Author(s):
R. Santhoshkumar, K. R Sathyaramanan, N. Venkateswaramurthy
Email(s):
venkateswaramurthy.n@jkkn.ac.in
DOI:
10.52711/2321-5836.2023.00030 
Address:
R. Santhoshkumar1, K. R Sathyaramanan2, N. Venkateswaramurthy3*
1Pharm D Intern, JKKN College of Pharmacy, Erode, Tamilnadu.
2Pharm D Intern, JKKN College of Pharmacy, Erode, Tamilnadu.
3Professor and Head, Department of Pharmacy Practice, JKKN College of Pharmacy, Erode, Tamilnadu.
*Corresponding Author
Published In:
Volume - 15,
Issue - 4,
Year - 2023
ABSTRACT:
This review article focuses on the post-COVID symptoms and Multisystem Inflammatory Syndrome in Children (MIS-C) observed in India. The study sheds light on the various clinical characteristics and outcomes associated with these conditions by examining available literature and data. The findings highlight the diverse range of symptoms experienced by children, including fever, gastrointestinal and respiratory manifestations, and skin rash. Additionally, rare observations such as HSP-like rash, gangrene, and arthritis were noted. The severity of MIS-C is evident, with a significant proportion of children experiencing shock and requiring mechanical ventilation. However, the review also emphasizes the favorable outcomes observed among children without preexisting comorbidities, indicating the potential for recovery in these cases. The review also provides reassuring findings regarding coronary outcomes during follow-up. This review underscores the urgent need for ongoing research, surveillance, and effective management strategies to address the long-term implications of post-COVID symptoms and MIS-C in Indian children. The insights presented in this article contribute to a better understanding of the impact of MIS-C and inform future strategies to mitigate its effects on the health and well-being of affected children in India.
Cite this article:
R. Santhoshkumar, K. R Sathyaramanan, N. Venkateswaramurthy. Post-COVID Symptoms and Multisystem Inflammatory Syndrome in Children (MIS-C) in India: A Review. Research Journal of Pharmacology and Pharmacodynamics.2023;15(4):165-1. doi: 10.52711/2321-5836.2023.00030
Cite(Electronic):
R. Santhoshkumar, K. R Sathyaramanan, N. Venkateswaramurthy. Post-COVID Symptoms and Multisystem Inflammatory Syndrome in Children (MIS-C) in India: A Review. Research Journal of Pharmacology and Pharmacodynamics.2023;15(4):165-1. doi: 10.52711/2321-5836.2023.00030 Available on: https://rjppd.org/AbstractView.aspx?PID=2023-15-4-4
REFERENCES:
1. United Nations. Policy Brief: The Impact of COVID-19 on Children. Published April 15, 2020. Accessed January 28, 2022. https://unsdg.un.org/resources/policy-brief-impact-covid-19-children.
2. Centers for Disease Control and Prevention. COVID-19 and Children. Updated November 23, 2021. Accessed January 28, 2022. https://www.cdc.gov/coronavirus/2019-ncov/science/science-briefs/covid-19-and-children.html.
3. World Health Organization. COVID-19 and the Need for Action on Mental Health. Published May 13, 2020. Accessed January 28, 2022. https://www.who.int/teams/mental-health-and-substance-use/covid-19.
4. United Nations Educational, Scientific and Cultural Organization. COVID-19 Impact on Education. Accessed January 28, 2022. https://en.unesco.org/covid19/educationresponse.
5. United Nations Educational, Scientific and Cultural Organization. School closures caused by Coronavirus (COVID-19). Accessed January 28, 2022. https://en.unesco.org/covid19/educationresponse/globalmonitoring.
6. United Nations Children’s Fund. COVID-19: One year on - From bad to worse for children. Published March 11, 2021. Accessed January 28, 2022. https://www.unicef.org/reports/covid-19-one-year-bad-worse-children.
7. Loades ME, Chatburn E, Higson-Sweeney N, et al. Rapid systematic review: The impact of social isolation and loneliness on the mental health of children and adolescents in the context of COVID-19. J Am Acad Child Adolesc Psychiatry. 2020;59(11):1218-1239.e3. doi:10.1016/j.jaac.2020.05.009.
8. Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: rapid review of the evidence. Lancet. 2020;395(10227):912-920. doi:10.1016/S0140-6736(20)30460-8.
9. Lee J. Mental health effects of school closures during COVID-19. Lancet Child Adolesc Health. 2020;4(6):421. doi:10.1016/S2352-4642(20)30109-7.
10. World Health Organization. Maintaining essential health services: operational guidance for the COVID-19 context. Published June 1, 2020. Accessed January 28, 2022. https://www.who.int/publications-detail-redirect/WHO-2019-nCoV-essential-health-services-2020.1.
11. United Nations Children’s Fund. Immunization in the context of COVID-19 pandemic. Updated April 15, 2021. Accessed January 28, 2022. https://www.unicef.org/coronavirus/immunization-context-covid-19-pandemic.
12. National Institute for Health and Care Excellence. COVID-19 rapid guideline: managing the long-term effects of COVID-19. Published December 18, 2020. Accessed January 28, 2022. https://www.nice.org.uk/guidance/ng188.
13. Davis HE et al; Characterizing long COVID in an international cohort: 7 months of symptoms and their impact. medRxiv. Preprint posted online April 24, 2021. doi:10.1101/2021.04.22.21255864.
