Volume No. :   12

Issue No. :  2

Year :  2020

ISSN Print :  0975-4407

ISSN Online :  2321-5836


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Pharmacological Evaluation of Livodac Tablet on Ethanol Induced Hepatotoxicity Models in Wistar Rats



Address:   Pradnya. N. Jagtap, Prachali Ramdas Chavan, Dr. Suhas shitole
Pune District Education Association’s, Seth Govind Raghunath Sable College of Pharmacy, Saswad 412301, Tal. Purandar, Dist. Pune, Maharashtra, India.
*Corresponding Author
DOI No: 10.5958/2321-5836.2020.00018.X

ABSTRACT:
The various pharmaceutical dosages are affected on human health after long time or repeated use. Ethanol induce the toxicity to liver to use in high dose. These study was describe the significant effect of livodac formulation on Ethanol induced liver cirrhosis in rats. The thirty six animal were grouped in six set (1) Normal controle, it kept at normal condition (2) Disease controle group contains 50% Ethanol (2ml/kg) (3) Standard group Silyamarin gives with 50% Ethanol (2ml/kg) (4) Test drug (100mg/kg) with 50% Ethanol (2ml/kg) (5) Test drug (200mg/kg) with 50% Ethanol (2ml/kg) (6) Test drug (400mg/kg) with 50% Ethanol (2ml/kg). The present study show result of three dosage of livodac formulation should be significantly reduce the level of SGOT, SGPT, Total bilirubin, Total protein, Alkaline phosphate in the induce hepatotoxic model. The given livodac formulation effectively used as hepatoprotective agent in the management of liver cirrhosis caused by to various used drugs.
KEYWORDS:
Pharmaceutical dosages, Ethanol, Hepatoprotective, Liver cirrhosis, livodac.
Cite:
Pradnya. N. Jagtap, Prachali Ramdas Chavan, Suhas shitole. Pharmacological Evaluation of Livodac Tablet on Ethanol Induced Hepatotoxicity Models in Wistar Rats. Res. J. Pharmacology and Pharmacodynamics.2020; 12(2): 91-96.
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