Author(s): Yashashri P. Dhokane, Umair Akhtar

Email(s): yashree61604@gmail.com

DOI: 10.52711/2321-5836.2024.00003   

Address: Yashashri P. Dhokane*, Umair Akhtar
Department of Pharmacology, Vidyabharati College of Pharmacy, C.K. Naidu Road, Camp, Amravati – 444602 (Maharashtra) India.
*Corresponding Author

Published In:   Volume - 16,      Issue - 1,     Year - 2024


ABSTRACT:
Background: The body's defence mechanism against hazardous stimuli is inflammation. This procedure not only eliminates the harmful stimuli but also aids in starting the tissue's wound-healing process. Studying the effects of Lactuca canadensis linn. leaves extract in a croton oil-induced inflammatory model is the goal of the current investigation in an effort to discover a novel herbal remedy for the treatment of inflammation. Methods: Alkaloids, Terpenes, flavonoids, and carbohydrates were found in the Lactuca canadensis Linn leaves extract, according to the phytochemical screening Diclofenac sodium injection (1ml/kg) is a common medication. Croton oil was injected into the left hind paw's subplantar surface in a quantity of 0.1ml. Using a vernier calliper, the volumes of the injected paws were measured before and 0, 1, 2, 3, and 5hours after the croton oil challenge. Result: The herbal aqueous leaves extract of Lactuca canadensis Linn. showed promising efficacy by lowering the paw volume in comparison to the control group as a result of its anti-inflammatory action for Croton oil caused Rat paw edoema. At doses of 200 and 400 mg/kg, the aqueous extract significantly (P 0.05) reduced paw oedema by 33.11% and 44.4% on hour five. Conclusion: The findings of this investigation show that the leaves' aqueous extract has significant (P 0.05) anti-inflammatory potential.


Cite this article:
Yashashri P. Dhokane, Umair Akhtar. Pharmacological Evaluation of Lactuca canadensis. Linn extract on Anti-Inflammatory activity in Experimental Animals. Research Journal of Pharmacology and Pharmacodynamics. 2024;16(1):15-8. doi: 10.52711/2321-5836.2024.00003

Cite(Electronic):
Yashashri P. Dhokane, Umair Akhtar. Pharmacological Evaluation of Lactuca canadensis. Linn extract on Anti-Inflammatory activity in Experimental Animals. Research Journal of Pharmacology and Pharmacodynamics. 2024;16(1):15-8. doi: 10.52711/2321-5836.2024.00003   Available on: https://rjppd.org/AbstractView.aspx?PID=2024-16-1-3


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