14. Nabavi N. Long COVID: how to define it and how to manage it. Lancet Psychiatry. 2021;8(8):645-647. doi:10.1016/S2215-0366(21)00203-4.
15. Buonsenso D, Munblit D, De Rose C, Sinatti D. Preliminary evidence on long COVID in children. Acta Paediatr. 2021;110(7):2208-2211. doi:10.1111/apa.15770.
16. Swann OV, Holden KA, Turtle L, et al. Long COVID in Children: A Systematic Review and Meta-analysis. medRxiv. doi:10.1101/2021.05.10.21256790.
17. Centers for Disease Control and Prevention. Multisystem Inflammatory Syndrome in Children (MIS-C) Associated with Coronavirus Disease 2019 (COVID-19). https://www.cdc.gov/mis-c/hcp/. Published 2021. Accessed May 31, 2023.
18. Whittaker E, Bamford A, Kenny J, et al. Clinical Characteristics of 58 Children with a Pediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2. JAMA. 2020;324(3):259-269. doi:10.1001/jama.2020.10369.
19. Royal College of Paediatrics and Child Health. Guidance: Paediatric Multisystem Inflammatory Syndrome Temporally Associated with COVID-19. https://www.rcpch.ac.uk/resources/guidance-paediatric-multisystem-inflammatory-syndrome-temporally-associated-covid-19. Published 2021. Accessed May 31, 2023.
20. Feldstein LR, Rose EB, Horwitz SM, et al. Multisystem Inflammatory Syndrome in U.S. Children and Adolescents. N Engl J Med. 2020;383(4):334-346. doi:10.1056/NEJMoa2021680.
21. Lee PY, Day-Lewis M, Henderson LA, et al. Distinct Clinical and Immunological Features of SARS-CoV-2-Induced Multisystem Inflammatory Syndrome in Children. J Clin Invest. 2020;130(11):5942-5950. doi:10.1172/JCI141113.
22. American Academy of Pediatrics. Multisystem Inflammatory Syndrome in Children (MIS-C) Interim Guidance. https://services.aap.org/en/pages/2019-novel-coronavirus-covid-19-infections/clinical-guidance/multisystem-inflammatory-syndrome-in-children-mis-c-interim-guidance/. Published 2021. Accessed May 31, 2023.
23. Singh U, Arora S, Jindal AK, Goyal K, Chugh K. Clinical Profile and Follow-up of Children with COVID-19 Infection: A Tertiary Care Centre Experience. Indian J Pediatr. 2021;88(9):948-954.
24. Jain S, Sen S, Lakshmivenkateshiah S, et al. Multisystem inflammatory syndrome in children with COVID-19 in Mumbai, India. Indian Pediatr. 2020;57:1015-1019.
25. Dhanalakshmi K, Venkataraman A, Balasubramanian S, et al. Epidemiological and clinical profile of pediatric inflammatory multisystem syndrome - temporally associated withSARS-CoV-2 (PIMS-TS) in Indian children. Indian Pediatr.2020;57:1010-1014.
26. Shobhavat L, Solomon R, Rao S, et al. Multisysteminflammatory syndrome in children: clinical features andmanagement-intensive care experience from a pediatricpublic hospital in Western India. Indian J Crit Care Med.2020;24:1089-1094. doi:10.5005/jp-journals-10071-23650.
27. Balagurunathan M, Natarajan T, Karthikeyan J,et al. Clinical spectrum and short-term outcomes of multisystem inflammatory syndrome in children in a south Indianhospital. Clin Exp Pediatr. 2021;64:531-537. doi:10.3345/cep.2020.01584.
28. Gupta DS, Chopra N, Singh A. Clinical manifestations and outcome of multisystem inflammatory syndrome in children (MIS-C) in a tertiary care hospital of North India. J Trop Pediatr. 2021;67:1-9. doi:10.1093/tropej/fmab012.
29. Sachdeva M, Agarwal A, Sra HK, et al. Multisystem Inflammatory Syndrome Associated With COVID-19 in Children (MIS-C): A Systematic Review of Studies From India. Indian Pediatr. 2022;59:563-569. doi:10.1007/s13312-022-02454-0.
30. Angurana SK, Awasthi P, Thakur A, et al. Intensive care needs and short-term outcome of multisystem inflammatory syndrome in children (MIS-C): Experience from NorthIndia. J Trop Pediatr. 2021;67:fmab055. doi:10.1093/tropej/fmab055.
31. Nayak S, Panda PC, Biswal B, et al. Eastern India collaboration on multisystem inflammatory syndrome in children (EICOMISC): A multicenter observational study of 134 cases. Front Pediatr. 2022;10:834039. doi:10.3389/fped.2022.834039
32. Tiwari A, Balan S, Rauf A, et al. COVID-19 related multisystem inflammatory syndrome in children (MIS-C): a hospital-based prospective cohort study from Kerala, India. BMJ Paediatr Open. 2021;5(1):e001195. doi:10.1136/bmjpo-2021-001195.
33. Awasthi P, Kumar V, Naganur S, et al. Multisystem inflammatory syndrome in children: Follow-up of a cohort from North India. Am J Trop Med Hyg. 2022;106(4):1108-1112. doi:10.4269/ajtmh.21-0890
34. Bagri NK, Deepak RK, Meena S, et al. Outcomes of multisystem inflammatory syndrome in children temporally related to COVID-19: a longitudinal study. Rheumatol Int. 2022;42(3):477-484. doi:10.1007/s00296-021-04961-w.