. Herbal medicine: current trends and future prospects: New Look to Phytomedicine Elsevier; 2019. p. p3–13.
15.   Awuchi CG. Medicinal plants: The medical, food, and nutritional biochemistry and uses. IJAAR. 2019
16.   Mensah ML, Komlaga G, Forkuo AD, Firempong C, Anning AK, Dickson RA. Toxicity and safety implications of herbal medicines used in Africa. Herb Med. 2019;63:849–1992.
17.   Brima EI. Toxic elements in diferent medicinal plants and the impact on human health. Int J Environ Res Public Health. 2017;14:1209.
18.   David A, Chinedu E. The importance of toxicity testing. JPBS. 2013;4:146–8.
19.   Riley, M.; Balick, M.J.; Cox, P.A. Plants, People, and Culture: The science of ethnobotany. Bull. Torrey Bot. Club 1996, 123, 366–367.
20.   FAO. Commission on Genetic Resources for Food and Agriculture Assessments. The State of the World’s Biodiversity for Food and Agriculture; Bélanger, J., Pilling, D., Eds.; FAO: Rome, Italy, 2019.
21.   Shahidi, F.; Ambigaipalan, P. Phenolics and polyphenolics in foods, beverages and spices: Antioxidant activity and health effects—A review. J. Funct. Foods 2015, 18, 820–897.
22.   Kinupp, V.F.; Lorenzi, H. Plantas Alimentícias Não Convencionais (PANC) no Brasil: Guia de Identificação, Aspectos Nutricionais e Receitas Ilustradas; Instituto Plantarum de Estudos da Flora: São Paulo, Brasil, 2019.
23.   Souza, M.R.M.; Correa, E.J.A.; Guimarães, G.; Gomes, P.R. O Potencial do Ora-pro-nobis na diversificação da produção agrícola familiar. Rev. Bras. Agroecol. 2009, 4, 3550–3554.
24.   Kim, M.J.; Moon, Y.; Tou, J.C.; Mou, B.; Waterland, N.L. Nutritional value, bioactive compounds and health benefits of lettuce (Lactuca sativa L.). J. Food Compos. Anal. 2016, 49, 19–34.
25.   Monge, M.; Kilian, N.; Anderberg, A.; Semir, J. Two new records of Lactuca L. (Cichorieae, Asteraceae) in South America. Rev. Bras. Biosci. 2016, 14, 117–1
26.   Venkateshwarlu Goli, Kanakam Vijay Bhaskar, Sravan Prasad Macharla, Jimmidi.Bhaskar, P. Suvarna Devi, T. Ramchander. Effects of Anti-Inflammatory Activity of Mimosa pudica. Asian J. Pharm. Res. 1(3): July-Sept. 2011; Page 69-71.
27.   Ghanshyam Dhalendra, Trilochan Satapathy, Amit Roy. Animal Models for Inflammation: A Review. Asian J. Pharm. Res. 3(4): Oct. - Dec.2013; Page 207-212.
28.   Muhammed Shakkeel K.V, Anjan Kumar, Veeresh Babu. D, Narayana Swamy V.B. Pharmacological Evaluation of Trichilia connaroides Bark for Analgesic and Anti-inflammatory activity in Experimental Animal Models. Asian J. Pharm. Res. 5(3): July- Sept., 2015; Page 138-144.
29.   Prajakta P Shinde, Shahu D Khule, Sneha Sonawane, Suvarna Shelke. Analgesic activity and anti-inflammatory activity of methanolic extract of plant Sida cordata in carrageenan-induced paw edema in rats. Asian Journal of Pharmaceutical Research. 2021; 11(3):143-6.
30.   P. Lalitha, V. Sachithanandam, N. S. Swarnakumar, R. Sridhar. Review on Anti-inflammatory Properties of Mangrove plants. Asian J. Pharm. Res. 2019; 9(4):273-288.
31.   Brijesh Kumar Saroj, Shreyash Tripathi, Mohd Yaqub Khan. To Study Anti-Inflammatory and Analgesic Activity of Desmostachia bipinnata (l.) Stapf on Experimental Animals. Asian J. Pharm. Tech. 2018; 8 (4):211-226.