ABSTRACT:
Alzheimer's disease is the most frequent cause of dementia worldwide and its incidence is increasing due to the world's aging population. Alzheimer's disease (AD) is one of the greatest medical care challenges of our century and is the main cause of dementia and neurodegenerative diseases. Dementia is defined as an acquired loss of cognition in many cognitive domains. Herbal medicine has evolved as the greatest option for the treatment of Alzheimer's disease due to its wide availability, low cost, high patient compliance, ease of formulation and lack of harmful side effects. Novel techniques can be used for the development of herbal medicine. In these research article animal studies, has been carried out to known Alzheimer disease (AD) caused by chemical compounds may be helpful in deeper understanding the mechanism of disease and AD treatment. In the present study, the efficacy of an Methanolic Extract of Epiphyllum oxypetalum Leaves (MEEO) was evaluated against scopolamine- induced Alzheimer's in the Swiss albino mice. As Epiphyllum oxypetalum Leaves contain many active chemical constituents, including phenolic compounds, flavonoids, Terpenoids, Tannins, and alkaloids, etc., serve as useful antioxidants present in this plant. The Epiphyllum oxypetalum Leaves were reported to have antioxidant properties. The antioxidant potential is the best supplement for the diseases associated with oxidative stress. Hence, an attempt was made to evaluate the anti-Alzheimer activity from Epiphyllum oxypetalum Leaves extract.
Cite this article:
Dyuthi HY, U. Rajashekhar. Neuroprotective Activity of Epiphyllum oxypetallum Leaves Extract on Scopolamine Induced Alzhemier’s Disease Model. Research Journal of Pharmacology and Pharmacodynamics. 2025; 17(1):1-7. doi: 10.52711/2321-5836.2025.00001
Cite(Electronic):
Dyuthi HY, U. Rajashekhar. Neuroprotective Activity of Epiphyllum oxypetallum Leaves Extract on Scopolamine Induced Alzhemier’s Disease Model. Research Journal of Pharmacology and Pharmacodynamics. 2025; 17(1):1-7. doi: 10.52711/2321-5836.2025.00001 Available on: https://rjppd.org/AbstractView.aspx?PID=2025-17-1-1
REFERENCE:
1. R Howes MJ, J Houghton P. Ethnobotanical treatment strategies against Alzheimer's disease. Current Alzheimer Research. 2012; 9(1): 67-85.
2. Anns Morrrison, Constantine Lyketsos. A Review on the pathophysiology of Alzheimers disease and directions in treatment. Advanced Studies in Nursing, 3, 2005, 5.
3. Bischkopf J, Busse A, Angermeyer MC. Mild Cognitive impairment a review on prevalence, incidence, prevalence & mortality and outcome according to current approaches. Blackwell Munks. 2002; 106: 403-14.
4. Thanvi B., Robinson T. Sporadic cerebral amyloid angiopathy— an important cause of cerebral haemorrhage in older people. Age Ageing. 2006; 35: 565–571. 10.1093/ageing/afl108
5. Wang X., Michaelis M. L., Michaelis E. K. Functional genomics of brain aging and Alzheimers disease: focus on selective neuronal vulnerability. Curr. Genomics. 2010; 54.2174/138920210793360943.
6. NIH National Institute on Aging (NIA). NIA scientists and other experts review this content to ensure it is accurate and up to date. Content reviewed: May 16, 2017.
7. Bienias JL, Beckett LA, Bennett DA, Wilson RS, Evans DA. Design of the Chicago Health and Aging Project (CHAP). J Alzheimers Dis. 2003; 5: 349–355
8. Dandekar R, Fegade B and Bhaskar VH: GC-MS analysis of phytoconstituents in alcohol extract of Epiphyllum oxypetalum leaves, Journal of Pharmacognosy and Phytochemistry 2015; 148-54.
9. Mahmad A, Shaharun MS, Saad B and Dash GK: Epiphyllum oxypetalum Haw.: a lesser known medicinal plant. Indo American Journal of pharmaceutical Sciences 2017;
10. Narisawa T and Fukaura Y: N‐methylnitrosourea‐induced colon tumorigenesis by ursodeoxycholic acid in F344 rats. Japanese Journal of Cancer Research. 1998; 1009-13
11. Hanish Singh Jayasingh, C., Mohamed Mansor, M., Afiq, A., Yasothini, M., Punitha, C., and Pavithiraa, C. (2020). Neurocognitive effects of Prunus domestica fruit extract on scopolamine-induced amnesic mice. Journal of Applied Pharmaceutical Science. https://doi.org/10.7324/japs.2020.10118.
12. Khooshbu P, Ansari I. Evaluation of anti-Alzheimer activity of alcoholic extract of Costus pictus d. Don Leaves in Wistar albino rats. Asian J Pharm Clin Res. 2019; 13(2):36–43.
13. Shaikh RK. Kanase Evaluation of anti-alzheimer’s activity of alcoholic extract of hylocereus undatus fruits in wistar albino rats. ILPSR. 2022; 13(9): 1567-80.
14. Raviteja, S., Manandhar, S., Priya, K., Hari, G., & Ranganath Pai, K. S. (2021). Protective role of caffeic acid in cognitive dysfunction and oxidative stress induced by colchicine in rats. Indian Journal of Pharmaceutical Education, 55(2s), s457–s467. https://doi.org/10.5530/ijper.55.2s.117
15. Ellman GL, Courtney KD, Andres V Jr, Feather-Stone RM. A new and rapid colorimetric determination of acetylcholinesterase activity. Biochem Pharmacol [Internet]. 1961; 7(2): 88–95. Available from: http://dx.doi.org/10.1016/0006-2952(61)90145-9
16. Ştefǎnuţ MN, Cǎta A, Pop R, Moşoarcǎ C, Zamfir AD. Anthocyanins HPLC-DAD and MS Characterization, Total Phenolics, and Antioxidant Activity of Some Berries Extracts. Anal Lett. 2011; 44(18).
17. Marklund S, Marklund G. Involvement of the superoxide anion radical in the autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur J Biochem [Internet]. 1974; 47(3): 469–74. Available from: http://dx.doi.org/10.1111/j.1432-1033.1974.tb03714